Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: New insights into the prothrombotic nature of HIT

Blood

Volumn 118, Issue 10, 2011, Pages 2882-2888

  Kowalska, M Anna ^a,b   Krishnaswamy, Sriram ^a,c   Rauova, Lubica ^a,c,d   Zhai, Li ^a   Hayes, Vincent ^a   Amirikian, Karine ^a   Esko, Jeffrey D ^e   Bougie, Daniel W ^f   Aster, Richard H ^f   Cines, Douglas B ^c   Poncz, Mortimer ^a,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONAL INSTITUTE OF RHEUMATIC DISEASES   (Slovakia)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CHONDROITIN SULFATE; GLYCOSAMINOGLYCAN; HEPARIN; HEPARIN PLATELET FACTOR 4 ANTIBODY; PROTAMINE SULFATE; THROMBIN; THROMBOCYTE FACTOR 4; THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; THROMBOSIS;

EID: 80052667085     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-335208     Document Type: Article

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