메뉴 건너뛰기




Volumn 225, Issue 2, 2012, Pages 381-387

Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide - Induced cytokine production in monocytes of hypercholesterolemic patients

Author keywords

Ezetimibe; Interleukin 1 ; Interleukin 6; Oxidized LDL; Simvastatin; Toll like receptors

Indexed keywords

CYTOKINE; EZETIMIBE PLUS SIMVASTATIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 84869496994     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.08.037     Document Type: Article
Times cited : (53)

References (79)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 2
    • 34548583437 scopus 로고    scopus 로고
    • Innate immunity, macrophage activation, and atherosclerosis
    • Yan Z.Q., Hansson G.K. Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 2007, 219:187-203.
    • (2007) Immunol Rev , vol.219 , pp. 187-203
    • Yan, Z.Q.1    Hansson, G.K.2
  • 4
    • 0037066502 scopus 로고    scopus 로고
    • Jr., Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R., Janeway C.A. Jr., Decoding the patterns of self and nonself by the innate immune system. Science 2002, 296:298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway, C.A.2
  • 5
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A., Ulevitch R.J. Toll-like receptors in the induction of the innate immune response. Nature 2000, 406:782-787.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 6
    • 38049029104 scopus 로고    scopus 로고
    • Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids
    • Liu X., Ukai T., Yumoto H., et al. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis 2008, 196:146-154.
    • (2008) Atherosclerosis , vol.196 , pp. 146-154
    • Liu, X.1    Ukai, T.2    Yumoto, H.3
  • 7
    • 73349128100 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis
    • Monaco C., Gregan S.M., Navin T.J., Foxwell B.M., Davies A.H., Feldmann M. Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. Circulation 2009, 120:2462-2469.
    • (2009) Circulation , vol.120 , pp. 2462-2469
    • Monaco, C.1    Gregan, S.M.2    Navin, T.J.3    Foxwell, B.M.4    Davies, A.H.5    Feldmann, M.6
  • 8
    • 39549120661 scopus 로고    scopus 로고
    • Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events
    • Mullick A.E., Soldau K., Kiosses W.B., Bell T.A., Tobias P.S., Curtiss L.K. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med 2008, 205:373-383.
    • (2008) J Exp Med , vol.205 , pp. 373-383
    • Mullick, A.E.1    Soldau, K.2    Kiosses, W.B.3    Bell, T.A.4    Tobias, P.S.5    Curtiss, L.K.6
  • 9
    • 0035910010 scopus 로고    scopus 로고
    • Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL
    • Xu X.H., Shah P.K., Faure E., et al. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation 2001, 104:3103-3108.
    • (2001) Circulation , vol.104 , pp. 3103-3108
    • Xu, X.H.1    Shah, P.K.2    Faure, E.3
  • 10
    • 3242710174 scopus 로고    scopus 로고
    • Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    • Michelsen K.S., Wong M.H., Shah P.K., et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 2004, 101:10679-10684.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10679-10684
    • Michelsen, K.S.1    Wong, M.H.2    Shah, P.K.3
  • 11
    • 3242728901 scopus 로고    scopus 로고
    • Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
    • Bjorkbacka H., Kunjathoor V.V., Moore K.J., et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 2004, 10:416-421.
    • (2004) Nat Med , vol.10 , pp. 416-421
    • Bjorkbacka, H.1    Kunjathoor, V.V.2    Moore, K.J.3
  • 12
    • 27644568878 scopus 로고    scopus 로고
    • Modulation of atherosclerosis in mice by Toll-like receptor 2
    • Mullick A.E., Tobias P.S., Curtiss L.K. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 2005, 115:3149-3156.
    • (2005) J Clin Invest , vol.115 , pp. 3149-3156
    • Mullick, A.E.1    Tobias, P.S.2    Curtiss, L.K.3
  • 14
    • 33644867555 scopus 로고    scopus 로고
    • Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease
    • Geng H.L., Lu H.Q., Zhang L.Z., et al. Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease. Clin Exp Immunol 2006, 143:269-273.
    • (2006) Clin Exp Immunol , vol.143 , pp. 269-273
    • Geng, H.L.1    Lu, H.Q.2    Zhang, L.Z.3
  • 15
    • 19644390754 scopus 로고    scopus 로고
    • Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome
    • Methe H., Kim J.O., Kofler S., Weis M., Nabauer M., Koglin J. Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation 2005, 111:2654-2661.
    • (2005) Circulation , vol.111 , pp. 2654-2661
    • Methe, H.1    Kim, J.O.2    Kofler, S.3    Weis, M.4    Nabauer, M.5    Koglin, J.6
  • 16
    • 77049098321 scopus 로고    scopus 로고
    • High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease
    • Kuwahata S., Fujita S., Orihara K., et al. High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease. Atherosclerosis 2010, 209:248-254.
    • (2010) Atherosclerosis , vol.209 , pp. 248-254
    • Kuwahata, S.1    Fujita, S.2    Orihara, K.3
  • 17
    • 34548160715 scopus 로고    scopus 로고
    • Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina
    • Pasini A.F., Anselmi M., Garbin U., et al. Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina. Arterioscler Thromb Vasc Biol 2007, 27:1991-1997.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1991-1997
    • Pasini, A.F.1    Anselmi, M.2    Garbin, U.3
  • 18
    • 33845778417 scopus 로고    scopus 로고
    • Association between Toll-like receptors and the extent and severity of coronary artery disease in patients with stable angina
    • Mizoguchi E., Orihara K., Hamasaki S., et al. Association between Toll-like receptors and the extent and severity of coronary artery disease in patients with stable angina. Coron Artery Dis 2007, 18:31-38.
    • (2007) Coron Artery Dis , vol.18 , pp. 31-38
    • Mizoguchi, E.1    Orihara, K.2    Hamasaki, S.3
  • 19
    • 0038179661 scopus 로고    scopus 로고
    • Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events
    • Boekholdt S.M., Agema W.R., Peters R.J., et al. Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation 2003, 107:2416-2421.
    • (2003) Circulation , vol.107 , pp. 2416-2421
    • Boekholdt, S.M.1    Agema, W.R.2    Peters, R.J.3
  • 20
    • 1342278730 scopus 로고    scopus 로고
    • Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events
    • Ameziane N., Beillat T., Verpillat P., et al. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 2003, 23:e61-e64.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23
    • Ameziane, N.1    Beillat, T.2    Verpillat, P.3
  • 21
    • 0037130195 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and atherogenesis
    • Kiechl S., Lorenz E., Reindl M., et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002, 347:185-192.
    • (2002) N Engl J Med , vol.347 , pp. 185-192
    • Kiechl, S.1    Lorenz, E.2    Reindl, M.3
  • 22
    • 34247859301 scopus 로고    scopus 로고
    • Toll receptor polymorphisms and carotid artery intima-media thickness
    • Labrum R., Bevan S., Sitzer M., Lorenz M., Markus H.S. Toll receptor polymorphisms and carotid artery intima-media thickness. Stroke 2007, 38:1179-1184.
    • (2007) Stroke , vol.38 , pp. 1179-1184
    • Labrum, R.1    Bevan, S.2    Sitzer, M.3    Lorenz, M.4    Markus, H.S.5
  • 24
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
    • Takemoto M., Liao J.K. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001, 21:1712-1719.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 25
    • 23944445364 scopus 로고    scopus 로고
    • Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol
    • Liao J.K. Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol. Am J Cardiol 2005, 96:24F-33F.
    • (2005) Am J Cardiol , vol.96
    • Liao, J.K.1
  • 26
    • 33745935660 scopus 로고    scopus 로고
    • Modulation of toll-like receptor expression: a further effect of statins?
    • Alves-Filho J.C., Cunha F.Q. Modulation of toll-like receptor expression: a further effect of statins?. Arterioscler Thromb Vasc Biol 2006, 26:e128.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26
    • Alves-Filho, J.C.1    Cunha, F.Q.2
  • 27
    • 79951652753 scopus 로고    scopus 로고
    • The effect of simvastatin alone versus simvastatin plus ezetimibe on the concentration of small dense low-density lipoprotein cholesterol in subjects with primary hypercholesterolemia
    • Florentin M., Liberopoulos E.N., Moutzouri E., Rizos C.V., Tselepis A.D., Elisaf M.S. The effect of simvastatin alone versus simvastatin plus ezetimibe on the concentration of small dense low-density lipoprotein cholesterol in subjects with primary hypercholesterolemia. Curr Med Res Opin 2011, 27:685-692.
    • (2011) Curr Med Res Opin , vol.27 , pp. 685-692
    • Florentin, M.1    Liberopoulos, E.N.2    Moutzouri, E.3    Rizos, C.V.4    Tselepis, A.D.5    Elisaf, M.S.6
  • 28
    • 0141566768 scopus 로고    scopus 로고
    • Statins differ in their ability to block NF-kappaB activation in human blood monocytes
    • Hilgendorff A., Muth H., Parviz B., et al. Statins differ in their ability to block NF-kappaB activation in human blood monocytes. Int J Clin Pharmacol Ther 2003, 41:397-401.
    • (2003) Int J Clin Pharmacol Ther , vol.41 , pp. 397-401
    • Hilgendorff, A.1    Muth, H.2    Parviz, B.3
  • 29
    • 0037504445 scopus 로고    scopus 로고
    • Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial
    • Ballantyne C.M., Houri J., Notarbartolo A., et al. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003, 107:2409-2415.
    • (2003) Circulation , vol.107 , pp. 2409-2415
    • Ballantyne, C.M.1    Houri, J.2    Notarbartolo, A.3
  • 30
    • 77949917890 scopus 로고    scopus 로고
    • Pleiotropic effects of ezetimibe: do they really exist?
    • Kalogirou M., Tsimihodimos V., Elisaf M. Pleiotropic effects of ezetimibe: do they really exist?. Eur J Pharmacol 2010, 633:62-70.
    • (2010) Eur J Pharmacol , vol.633 , pp. 62-70
    • Kalogirou, M.1    Tsimihodimos, V.2    Elisaf, M.3
  • 31
    • 0037126526 scopus 로고    scopus 로고
    • Evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 2002, 106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 32
    • 0036159510 scopus 로고    scopus 로고
    • Atorvastatin preferentially reduces LDL-associated platelet-activating factor acetylhydrolase activity in dyslipidemias of type IIA and type IIB
    • Tsimihodimos V., Karabina S.A., Tambaki A.P., et al. Atorvastatin preferentially reduces LDL-associated platelet-activating factor acetylhydrolase activity in dyslipidemias of type IIA and type IIB. Arterioscler Thromb Vasc Biol 2002, 22:306-311.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 306-311
    • Tsimihodimos, V.1    Karabina, S.A.2    Tambaki, A.P.3
  • 33
    • 33845597078 scopus 로고    scopus 로고
    • Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia
    • Tsouli S.G., Kiortsis D.N., Lourida E.S., et al. Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia. J Lipid Res 2006, 47:2208-2214.
    • (2006) J Lipid Res , vol.47 , pp. 2208-2214
    • Tsouli, S.G.1    Kiortsis, D.N.2    Lourida, E.S.3
  • 34
    • 33746138923 scopus 로고    scopus 로고
    • Reduced expression of Toll-like receptor 4 contributes to impaired cytokine response of monocytes in uremic patients
    • Ando M., Shibuya A., Tsuchiya K., Akiba T., Nitta K. Reduced expression of Toll-like receptor 4 contributes to impaired cytokine response of monocytes in uremic patients. Kidney Int 2006, 70:358-362.
    • (2006) Kidney Int , vol.70 , pp. 358-362
    • Ando, M.1    Shibuya, A.2    Tsuchiya, K.3    Akiba, T.4    Nitta, K.5
  • 35
    • 0023008846 scopus 로고
    • Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes
    • Misumi Y., Miki K., Takatsuki A., Tamura G., Ikehara Y. Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J Biol Chem 1986, 261:11398-11403.
    • (1986) J Biol Chem , vol.261 , pp. 11398-11403
    • Misumi, Y.1    Miki, K.2    Takatsuki, A.3    Tamura, G.4    Ikehara, Y.5
  • 36
    • 33750840014 scopus 로고    scopus 로고
    • Macrophage activation: role of toll-like receptors, nitric oxide, and nuclear factor kappa B
    • Billack B. Macrophage activation: role of toll-like receptors, nitric oxide, and nuclear factor kappa B. Am J Pharm Educ 2006, 70:102.
    • (2006) Am J Pharm Educ , vol.70 , pp. 102
    • Billack, B.1
  • 37
    • 33746878591 scopus 로고    scopus 로고
    • Toll-like receptors and atherosclerosis: oxidized LDL as an endogenous Toll-like receptor ligand
    • Miller Y.I. Toll-like receptors and atherosclerosis: oxidized LDL as an endogenous Toll-like receptor ligand. Future Cardiol 2005, 1:785-792.
    • (2005) Future Cardiol , vol.1 , pp. 785-792
    • Miller, Y.I.1
  • 38
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller Y.I., Viriyakosol S., Binder C.J., Feramisco J.R., Kirkland T.N., Witztum J.L. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem 2003, 278:1561-1568.
    • (2003) J Biol Chem , vol.278 , pp. 1561-1568
    • Miller, Y.I.1    Viriyakosol, S.2    Binder, C.J.3    Feramisco, J.R.4    Kirkland, T.N.5    Witztum, J.L.6
  • 39
    • 20144385204 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages
    • Miller Y.I., Viriyakosol S., Worrall D.S., Boullier A., Butler S., Witztum J.L. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol 2005, 25:1213-1219.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1213-1219
    • Miller, Y.I.1    Viriyakosol, S.2    Worrall, D.S.3    Boullier, A.4    Butler, S.5    Witztum, J.L.6
  • 41
    • 56149118396 scopus 로고    scopus 로고
    • Acute modulation of toll-like receptors by insulin
    • Ghanim H., Mohanty P., Deopurkar R., et al. Acute modulation of toll-like receptors by insulin. Diabetes Care 2008, 31:1827-1831.
    • (2008) Diabetes Care , vol.31 , pp. 1827-1831
    • Ghanim, H.1    Mohanty, P.2    Deopurkar, R.3
  • 42
    • 77953060025 scopus 로고    scopus 로고
    • Increased toll-like receptor activation and TLR ligands in recently diagnosed type 2 diabetes subjects
    • Dasu M.R., Devaraj S., Park S., Jialal I. Increased toll-like receptor activation and TLR ligands in recently diagnosed type 2 diabetes subjects. Diabetes Care 2010, 33:861-868.
    • (2010) Diabetes Care , vol.33 , pp. 861-868
    • Dasu, M.R.1    Devaraj, S.2    Park, S.3    Jialal, I.4
  • 43
    • 58149333718 scopus 로고    scopus 로고
    • High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
    • Dasu M.R., Devaraj S., Zhao L., Hwang D.H., Jialal I. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes 2008, 57:3090-3098.
    • (2008) Diabetes , vol.57 , pp. 3090-3098
    • Dasu, M.R.1    Devaraj, S.2    Zhao, L.3    Hwang, D.H.4    Jialal, I.5
  • 44
    • 67650682810 scopus 로고    scopus 로고
    • Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes
    • Devaraj S., Dasu M.R., Park S.H., Jialal I. Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes. Diabetologia 2009, 52:1665-1668.
    • (2009) Diabetologia , vol.52 , pp. 1665-1668
    • Devaraj, S.1    Dasu, M.R.2    Park, S.H.3    Jialal, I.4
  • 45
    • 72249106180 scopus 로고    scopus 로고
    • Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance
    • Ghanim H., Abuaysheh S., Sia C.L., et al. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care 2009, 32:2281-2287.
    • (2009) Diabetes Care , vol.32 , pp. 2281-2287
    • Ghanim, H.1    Abuaysheh, S.2    Sia, C.L.3
  • 46
    • 77951955627 scopus 로고    scopus 로고
    • Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3
    • Deopurkar R., Ghanim H., Friedman J., et al. Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 2010, 33:991-997.
    • (2010) Diabetes Care , vol.33 , pp. 991-997
    • Deopurkar, R.1    Ghanim, H.2    Friedman, J.3
  • 47
    • 53049087305 scopus 로고    scopus 로고
    • Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression
    • Hodgkinson C.P., Ye S. Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. Pharmacogenet Genom 2008, 18:803-813.
    • (2008) Pharmacogenet Genom , vol.18 , pp. 803-813
    • Hodgkinson, C.P.1    Ye, S.2
  • 49
    • 21544452747 scopus 로고    scopus 로고
    • Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes
    • Methe H., Kim J.O., Kofler S., Nabauer M., Weis M. Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. Arterioscler Thromb Vasc Biol 2005, 25:1439-1445.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1439-1445
    • Methe, H.1    Kim, J.O.2    Kofler, S.3    Nabauer, M.4    Weis, M.5
  • 50
    • 79955753831 scopus 로고    scopus 로고
    • Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells
    • Wang Y., Zhang M.X., Meng X., et al. Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells. Am J Physiol Heart Circ Physiol 2011, 300:H1743-H1752.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Wang, Y.1    Zhang, M.X.2    Meng, X.3
  • 51
    • 2942741132 scopus 로고    scopus 로고
    • The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription
    • Teusch N., Lombardo E., Eddleston J., Knaus U.G. The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription. J Immunol 2004, 173:507-514.
    • (2004) J Immunol , vol.173 , pp. 507-514
    • Teusch, N.1    Lombardo, E.2    Eddleston, J.3    Knaus, U.G.4
  • 52
    • 33745463739 scopus 로고    scopus 로고
    • A comprehensive map of the toll-like receptor signaling network
    • Oda K., Kitano H. A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol 2006, 2:0015.
    • (2006) Mol Syst Biol , vol.2 , pp. 0015
    • Oda, K.1    Kitano, H.2
  • 53
    • 38349158666 scopus 로고    scopus 로고
    • The toll of Toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis
    • Curtiss L.K., Tobias P.S. The toll of Toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis. Curr Drug Targets 2007, 8:1230-1238.
    • (2007) Curr Drug Targets , vol.8 , pp. 1230-1238
    • Curtiss, L.K.1    Tobias, P.S.2
  • 54
    • 83555163946 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients
    • Lin H., Xiao Y., Chen G., et al. HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. Rheumatol Int 2011, 31:1451-1458.
    • (2011) Rheumatol Int , vol.31 , pp. 1451-1458
    • Lin, H.1    Xiao, Y.2    Chen, G.3
  • 55
    • 33750360916 scopus 로고    scopus 로고
    • Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo
    • Niessner A., Steiner S., Speidl W.S., et al. Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo. Atherosclerosis 2006, 189:408-413.
    • (2006) Atherosclerosis , vol.189 , pp. 408-413
    • Niessner, A.1    Steiner, S.2    Speidl, W.S.3
  • 56
    • 79959214994 scopus 로고    scopus 로고
    • Achievement of recommended lipid and lipoprotein levels with combined ezetimibe/statin therapy versus statin alone in patients with and without diabetes
    • Guyton J.R., Betteridge D.J., Farnier M., et al. Achievement of recommended lipid and lipoprotein levels with combined ezetimibe/statin therapy versus statin alone in patients with and without diabetes. Diab Vasc Dis Res 2011, 8:160-172.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 160-172
    • Guyton, J.R.1    Betteridge, D.J.2    Farnier, M.3
  • 57
    • 84863633158 scopus 로고    scopus 로고
    • Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin
    • Pesaro A.E., Serrano C.V., Fernandes J.L., et al. Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin. Int J Cardiol 2012, 158:400-404.
    • (2012) Int J Cardiol , vol.158 , pp. 400-404
    • Pesaro, A.E.1    Serrano, C.V.2    Fernandes, J.L.3
  • 58
    • 80051793346 scopus 로고    scopus 로고
    • Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events
    • Undas A., Machnik A., Potaczek D.P., Wypasek E., Zmudka K., Tracz W. Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events. J Cardiovasc Pharmacol 2011, 58:167-172.
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 167-172
    • Undas, A.1    Machnik, A.2    Potaczek, D.P.3    Wypasek, E.4    Zmudka, K.5    Tracz, W.6
  • 59
    • 83855164175 scopus 로고    scopus 로고
    • The effect of ezetimibe, administered alone or in combination with simvastatin, on lymphocyte cytokine release in patients with elevated cholesterol levels
    • Krysiak R., Zmuda W., Okopien B. The effect of ezetimibe, administered alone or in combination with simvastatin, on lymphocyte cytokine release in patients with elevated cholesterol levels. J Intern Med 2012, 271:32-42.
    • (2012) J Intern Med , vol.271 , pp. 32-42
    • Krysiak, R.1    Zmuda, W.2    Okopien, B.3
  • 60
    • 75749114117 scopus 로고    scopus 로고
    • Pleiotropic effects with equivalent low-density lipoprotein cholesterol reduction: comparative study between simvastatin and simvastatin/ezetimibe coadministration
    • Araujo D.B., Bertolami M.C., Ferreira W.P., et al. Pleiotropic effects with equivalent low-density lipoprotein cholesterol reduction: comparative study between simvastatin and simvastatin/ezetimibe coadministration. J Cardiovasc Pharmacol 2010, 55:1-5.
    • (2010) J Cardiovasc Pharmacol , vol.55 , pp. 1-5
    • Araujo, D.B.1    Bertolami, M.C.2    Ferreira, W.P.3
  • 61
    • 79956031420 scopus 로고    scopus 로고
    • Ezetimibe treatment lowers indicators of oxidative stress in hypercholesterolemic subjects with high oxidative stress
    • Kostapanos M.S., Spyrou A.T., Tellis C.C., et al. Ezetimibe treatment lowers indicators of oxidative stress in hypercholesterolemic subjects with high oxidative stress. Lipids 2011, 46:341-348.
    • (2011) Lipids , vol.46 , pp. 341-348
    • Kostapanos, M.S.1    Spyrou, A.T.2    Tellis, C.C.3
  • 62
    • 35148866515 scopus 로고    scopus 로고
    • Differential effect of hypolipidemic drugs on lipoprotein-associated phospholipase A2
    • Saougos V.G., Tambaki A.P., Kalogirou M., et al. Differential effect of hypolipidemic drugs on lipoprotein-associated phospholipase A2. Arterioscler Thromb Vasc Biol 2007, 27:2236-2243.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2236-2243
    • Saougos, V.G.1    Tambaki, A.P.2    Kalogirou, M.3
  • 63
    • 79751486106 scopus 로고    scopus 로고
    • The effects of statin monotherapy and low-dose statin/ezetimibe on lipoprotein-associated phospholipase A
    • Lee S.H., Kang S.M., Park S., Jang Y., Chung N., Choi D. The effects of statin monotherapy and low-dose statin/ezetimibe on lipoprotein-associated phospholipase A. Clin Cardiol 2011, 34:108-112.
    • (2011) Clin Cardiol , vol.34 , pp. 108-112
    • Lee, S.H.1    Kang, S.M.2    Park, S.3    Jang, Y.4    Chung, N.5    Choi, D.6
  • 64
    • 59449101190 scopus 로고    scopus 로고
    • The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia
    • Nakou E.S., Filippatos T.D., Kiortsis D.N., et al. The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia. Expert Opin Pharmacother 2008, 9:3151-3158.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 3151-3158
    • Nakou, E.S.1    Filippatos, T.D.2    Kiortsis, D.N.3
  • 65
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha M., Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001, 13:85-94.
    • (2001) Cell Signal , vol.13 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 66
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 67
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S., Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 69
    • 33645891172 scopus 로고    scopus 로고
    • Cytokines in atherosclerosis: pathogenic and regulatory pathways
    • Tedgui A., Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 2006, 86:515-581.
    • (2006) Physiol Rev , vol.86 , pp. 515-581
    • Tedgui, A.1    Mallat, Z.2
  • 70
    • 33846846717 scopus 로고    scopus 로고
    • Oxidised phospholipid regulation of Toll-like receptor signalling
    • Erridge C., Spickett C.M. Oxidised phospholipid regulation of Toll-like receptor signalling. Redox Rep 2007, 12:76-80.
    • (2007) Redox Rep , vol.12 , pp. 76-80
    • Erridge, C.1    Spickett, C.M.2
  • 71
    • 33751171875 scopus 로고    scopus 로고
    • Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease
    • Tsimikas S. Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease. Am J Cardiol 2006, 98:9P-17P.
    • (2006) Am J Cardiol , vol.98
    • Tsimikas, S.1
  • 72
    • 28444431551 scopus 로고    scopus 로고
    • Oxidized phospholipids as triggers of inflammation in atherosclerosis
    • Leitinger N. Oxidized phospholipids as triggers of inflammation in atherosclerosis. Mol Nutr Food Res 2005, 49:1063-1071.
    • (2005) Mol Nutr Food Res , vol.49 , pp. 1063-1071
    • Leitinger, N.1
  • 73
    • 54049122271 scopus 로고    scopus 로고
    • Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition
    • Erridge C., Kennedy S., Spickett C.M., Webb D.J. Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. J Biol Chem 2008, 283:24748-24759.
    • (2008) J Biol Chem , vol.283 , pp. 24748-24759
    • Erridge, C.1    Kennedy, S.2    Spickett, C.M.3    Webb, D.J.4
  • 74
    • 10744226347 scopus 로고    scopus 로고
    • Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2
    • Walton K.A., Cole A.L., Yeh M., et al. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol 2003, 23:1197-1203.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1197-1203
    • Walton, K.A.1    Cole, A.L.2    Yeh, M.3
  • 75
    • 3142544785 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein blocks lipopolysaccharide-induced interferon beta synthesis in human macrophages by interfering with IRF3 activation
    • Marson A., Lawn R.M., Mikita T. Oxidized low density lipoprotein blocks lipopolysaccharide-induced interferon beta synthesis in human macrophages by interfering with IRF3 activation. J Biol Chem 2004, 279:28781-28788.
    • (2004) J Biol Chem , vol.279 , pp. 28781-28788
    • Marson, A.1    Lawn, R.M.2    Mikita, T.3
  • 76
    • 78650659753 scopus 로고    scopus 로고
    • Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation
    • Oskolkova O.V., Afonyushkin T., Preinerstorfer B., et al. Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation. J Immunol 2010, 185:7706-7712.
    • (2010) J Immunol , vol.185 , pp. 7706-7712
    • Oskolkova, O.V.1    Afonyushkin, T.2    Preinerstorfer, B.3
  • 77
    • 0035574650 scopus 로고    scopus 로고
    • In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products
    • Diomede L., Albani D., Sottocorno M., et al. In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 2001, 21:1327-1332.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1327-1332
    • Diomede, L.1    Albani, D.2    Sottocorno, M.3
  • 78
    • 79955005698 scopus 로고    scopus 로고
    • The effect of ezetimibe and simvastatin on monocyte cytokine release in patients with isolated hypercholesterolemia
    • Krysiak R., Okopien B. The effect of ezetimibe and simvastatin on monocyte cytokine release in patients with isolated hypercholesterolemia. J Cardiovasc Pharmacol 2011, 57:505-512.
    • (2011) J Cardiovasc Pharmacol , vol.57 , pp. 505-512
    • Krysiak, R.1    Okopien, B.2
  • 79
    • 84864381351 scopus 로고    scopus 로고
    • Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans
    • [Epub ahead of print]
    • Nochioka K., Tanaka S.I., Miura M., et al. Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. Circ J 2012 Apr 28, [Epub ahead of print].
    • (2012) Circ J
    • Nochioka, K.1    Tanaka, S.I.2    Miura, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.