메뉴 건너뛰기




Volumn 185, Issue 7, 2010, Pages 4095-4100

Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 9; INTERLEUKIN 9 MONOCLONAL ANTIBODY; MESSENGER RNA; MONOCLONAL ANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN[35-55] PEPTIDE; PEPTIDE VACCINE; RECOMBINANT INTERLEUKIN 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 77957230475     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000986     Document Type: Article
Times cited : (109)

References (48)
  • 1
    • 0033231305 scopus 로고    scopus 로고
    • Assessment of animal models for MS and demyelinating disease in the design of rational therapy
    • Steinman, L. 1999. Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron 24:511-514.
    • (1999) Neuron , vol.24 , pp. 511-514
    • Steinman, L.1
  • 2
    • 77949656747 scopus 로고    scopus 로고
    • Th17 cells in autoimmune demyelinating disease
    • Segal, B. M. 2010. Th17 cells in autoimmune demyelinating disease. Semin. Immunopathol. 32:71-77.
    • (2010) Semin. Immunopathol. , vol.32 , pp. 71-77
    • Segal, B.M.1
  • 3
    • 42249114634 scopus 로고    scopus 로고
    • + CXC chemokine pathway is essential for the development of central nervous system autoimmune disease
    • + CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J. Exp. Med. 205:811-823.
    • (2008) J. Exp. Med. , vol.205 , pp. 811-823
    • Carlson, T.1    Kroenke, M.2    Rao, P.3    Lane, T.E.4    Segal, B.5
  • 5
    • 34147130293 scopus 로고    scopus 로고
    • Yin and yang interplay of IFN-γ in inflammation and autoimmune disease
    • Zhang, J. 2007. Yin and yang interplay of IFN-γ in inflammation and autoimmune disease. J. Clin. Invest. 117:871-873.
    • (2007) J. Clin. Invest. , vol.117 , pp. 871-873
    • Zhang, J.1
  • 6
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger, A., V. Dardalhon, R. A. Sobel, E. Bettelli, and V. K. Kuchroo. 2009. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183:7169-7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 9
    • 39449128293 scopus 로고    scopus 로고
    • Th17 T cells: Linking innate and adaptive immunity
    • Stockinger, B., M. Veldhoen, and B. Martin. 2007. Th17 T cells: linking innate and adaptive immunity. Semin. Immunol. 19:353-361.
    • (2007) Semin. Immunol. , vol.19 , pp. 353-361
    • Stockinger, B.1    Veldhoen, M.2    Martin, B.3
  • 11
    • 34247895422 scopus 로고    scopus 로고
    • Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    • Nakae, S., Y. Iwakura, H. Suto, and S. J. Galli. 2007. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 81:1258-1268.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1258-1268
    • Nakae, S.1    Iwakura, Y.2    Suto, H.3    Galli, S.J.4
  • 12
    • 67649383126 scopus 로고    scopus 로고
    • Th17 cells in MS and experimental autoimmune encephalomyelitis
    • Hofstetter, H., R. Gold, and H. P. Hartung. 2009. Th17 cells in MS and experimental autoimmune encephalomyelitis. Int. MS J. 16:12-18.
    • (2009) Int. MS J. , vol.16 , pp. 12-18
    • Hofstetter, H.1    Gold, R.2    Hartung, H.P.3
  • 15
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius, D., P. Kivisäkk, B. He, N. Kostulas, V. Ozenci, S. Fredrikson, and H. Link. 1999. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5:101-104.
    • (1999) Mult. Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisäkk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 16
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos, J. S., M. A. Friese, M. J. Craner, J. Palace, J. Newcombe, M. M. Esiri, and L. Fugger. 2008. Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172:146-155.
    • (2008) Am. J. Pathol. , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 18
    • 68149156013 scopus 로고    scopus 로고
    • Nine lives: Plasticity among T helper cell subsets
    • Locksley, R. M. 2009. Nine lives: plasticity among T helper cell subsets. J. Exp. Med. 206:1643-1646.
    • (2009) J. Exp. Med. , vol.206 , pp. 1643-1646
    • Locksley, R.M.1
  • 19
    • 0025336180 scopus 로고
    • Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation
    • Donahue, R. E., Y. C. Yang, and S. C. Clark. 1990. Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation. Blood 75:2271-2275.
    • (1990) Blood , vol.75 , pp. 2271-2275
    • Donahue, R.E.1    Yang, Y.C.2    Clark, S.C.3
  • 22
    • 0027717408 scopus 로고
    • Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice
    • Gessner, A., H. Blum, and M. Röllinghoff. 1993. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 189:419-435.
    • (1993) Immunobiology , vol.189 , pp. 419-435
    • Gessner, A.1    Blum, H.2    Röllinghoff, M.3
  • 26
    • 0034681145 scopus 로고    scopus 로고
    • Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice
    • Richard, M., R. K. Grencis, N. E. Humphreys, J. C. Renauld, and J. Van Snick. 2000. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc. Natl. Acad. Sci. USA 97:767-772.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 767-772
    • Richard, M.1    Grencis, R.K.2    Humphreys, N.E.3    Renauld, J.C.4    Van Snick, J.5
  • 27
    • 53149095836 scopus 로고    scopus 로고
    • + dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis
    • + dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. J. Immunol. 181:2483-2493.
    • (2008) J. Immunol. , vol.181 , pp. 2483-2493
    • Li, H.1    Zhang, G.X.2    Chen, Y.3    Xu, H.4    Fitzgerald, D.C.5    Zhao, Z.6    Rostami, A.7
  • 28
    • 0019830851 scopus 로고
    • Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mastcells
    • Nabel, G., S. J. Galli, A. M. Dvorak, H. F. Dvorak, and H. Cantor. 1981. Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mastcells. Nature 291:332-334.
    • (1981) Nature , vol.291 , pp. 332-334
    • Nabel, G.1    Galli, S.J.2    Dvorak, A.M.3    Dvorak, H.F.4    Cantor, H.5
  • 29
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B., G. X. Zhang, S. Yu, J. Li, X. H. Chen, E. S. Ventura, M. Kamoun, and A. Rostami. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169:7104-7110.
    • (2002) J. Immunol. , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 30
    • 10744230574 scopus 로고    scopus 로고
    • Role of IL-12 receptor β1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis
    • Zhang, G. X., S. Yu, B. Gran, J. Li, I. Siglienti, X. Chen, D. Calida, E. Ventura, M. Kamoun, and A. Rostami. 2003. Role of IL-12 receptor β1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J. Immunol. 171:4485-4492.
    • (2003) J. Immunol. , vol.171 , pp. 4485-4492
    • Zhang, G.X.1    Yu, S.2    Gran, B.3    Li, J.4    Siglienti, I.5    Chen, X.6    Calida, D.7    Ventura, E.8    Kamoun, M.9    Rostami, A.10
  • 33
    • 0023739985 scopus 로고
    • Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity
    • Uyttenhove, C., R. J. Simpson, and J. Van Snick. 1988. Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc. Natl. Acad. Sci. USA 85:6934-6938.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6934-6938
    • Uyttenhove, C.1    Simpson, R.J.2    Van Snick, J.3
  • 37
    • 33646596928 scopus 로고    scopus 로고
    • Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE
    • Liu, Y., I. Teige, B. Birnir, and S. Issazadeh-Navikas. 2006. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 12:518-525.
    • (2006) Nat. Med. , vol.12 , pp. 518-525
    • Liu, Y.1    Teige, I.2    Birnir, B.3    Issazadeh-Navikas, S.4
  • 38
    • 65549123549 scopus 로고    scopus 로고
    • Two first-in-human, openlabel, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers
    • White, B., F. Leon, W. White, and G. Robbie. 2009. Two first-in-human, openlabel, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers. Clin. Ther. 31:728-740.
    • (2009) Clin. Ther. , vol.31 , pp. 728-740
    • White, B.1    Leon, F.2    White, W.3    Robbie, G.4
  • 39
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms
    • Engelhardt, B., and R. M. Ransohoff. 2005. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 26:485-495.
    • (2005) Trends Immunol. , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 44
    • 46049093364 scopus 로고    scopus 로고
    • Th17 cells and autoimmune encephalomyelitis (EAE/MS)
    • Aranami, T., and T. Yamamura. 2008. Th17 cells and autoimmune encephalomyelitis (EAE/MS). Allergol. Int. 57:115-120.
    • (2008) Allergol. Int. , vol.57 , pp. 115-120
    • Aranami, T.1    Yamamura, T.2
  • 45
    • 35748966435 scopus 로고    scopus 로고
    • Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis
    • Uyttenhove, C., C. Sommereyns, I. Théate, T. Michiels, and J. Van Snick. 2007. Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 1110:330-336.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1110 , pp. 330-336
    • Uyttenhove, C.1    Sommereyns, C.2    Théate, I.3    Michiels, T.4    Van Snick, J.5
  • 46
    • 0025306952 scopus 로고
    • Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9)
    • Hültner, L., C. Druez, J. Moeller, C. Uyttenhove, E. Schmitt, E. Rüde, P. Dörmer, and J. Van Snick. 1990. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur. J. Immunol. 20:1413-1416.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1413-1416
    • Hültner, L.1    Druez, C.2    Moeller, J.3    Uyttenhove, C.4    Schmitt, E.5    Rüde, E.6    Dörmer, P.7    Van Snick, J.8
  • 47
    • 1242276212 scopus 로고    scopus 로고
    • Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse
    • Sugimoto, T., Y. Ishikawa, T. Yoshimoto, N. Hayashi, J. Fujimoto, and K. Nakanishi. 2004. Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse. J. Exp. Med. 199:535-545.
    • (2004) J. Exp. Med. , vol.199 , pp. 535-545
    • Sugimoto, T.1    Ishikawa, Y.2    Yoshimoto, T.3    Hayashi, N.4    Fujimoto, J.5    Nakanishi, K.6
  • 48
    • 0032193770 scopus 로고    scopus 로고
    • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production
    • Yoshimoto, T., K. Takeda, T. Tanaka, K. Ohkusu, S. Kashiwamura, H. Okamura, S. Akira, and K. Nakanishi. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 161:3400-3407.
    • (1998) J. Immunol. , vol.161 , pp. 3400-3407
    • Yoshimoto, T.1    Takeda, K.2    Tanaka, T.3    Ohkusu, K.4    Kashiwamura, S.5    Okamura, H.6    Akira, S.7    Nakanishi, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.