메뉴 건너뛰기




Volumn 120, Issue 20, 2012, Pages 4134-4142

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; AUTOANTIBODY; AUTOANTIGEN; BETA2 GLYCOPROTEIN 1; PENICILLIN G; QUINIDINE; QUININE; THROMBOCYTE FACTOR 4; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

EID: 84869818090     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-06-389445     Document Type: Review
Times cited : (7)

References (101)
  • 1
    • 34547789273 scopus 로고    scopus 로고
    • Drug-induced immune thrombocytopenia
    • DOI 10.1056/NEJMra066469
    • Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med. 2007;357(6):580-587. (Pubitemid 47236283)
    • (2007) New England Journal of Medicine , vol.357 , Issue.6 , pp. 580-587
    • Aster, R.H.1    Bougie, D.W.2
  • 2
    • 83455210452 scopus 로고    scopus 로고
    • A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis
    • Cuker A, Coles AJ, Sullivan H, et al. A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis. Blood. 2011;118(24):6299-6305.
    • (2011) Blood , vol.118 , Issue.24 , pp. 6299-6305
    • Cuker, A.1    Coles, A.J.2    Sullivan, H.3
  • 3
    • 77949654482 scopus 로고    scopus 로고
    • Thrombocytopenic purpura after measles-mumps-rubella vaccination: A systematic review of the literature and guidance for management
    • Mantadakis E, Farmaki E, Buchanan GR. Thrombocytopenic purpura after measles-mumps-rubella vaccination: a systematic review of the literature and guidance for management. J Pediatr. 2010;156(4):623-628.
    • (2010) J Pediatr , vol.156 , Issue.4 , pp. 623-628
    • Mantadakis, E.1    Farmaki, E.2    Buchanan, G.R.3
  • 4
    • 69249240344 scopus 로고    scopus 로고
    • The ITP syndrome: Pathogenic and clinical diversity
    • Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009;113(26):6511-6521.
    • (2009) Blood , vol.113 , Issue.26 , pp. 6511-6521
    • Cines, D.B.1    Bussel, J.B.2    Liebman, H.A.3    Luning Prak, E.T.4
  • 5
    • 37049009764 scopus 로고    scopus 로고
    • ITP: Time to bug off?
    • Cines DB. ITP: time to bug off? Blood. 2007;110:3818-3819.
    • (2007) Blood , vol.110 , pp. 3818-3819
    • Cines, D.B.1
  • 6
    • 60549085053 scopus 로고    scopus 로고
    • Pathobiology of secondary immune thrombocytopenia
    • Cines DB, Liebman H, Stasi R. Pathobiology of secondary immune thrombocytopenia. Semin Hematol. 2009;46(1 Suppl 2):S2-S14.
    • (2009) Semin Hematol , vol.46 , Issue.1 SUPPL. 2
    • Cines, D.B.1    Liebman, H.2    Stasi, R.3
  • 7
    • 77951926334 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia
    • Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77-90.
    • (2010) Annu Rev Med , vol.61 , pp. 77-90
    • Arepally, G.M.1    Ortel, T.L.2
  • 8
    • 84858057979 scopus 로고    scopus 로고
    • How i treat heparin-induced thrombocytopenia
    • Cuker A, Cines DB. How I treat heparin-induced thrombocytopenia. Blood. 2012;119(10):2209-2218.
    • (2012) Blood , vol.119 , Issue.10 , pp. 2209-2218
    • Cuker, A.1    Cines, D.B.2
  • 10
    • 77956483253 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Towards standardization of platelet factor 4/heparin antigen tests
    • Greinacher A, Ittermann T, Bagemuhl J, et al. Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests. J Thromb Haemost. 2010;8(9):2025-2031.
    • (2010) J Thromb Haemost , vol.8 , Issue.9 , pp. 2025-2031
    • Greinacher, A.1    Ittermann, T.2    Bagemuhl, J.3
  • 11
    • 67949124723 scopus 로고    scopus 로고
    • Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia
    • Bakchoul T, Giptner A, Najaoui A, Bein G, Santoso S, Sachs UJ. Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2009;7(8):1260-1265.
    • (2009) J Thromb Haemost , vol.7 , Issue.8 , pp. 1260-1265
    • Bakchoul, T.1    Giptner, A.2    Najaoui, A.3    Bein, G.4    Santoso, S.5    Sachs, U.J.6
  • 12
    • 33644745161 scopus 로고    scopus 로고
    • Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: Diagnostic and therapeutic implications
    • DOI 10.1182/blood-2005-08-3122
    • Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood. 2006;107:2346-2353. (Pubitemid 43345554)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2346-2353
    • Rauova, L.1    Zhai, L.2    Kowalska, M.A.3    Arepally, G.M.4    Cines, D.B.5    Poncz, M.6
  • 13
    • 84864562115 scopus 로고    scopus 로고
    • Dynamic antibody binding properties in the pathogenesis of HIT
    • Sachais BS, Litvinov RI, Yarovoi SV, et al. Dynamic antibody binding properties in the pathogenesis of HIT. Blood. 2012;120(5):1137-1142.
    • (2012) Blood , vol.120 , Issue.5 , pp. 1137-1142
    • Sachais, B.S.1    Litvinov, R.I.2    Yarovoi, S.V.3
  • 14
    • 78649742009 scopus 로고    scopus 로고
    • Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia
    • Rauova L, Hirsch JD, Greene TK, et al. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood. 2010;116(23):5021-5031.
    • (2010) Blood , vol.116 , Issue.23 , pp. 5021-5031
    • Rauova, L.1    Hirsch, J.D.2    Greene, T.K.3
  • 15
    • 0019192750 scopus 로고
    • The multiple complexes formed by the interaction of platelet factor 4 with heparin
    • Bock PE, Luscombe M, Marshall SE, Pepper DS, Holbrook JJ. The multiple complexes formed by the interaction of platelet factor 4 with heparin. Biochem J. 1980;191:769-776. (Pubitemid 11223634)
    • (1980) Biochemical Journal , vol.191 , Issue.3 , pp. 769-776
    • Bock, P.E.1    Luscombe, M.2    Marshall, S.E.3
  • 16
    • 0029086769 scopus 로고
    • Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunologic type of heparin-associated thrombocytopenia
    • Greinacher A, Alban S, Dummel V, Franz G, Mueller-Eckhardt C. Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunologic type of heparin-associated thrombocytopenia. Thromb Haemost. 1995;74:886-892.
    • (1995) Thromb Haemost , vol.74 , pp. 886-892
    • Greinacher, A.1    Alban, S.2    Dummel, V.3    Franz, G.4    Mueller-Eckhardt, C.5
  • 20
    • 0023710994 scopus 로고
    • Heparin-induced thrombocytopenia: Laboratory studies
    • Kelton JG, Sheridan D, Santos A, et al. Heparin-induced thrombocytopenia: laboratory studies. Blood. 1988;72(3):925-930.
    • (1988) Blood , vol.72 , Issue.3 , pp. 925-930
    • Kelton, J.G.1    Sheridan, D.2    Santos, A.3
  • 21
    • 84861793285 scopus 로고    scopus 로고
    • PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcgammaRI
    • Kasthuri RS, Glover SL, Jonas W, et al. PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcgammaRI. Blood. 2012;119(22):5285-5293.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5285-5293
    • Kasthuri, R.S.1    Glover, S.L.2    Jonas, W.3
  • 22
    • 80052667085 scopus 로고    scopus 로고
    • Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: New insights into the prothrombotic nature of HIT
    • Kowalska MA, Krishnaswamy S, Rauova L, et al. Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood. 2011;118(10):2882- 2888.
    • (2011) Blood , vol.118 , Issue.10 , pp. 2882-2888
    • Kowalska, M.A.1    Krishnaswamy, S.2    Rauova, L.3
  • 23
    • 0023109003 scopus 로고
    • Immune endothelial-cell injury in heparin-associated thrombocytopenia
    • Cines DB, Tomaski A, Tannenbaum S. Immune endothelial cell injury in heparin-associated thrombocytopenia. N Engl J Med. 1987;316:581-589. (Pubitemid 17024480)
    • (1987) New England Journal of Medicine , vol.316 , Issue.10 , pp. 581-589
    • Cines, D.B.1    Tomaski, A.2    Tannenbaum, S.3
  • 24
    • 84856600313 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: In vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies
    • Krauel K, Hackbarth C, Furll B, Greinacher A. Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies. Blood. 2012;119(5):1248-1255.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1248-1255
    • Krauel, K.1    Hackbarth, C.2    Furll, B.3    Greinacher, A.4
  • 25
    • 84859317732 scopus 로고    scopus 로고
    • Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH)
    • Joglekar MV, Quintana Diez PM, Marcus S, et al. Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH). Thromb Haemost. 2012;107(4):717-725.
    • (2012) Thromb Haemost , vol.107 , Issue.4 , pp. 717-725
    • Joglekar, M.V.1    Quintana Diez, P.M.2    Marcus, S.3
  • 26
    • 84862734540 scopus 로고    scopus 로고
    • Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia
    • Sachais BS, Rux AH, Cines DB, et al. Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia. Blood. 2012;119(25):5955-5962.
    • (2012) Blood , vol.119 , Issue.25 , pp. 5955-5962
    • Sachais, B.S.1    Rux, A.H.2    Cines, D.B.3
  • 27
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306.
    • (2006) J Thromb Haemost , vol.4 , Issue.2 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3
  • 28
    • 70349234331 scopus 로고    scopus 로고
    • How i treat the antiphospholipid syndrome
    • Giannakopoulos B, Krilis SA. How I treat the antiphospholipid syndrome. Blood. 2009;114(10):2020-2030.
    • (2009) Blood , vol.114 , Issue.10 , pp. 2020-2030
    • Giannakopoulos, B.1    Krilis, S.A.2
  • 29
    • 70350149398 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: A comprehensive review of a complex and multisystemic disease
    • Palomo I, Segovia F, Ortega C, Pierangeli S. Antiphospholipid syndrome: a comprehensive review of a complex and multisystemic disease. Clin Exp Rheumatol. 2009;27(4):668-677.
    • (2009) Clin Exp Rheumatol , vol.27 , Issue.4 , pp. 668-677
    • Palomo, I.1    Segovia, F.2    Ortega, C.3    Pierangeli, S.4
  • 30
    • 33846243719 scopus 로고    scopus 로고
    • Current concepts on the pathogenesis of the antiphospholipid syndrome
    • DOI 10.1182/blood-2006-04-001206
    • Giannakopoulos B, Passam F, Rahgozar S, Krilis SA. Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood. 2007;109(2):422-430. (Pubitemid 46105935)
    • (2007) Blood , vol.109 , Issue.2 , pp. 422-430
    • Giannakopoulos, B.1    Passam, F.2    Rahgozar, S.3    Krilis, S.A.4
  • 31
    • 84864150391 scopus 로고    scopus 로고
    • The significance of autoantibodies against beta2-glycoprotein i
    • de Groot PG, Urbanus RT. The significance of autoantibodies against beta2-glycoprotein I. Blood. 2012;120(2):266-274.
    • (2012) Blood , vol.120 , Issue.2 , pp. 266-274
    • De Groot, P.G.1    Urbanus, R.T.2
  • 33
    • 39549099464 scopus 로고    scopus 로고
    • Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome
    • DOI 10.1016/j.blre.2007.09.001, PII S0268960X07000525
    • Urbanus RT, Derksen RH, de Groot PG. Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome. Blood Rev. 2008;22(2):93-105. (Pubitemid 351282442)
    • (2008) Blood Reviews , vol.22 , Issue.2 , pp. 93-105
    • Urbanus, R.T.1    Derksen, R.H.M.W.2    De Groot, P.G.3
  • 34
    • 70449390005 scopus 로고    scopus 로고
    • The association between circulating antibodies against domain i of beta2-glycoprotein i and thrombosis: An international multicenter study
    • de Laat B, Pengo V, Pabinger I, et al. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost. 2009;7(11):1767-1773.
    • (2009) J Thromb Haemost , vol.7 , Issue.11 , pp. 1767-1773
    • De Laat, B.1    Pengo, V.2    Pabinger, I.3
  • 35
    • 78650963444 scopus 로고    scopus 로고
    • An international multicentre-laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti-beta2-glycoprotein autoantibodies
    • De Laat B, Derksen RH, Reber G, et al. An international multicentre-laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti-beta2-glycoprotein autoantibodies. J Thromb Haemost. 2011;9(1):149-153.
    • (2011) J Thromb Haemost , vol.9 , Issue.1 , pp. 149-153
    • De Laat, B.1    Derksen, R.H.2    Reber, G.3
  • 40
    • 0033570889 scopus 로고    scopus 로고
    • Crystal structure of human beta2-glycoprotein I: Implications for phospholipid binding and the antiphospholipid syndrome
    • DOI 10.1093/emboj/18.22.6228
    • Schwarzenbacher R, Zeth K, Diederichs K, et al. Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome. EMBO J. 1999;18(22):6228-6239. (Pubitemid 29533227)
    • (1999) EMBO Journal , vol.18 , Issue.22 , pp. 6228-6239
    • Schwarzenbacher, R.1    Zeth, K.2    Diederichs, K.3    Gries, A.4    Kostner, G.M.5    Laggner, P.6    Prassl, R.7
  • 42
    • 0033830410 scopus 로고    scopus 로고
    • Epitope studies with anti-beta 2-glycoprotein i antibodies from autoantibody and immunized sources
    • Reddel SW, Wang YX, Sheng YH, Krilis SA. Epitope studies with anti-beta 2-glycoprotein I antibodies from autoantibody and immunized sources. J Autoimmun. 2000;15(2):91-96.
    • (2000) J Autoimmun , vol.15 , Issue.2 , pp. 91-96
    • Reddel, S.W.1    Wang, Y.X.2    Sheng, Y.H.3    Krilis, S.A.4
  • 44
    • 33846236309 scopus 로고    scopus 로고
    • 2-glycoprotein I: Mutation studies including residues R39 to R43
    • DOI 10.1002/art.22306
    • Ioannou Y, Pericleous C, Giles I, Latchman DS, Isenberg DA, Rahman A. Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum. 2007;56(1):280-290. (Pubitemid 46106202)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.1 , pp. 280-290
    • Ioannou, Y.1    Pericleous, C.2    Giles, I.3    Latchman, D.S.4    Isenberg, D.A.5    Rahman, A.6
  • 45
    • 65349188214 scopus 로고    scopus 로고
    • In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain i of beta2-glycoprotein i: Proof of concept
    • Ioannou Y, Romay-Penabad Z, Pericleous C, et al. In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept. J Thromb Haemost. 2009;7(5):833-842.
    • (2009) J Thromb Haemost , vol.7 , Issue.5 , pp. 833-842
    • Ioannou, Y.1    Romay-Penabad, Z.2    Pericleous, C.3
  • 47
    • 0028983571 scopus 로고
    • "Anticardiolipin" autoantibodies recognize beta 2-glycoprotein i in the absence of phospholipid: Importance of Ag density and bivalent binding
    • Roubey RA, Eisenberg RA, Harper MF, Winfield JB. " Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. J Immunol. 1995;154(2):954-960.
    • (1995) J Immunol , vol.154 , Issue.2 , pp. 954-960
    • Roubey, R.A.1    Eisenberg, R.A.2    Harper, M.F.3    Winfield, J.B.4
  • 48
    • 77956488547 scopus 로고    scopus 로고
    • Beta2-glycoprotein i can exist in 2 conformations: Implications for our understanding of the antiphospholipid syndrome
    • Agar C, van Os GM, Morgelin M, et al. Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. Blood. 2010;116(8):1336-1343.
    • (2010) Blood , vol.116 , Issue.8 , pp. 1336-1343
    • Agar, C.1    Van Os, G.M.2    Morgelin, M.3
  • 49
    • 82755189081 scopus 로고    scopus 로고
    • Induction of anti-beta2 -glycoprotein i autoantibodies in mice by protein H of Streptococcus pyogenes
    • van Os GM, Meijers JC, Agar C, et al. Induction of anti-beta2 -glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes. J Thromb Haemost. 2011;9(12):2447-2456.
    • (2011) J Thromb Haemost , vol.9 , Issue.12 , pp. 2447-2456
    • Van Os, G.M.1    Meijers, J.C.2    Agar, C.3
  • 50
    • 84864387345 scopus 로고    scopus 로고
    • Val247Leu beta2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: Systematic review and meta-analysis
    • Chamorro AJ, Marcos M, Miron-Canelo JA, Cervera R, Espinosa G. Val247Leu beta2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: systematic review and meta-analysis. Autoimmun Rev. 2012;11(10):705-712.
    • (2012) Autoimmun Rev , vol.11 , Issue.10 , pp. 705-712
    • Chamorro, A.J.1    Marcos, M.2    Miron-Canelo, J.A.3    Cervera, R.4    Espinosa, G.5
  • 51
    • 33344456904 scopus 로고    scopus 로고
    • 2-glycoprotein I only after a conformational change
    • DOI 10.1182/blood-2005-05-1943
    • de Laat B, Derksen RH, van Lummel M, Pennings MT, de Groot PG. Pathogenic anti-β2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change. Blood. 2006;107(5):1916-1924. (Pubitemid 43289372)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1916-1924
    • De Laat, B.1    Derksen, R.H.W.M.2    Van Lummel, M.3    Pennings, M.T.T.4    De Groot, P.G.5
  • 52
    • 0030931521 scopus 로고    scopus 로고
    • The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins)
    • Horkko S, Miller E, Branch DW, Palinski W, Witztum JL. The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins). Proc Natl Acad Sci U S A. 1997;94(19):10356-10361.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.19 , pp. 10356-10361
    • Horkko, S.1    Miller, E.2    Branch, D.W.3    Palinski, W.4    Witztum, J.L.5
  • 53
    • 79960646137 scopus 로고    scopus 로고
    • Molecular pathophysiology of the antiphospholipid syndrome: The role of oxidative post-translational modification of beta 2 glycoprotein i
    • Passam FH, Giannakopoulos B, Mirarabshahi P, Krilis SA. Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I. J Thromb Haemost. 2011;9(Suppl 1):275-282.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 1 , pp. 275-282
    • Passam, F.H.1    Giannakopoulos, B.2    Mirarabshahi, P.3    Krilis, S.A.4
  • 54
    • 80052341165 scopus 로고    scopus 로고
    • Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen beta2-glycoprotein i
    • Ioannou Y, Zhang JY, Qi M, et al. Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen beta2-glycoprotein I. Arthritis Rheum. 2011;63(9):2774-2782.
    • (2011) Arthritis Rheum , vol.63 , Issue.9 , pp. 2774-2782
    • Ioannou, Y.1    Zhang, J.Y.2    Qi, M.3
  • 55
    • 77956898617 scopus 로고    scopus 로고
    • Beta2 glycoprotein i is a substrate of thiol oxidoreductases
    • Passam FH, Rahgozar S, Qi M, et al. Beta2 glycoprotein I is a substrate of thiol oxidoreductases. Blood. 2010;116(11):1995-1997.
    • (2010) Blood , vol.116 , Issue.11 , pp. 1995-1997
    • Passam, F.H.1    Rahgozar, S.2    Qi, M.3
  • 56
    • 77956903176 scopus 로고    scopus 로고
    • Naturally occurring free thiols within beta 2-glycoprotein i in vivo: Nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury
    • Ioannou Y, Zhang JY, Passam FH, et al. Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury. Blood. 2010;116(11):1961-1970.
    • (2010) Blood , vol.116 , Issue.11 , pp. 1961-1970
    • Ioannou, Y.1    Zhang, J.Y.2    Passam, F.H.3
  • 58
    • 84862496402 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in antiphospholipid syndrome: Implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment
    • Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment. Blood. 2012;119(24):5859- 5870.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5859-5870
    • Perez-Sanchez, C.1    Ruiz-Limon, P.2    Aguirre, M.A.3
  • 60
    • 78650665944 scopus 로고    scopus 로고
    • Domain v peptides inhibit beta2-glycoprotein I-mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation
    • Fleming SD, Pope MR, Hoffman SM, et al. Domain V peptides inhibit beta2-glycoprotein I-mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation. J Immunol. 2010;185(10):6168-6178.
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 6168-6178
    • Fleming, S.D.1    Pope, M.R.2    Hoffman, S.M.3
  • 61
    • 77950435764 scopus 로고    scopus 로고
    • Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: Evidence for a novel effect for an old antimalarial drug
    • Rand JH, Wu XX, Quinn AS, et al. Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood. 2010;115(11):2292-2299.
    • (2010) Blood , vol.115 , Issue.11 , pp. 2292-2299
    • Rand, J.H.1    Wu, X.X.2    Quinn, A.S.3
  • 62
    • 0141445991 scopus 로고    scopus 로고
    • 2-Glycoprotein I Increase Platelet Deposition to Collagen via Interaction with Phospholipids and the Apolipoprotein E Receptor 2′
    • DOI 10.1074/jbc.M212655200
    • Lutters BC, Derksen RH, Tekelenburg WL, Lenting PJ, Arnout J, de Groot PG. Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem. 2003;278(36):33831-33838. (Pubitemid 37553217)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 33831-33838
    • Lutters, B.C.H.1    Derksen, R.H.W.M.2    Tekelenburg, W.L.3    Lenting, P.J.4    Arnout, J.5    De Groot, P.G.6
  • 63
    • 77449133188 scopus 로고    scopus 로고
    • Beta2 glycoprotein i (beta2GPI) binds platelet factor 4 (PF4): Implications for the pathogenesis of antiphospholipid syndrome
    • Sikara MP, Routsias JG, Samiotaki M, Panayotou G, Moutsopoulos HM, Vlachoyiannopoulos PG. Beta2 glycoprotein I (beta2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome. Blood. 2010;115(3):713-723.
    • (2010) Blood , vol.115 , Issue.3 , pp. 713-723
    • Sikara, M.P.1    Routsias, J.G.2    Samiotaki, M.3    Panayotou, G.4    Moutsopoulos, H.M.5    Vlachoyiannopoulos, P.G.6
  • 64
    • 78649720936 scopus 로고    scopus 로고
    • Is there an association between complement activation and antiphospholipid antibody-related thrombosis?
    • Devreese KM, Hoylaerts MF. Is there an association between complement activation and antiphospholipid antibody-related thrombosis? Thromb Haemost. 2010;104(6):1279-1281.
    • (2010) Thromb Haemost , vol.104 , Issue.6 , pp. 1279-1281
    • Devreese, K.M.1    Hoylaerts, M.F.2
  • 65
    • 84864485595 scopus 로고    scopus 로고
    • Induction of durable remission in recurrent catastrophic antiphospholipid syndrome via inhibition of terminal complement with eculizumab
    • Shapira I, Andrade D, Allen SL, Salmon JE. Induction of durable remission in recurrent catastrophic antiphospholipid syndrome via inhibition of terminal complement with eculizumab. Arthritis Rheum. 2012;64(8):2719-2723.
    • (2012) Arthritis Rheum , vol.64 , Issue.8 , pp. 2719-2723
    • Shapira, I.1    Andrade, D.2    Allen, S.L.3    Salmon, J.E.4
  • 66
    • 0025999820 scopus 로고
    • Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Clinical experience in 108 patients
    • Bell WR, Braine HG, Ness PM, Kickler TS. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: clinical experience in 108 patients. N Engl J Med. 1991;325(6):398-403.
    • (1991) N Engl J Med , vol.325 , Issue.6 , pp. 398-403
    • Bell, W.R.1    Braine, H.G.2    Ness, P.M.3    Kickler, T.S.4
  • 68
    • 0032569840 scopus 로고    scopus 로고
    • Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura
    • DOI 10.1056/NEJM199811263392203
    • Tsai HM, Lian EC. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 1998;339(22):1585- 1594. (Pubitemid 28536133)
    • (1998) New England Journal of Medicine , vol.339 , Issue.22 , pp. 1585-1594
    • Tsai, H.-M.1    Lian, E.C.-Y.2
  • 69
    • 77956824177 scopus 로고    scopus 로고
    • Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
    • Zheng XL, Wu HM, Shang D, et al. Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Haematologica. 2010;95(9):1555-1562.
    • (2010) Haematologica , vol.95 , Issue.9 , pp. 1555-1562
    • Zheng, X.L.1    Wu, H.M.2    Shang, D.3
  • 70
    • 3042839778 scopus 로고    scopus 로고
    • Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand-factor multimers under flow
    • DOI 10.1182/blood-2004-01-0107
    • Bernardo A, Ball C, Nolasco L, Moake JF, Dong JF. Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow. Blood. 2004;104(1):100-106. (Pubitemid 38879844)
    • (2004) Blood , vol.104 , Issue.1 , pp. 100-106
    • Bernardo, A.1    Ball, C.2    Nolasco, L.3    Moake, J.F.4    Dong, J.-F.5
  • 73
    • 70350015029 scopus 로고    scopus 로고
    • Von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size
    • Jin SY, Skipwith CG, Shang D, Zheng XL. von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size. J Thromb Haemost. 2009;7(10):1749-1752.
    • (2009) J Thromb Haemost , vol.7 , Issue.10 , pp. 1749-1752
    • Jin, S.Y.1    Skipwith, C.G.2    Shang, D.3    Zheng, X.L.4
  • 74
    • 0242266981 scopus 로고    scopus 로고
    • Shear stress and von Willebrand factor in health and disease
    • Tsai HM. Shear stress and von Willebrand factor in health and disease. Semin Thromb Hemost. 2003;29(5):479-488.
    • (2003) Semin Thromb Hemost , vol.29 , Issue.5 , pp. 479-488
    • Tsai, H.M.1
  • 76
    • 77956514337 scopus 로고    scopus 로고
    • Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress
    • Skipwith CG, Cao W, Zheng XL. Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J Biol Chem. 2010;285(37):28596-28603.
    • (2010) J Biol Chem , vol.285 , Issue.37 , pp. 28596-28603
    • Skipwith, C.G.1    Cao, W.2    Zheng, X.L.3
  • 77
    • 77449105475 scopus 로고    scopus 로고
    • Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13
    • Chen J, Fu X, Wang Y, et al. Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. Blood. 2010;115(3):706-712.
    • (2010) Blood , vol.115 , Issue.3 , pp. 706-712
    • Chen, J.1    Fu, X.2    Wang, Y.3
  • 78
    • 45549101029 scopus 로고    scopus 로고
    • Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells
    • DOI 10.1111/j.1538-7836.2008.02989.x
    • Cao WJ, Niiya M, Zheng XW, Shang DZ, Zheng XL. Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. J Thromb Haemost. 2008;6(7):1233-1235. (Pubitemid 351859136)
    • (2008) Journal of Thrombosis and Haemostasis , vol.6 , Issue.7 , pp. 1233-1235
    • Cao, W.J.1    Niiya, M.2    Zheng, X.W.3    Shang, D.Z.4    Zheng, X.L.5
  • 79
    • 79551536840 scopus 로고    scopus 로고
    • N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice
    • Chen J, Reheman A, Gushiken FC, et al. N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. J Clin Invest. 2011;121(2):593-603.
    • (2011) J Clin Invest , vol.121 , Issue.2 , pp. 593-603
    • Chen, J.1    Reheman, A.2    Gushiken, F.C.3
  • 80
    • 68649114583 scopus 로고    scopus 로고
    • The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand factor mediated ex vivo platelet function in acute myocardial infarction
    • Spiel AO, Mayr FB, Ladani N, et al. The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand factor mediated ex vivo platelet function in acute myocardial infarction. Platelets. 2009;20(5):334-340.
    • (2009) Platelets , vol.20 , Issue.5 , pp. 334-340
    • Spiel, A.O.1    Mayr, F.B.2    Ladani, N.3
  • 81
    • 77951679429 scopus 로고    scopus 로고
    • The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo
    • Mayr FB, Knobl P, Jilma B, et al. The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo. Transfusion. 2010;50(5):1079-1087.
    • (2010) Transfusion , vol.50 , Issue.5 , pp. 1079-1087
    • Mayr, F.B.1    Knobl, P.2    Jilma, B.3
  • 82
    • 79960058122 scopus 로고    scopus 로고
    • Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs
    • Ulrichts H, Silence K, Schoolmeester A, et al. Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs. Blood. 2011;118(3):757-765.
    • (2011) Blood , vol.118 , Issue.3 , pp. 757-765
    • Ulrichts, H.1    Silence, K.2    Schoolmeester, A.3
  • 83
    • 79960071636 scopus 로고    scopus 로고
    • The in vitro effect of the new antithrombotic drug candidate ALX-0081 on blood samples of patients undergoing percutaneous coronary intervention
    • van Loon JE, de Jaegere PP, Ulrichts H, et al. The in vitro effect of the new antithrombotic drug candidate ALX-0081 on blood samples of patients undergoing percutaneous coronary intervention. Thromb Haemost. 2011;106(1):165-171.
    • (2011) Thromb Haemost , vol.106 , Issue.1 , pp. 165-171
    • Van Loon, J.E.1    De Jaegere, P.P.2    Ulrichts, H.3
  • 84
    • 84860490555 scopus 로고    scopus 로고
    • The TITAN trial: Assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura
    • Holz JB. The TITAN trial: assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura. Transfus Apher Sci. 2012;46(3):343-346.
    • (2012) Transfus Apher Sci , vol.46 , Issue.3 , pp. 343-346
    • Holz, J.B.1
  • 85
    • 80052350022 scopus 로고    scopus 로고
    • A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura
    • Jilma-Stohlawetz P, Gilbert JC, Gorczyca ME, Knobl P, Jilma B. A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura. Thromb Haemost. 2011;106(3):539-547.
    • (2011) Thromb Haemost , vol.106 , Issue.3 , pp. 539-547
    • Jilma-Stohlawetz, P.1    Gilbert, J.C.2    Gorczyca, M.E.3    Knobl, P.4    Jilma, B.5
  • 86
    • 84860316787 scopus 로고    scopus 로고
    • Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
    • Jian C, Xiao J, Gong L, et al. Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. Blood. 2012;119(16):3836-3843.
    • (2012) Blood , vol.119 , Issue.16 , pp. 3836-3843
    • Jian, C.1    Xiao, J.2    Gong, L.3
  • 87
    • 80052964635 scopus 로고    scopus 로고
    • Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain
    • Pos W, Sorvillo N, Fijnheer R, et al. Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain. Haematologica. 2011;96(11):1670-1677.
    • (2011) Haematologica , vol.96 , Issue.11 , pp. 1670-1677
    • Pos, W.1    Sorvillo, N.2    Fijnheer, R.3
  • 88
    • 77950414918 scopus 로고    scopus 로고
    • Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor
    • Jin SY, Skipwith CG, Zheng XL. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor. Blood. 2010;115(11):2300-2310.
    • (2010) Blood , vol.115 , Issue.11 , pp. 2300-2310
    • Jin, S.Y.1    Skipwith, C.G.2    Zheng, X.L.3
  • 89
    • 77949882442 scopus 로고    scopus 로고
    • An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF
    • Pos W, Crawley JT, Fijnheer R, Voorberg J, Lane DA, Luken BM. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood. 2010;115(8):1640-1649.
    • (2010) Blood , vol.115 , Issue.8 , pp. 1640-1649
    • Pos, W.1    Crawley, J.T.2    Fijnheer, R.3    Voorberg, J.4    Lane, D.A.5    Luken, B.M.6
  • 90
    • 80052968358 scopus 로고    scopus 로고
    • Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis
    • Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, Zheng XL. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol. 2011;31(10):2261-2269.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.10 , pp. 2261-2269
    • Xiao, J.1    Jin, S.Y.2    Xue, J.3    Sorvillo, N.4    Voorberg, J.5    Zheng, X.L.6
  • 91
    • 55249121695 scopus 로고    scopus 로고
    • Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells
    • Peipp M, Lammerts van Bueren JJ, Schneider-Merck T, et al. Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells. Blood. 2008;112(6):2390-2399.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2390-2399
    • Peipp, M.1    Lammerts Van Bueren, J.J.2    Schneider-Merck, T.3
  • 92
    • 33745725970 scopus 로고    scopus 로고
    • Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: A systematic literature review
    • Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2006;65(7):845-851.
    • (2006) Ann Rheum Dis , vol.65 , Issue.7 , pp. 845-851
    • Avouac, J.1    Gossec, L.2    Dougados, M.3
  • 93
    • 77956245423 scopus 로고    scopus 로고
    • PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
    • Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, Wang Y. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med. 2010;207(9):1853-1862.
    • (2010) J Exp Med , vol.207 , Issue.9 , pp. 1853-1862
    • Li, P.1    Li, M.2    Lindberg, M.R.3    Kennett, M.J.4    Xiong, N.5    Wang, Y.6
  • 94
    • 84861227655 scopus 로고    scopus 로고
    • Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps
    • Dwivedi N, Upadhyay J, Neeli I, et al. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum. 2012;64(4):982-992.
    • (2012) Arthritis Rheum , vol.64 , Issue.4 , pp. 982-992
    • Dwivedi, N.1    Upadhyay, J.2    Neeli, I.3
  • 96
    • 0031883095 scopus 로고    scopus 로고
    • Antibody responses to DNA in normal immunity and aberrant immunity
    • Pisetsky DS. Antibody responses to DNA in normal immunity and aberrant immunity. Clin Diagn Lab Immunol. 1998;5(1):1-6. (Pubitemid 28062936)
    • (1998) Clinical and Diagnostic Laboratory Immunology , vol.5 , Issue.1 , pp. 1-6
    • Pisetsky, D.S.1
  • 97
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med. 1994;179(4):1317-1330. (Pubitemid 24091790)
    • (1994) Journal of Experimental Medicine , vol.179 , Issue.4 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 98
    • 77953229826 scopus 로고    scopus 로고
    • Microparticles as autoadjuvants in the pathogenesis of SLE
    • Pisetsky DS, Lipsky PE. Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol. 2010;6(6):368-372.
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.6 , pp. 368-372
    • Pisetsky, D.S.1    Lipsky, P.E.2
  • 99
    • 84857017558 scopus 로고    scopus 로고
    • Generation and breakdown of soluble ultralarge von Willebrand factor multimers
    • Turner N, Nolasco L, Moake J. Generation and breakdown of soluble ultralarge von Willebrand factor multimers. Semin Thromb Hemost. 2012;38(1):38-46.
    • (2012) Semin Thromb Hemost , vol.38 , Issue.1 , pp. 38-46
    • Turner, N.1    Nolasco, L.2    Moake, J.3
  • 100
    • 78649995651 scopus 로고    scopus 로고
    • Disulfide bond reduction of von Willebrand factor by ADAMTS-13
    • Yeh HC, Zhou Z, Choi H, et al. Disulfide bond reduction of von Willebrand factor by ADAMTS-13. J Thromb Haemost. 2010;8(12):2778-2788.
    • (2010) J Thromb Haemost , vol.8 , Issue.12 , pp. 2778-2788
    • Yeh, H.C.1    Zhou, Z.2    Choi, H.3
  • 101
    • 84866847587 scopus 로고    scopus 로고
    • A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor
    • Navarrete A-M, Casari C, Legendre P, et al. A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor. Blood. 2012;120(13):2723-2732.
    • (2012) Blood , vol.120 , Issue.13 , pp. 2723-2732
    • Navarrete, A.-M.1    Casari, C.2    Legendre, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.