New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 24, 2009, Pages 8186-8196

  Rodríguez, Jorge ^a,b   Arán, Vicente J ^d   Boiani, Lucía ^c   Olea Azar, Claudio ^a   Lavaggi, María Laura ^c   González, Mercedes ^c   Cerecetto, Hugo ^c   Maya, Juan Diego ^a   Carrasco Pozo, Catalina ^a   Cosoy, Hernán Speisky ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN   (Chile)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^d INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

5 Nitroindazole; Mode of action; Trypanosoma cruzi

Indexed keywords

1 (2 DIETHYLAMINOETHYL) 3 METHOXY 5 NITRO 1H INDAZOLE; 1 (2 DIISOPROPYLAMINOETHYL) 3 METHOXY 5 NITRO 1H INDAZOL HYDROCHLORIDE; 1 (2 DIMETHYLAMINOETHYL) 3 METHOXY 5 NITRO 1H INDAZOLE; 1 (3 DIMETHYLAMINOPROPYL) 3 METHOXY 5 NITRO 1H INDAZOLE; 1 (5 AZEPANYLPENTYL) 3 BENZYLOXY 5 NITRO 1H INDAZOLE; 3 BENZYLOXY 1 (2 DIETHYLAMINOETHYL) 5 NITRO 1H INDAZOL HYDROCHLORIDE; 3 BENZYLOXY 1 (2 DIISOPROPYLAMINOETHYL) 5 NITRO 1H INDAZOL HYDROCHLORIDE; 3 BENZYLOXY 1 (2 DIMETHYLAMINOETHYL) 5 NITRO 1H INDAZOLE; 3 BENZYLOXY 1 (2 MORPHOLINOETHYL) 5 NITRO 1H INDAZOL HYDROCHLORIDE; 3 BENZYLOXY 1 (6 DIMETHYLAMINOHEXYL) 5 NITRO 1H INDAZOLE; 3 BENZYLOXY 5 NITRO 1 (2 PIPERIDINOETHYL) 1H INDAZOL HYDROCHLORIDE; 3 BENZYLOXY 5 NITRO 1 (5 PYRROLIDINOPENTYL) 1H INDAZOLE; 3 BENZYLOXY 5 NITRO 1 (6 PIPERIDINOHEXYL) 1H INDAZOLE; 3 BENZYLOXY 5 NITRO 1 [5 (1,2,3,4 TETRAHYDROISOQUINOL 2 YL)PENTYL] 1H INDAZOL HYDROCHLORIDE; 3 METHOXY 1 (2 MORPHOLINOETHYL) 5 NITRO 1H INDAZOLE; 3 METHOXY 5 NITRO 1 (2 PIPERIDINOETHYL) 1H INDAZOLE; 3 METHOXY 5 NITRO 1 (3 PIPERIDINOPROPYL) 1H INDAZOLE; ANTIPROTOZOAL AGENT; INDAZOLE DERIVATIVE; NIFURTIMOX; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIC POTENTIOMETRY; CYTOSOLIC FRACTION; CYTOTOXICITY; DIMERIZATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMISTRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MACROPHAGE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REDUCTION; TRYPANOSOMA CRUZI;

CHAGAS DISEASE; CRYSTALLOGRAPHY, X-RAY; DNA, PROTOZOAN; HELA CELLS; HUMANS; INDAZOLES; NITROIMIDAZOLES; OXIDATION-REDUCTION; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 71849091591     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.030     Document Type: Article

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