ATP binding enables broad antibiotic selectivity of aminoglycoside phosphotransferase(3′)-IIIa: An elastic network analysis

Journal of Molecular Biology

Volumn 409, Issue 3, 2011, Pages 450-465

  Wieninger, Silke A ^a   Serpersu, Engin H ^b   Ullmann, G Matthias ^a  

^a UNIVERSITÄT BAYREUTH   (Germany)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

antibiotic resistance; conformational frustration; dynamic protein domains; ligand binding; normal mode analysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE; AMINOGLYCOSIDE PHOSPHOTRANSFERASE(3') IIIA; BACTERIAL ENZYME; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG BINDING; ENTHALPY; ENZYME BINDING; ISOTHERMAL TITRATION CALORIMETRY; KERNEL METHOD; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN;

BACTERIA (MICROORGANISMS);

EID: 79956095443     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.03.061     Document Type: Article

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