Toll receptor polymorphisms and carotid artery intima-media thickness

Stroke

Volumn 38, Issue 4, 2007, Pages 1179-1184

  Labrum, Robyn ^a   Bevan, Steve ^a   Sitzer, Matthias ^b   Lorenz, Matthias ^b   Markus, Hugh S ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Carotid artery; Genetics; Inflammation; Ultrasound

Indexed keywords

C REACTIVE PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CAROTID ARTERY; CONTROLLED STUDY; DIABETES MELLITUS; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENE; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOLL LIKE RECEPTOR 2 GENE; TOLL LIKE RECEPTOR 4 GENE; CAROTID ARTERY DISEASE; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; INTIMA; METABOLISM; MIDDLE AGED; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; TUNICA MEDIA; UNITED KINGDOM;

ADULT; C-REACTIVE PROTEIN; CAROTID ARTERIES; CAROTID ARTERY DISEASES; COHORT STUDIES; DIABETES COMPLICATIONS; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GREAT BRITAIN; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; SMOKING; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUNICA INTIMA; TUNICA MEDIA;

EID: 34247859301     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000260184.85257.2b     Document Type: Article

References (32)

1. Jerrard-Dunne P, Sitzer M, Risley P, Buehler A, von Kegler S, Markus HS. Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers. Stroke. 2004;35:2438-2443.
2. Markus HS, Labrum R, Bevan S, Reindl M, Egger G, Wiedermann CJ, Schwartz D, Lorenz E, Xu Q, Kiechl S, Willeit J. Genetic and acquired inflammatory conditions are synergistically associated with early atherosclerosis. Stroke. 2006;3:2253-2259
3. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-680.
4. Edfeldt K, Swedenborg J, Hansson GK, Yan ZQ. Expression of Toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation. 2002;105:1158-1161.
5. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol. 1999;11:13-18.
6. Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997;388:394-397.
7. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem. 1999;274:10689-10692.
8. Bjorkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004;10:416.
9. Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 204;101:10679.
10. Xu XH, Shah PK, Faure E, Equils O, Thomas L, Fishbein MC, Luthringer D, Xu XP, Rajavashisth TB, Yano J, Kaul S, Arditi M. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation. 2001;104:3103-3108.
11. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25:187-191.
12. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. 2002;347:185-192.
13. Boekholdt SM, Agema WR, Peters RJ, Zwinderman AH, van der Wall EE, Reitsma PH, Kastelein JJ, Jukema JW; REgression GRowth Evaluation Statin Study Group. Variants of Toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation. 2003;107:2416-2421.
14. Morange PE, Tiret L, Saut N, Luc G, Arveiler D, Ferrieres J, Amouyel P, Evans A, Ducimetiere P, Cambien F, Juhan-Vague I; PRIME Study Group. TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study. Eur J Hum Genet. 2004;12:1041-1049.
15. Norata GD, Garlaschelli K, Ongari M, Raselli S, Grigore L, Benvenuto F, Maggi FM, Catapano AL. Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS. J Intern Med. 2005;258:21-27.
16. Reismann P, Lichy C, Rudofsky G, Humpert PM, Genius J, Si TD, Dorfer C, Grau AJ, Hamann A, Hacke W, Nawroth PP, Bierhaus A. Lack of association between polymorphisms of the Toll-like receptor 4 gene and cerebral ischemia. J Neurol. 2004;251:853-858.
17. Hunter DJ. Gene-environment interactions in human diseases. Nat Rev Genet. 2005;6:287-298.
18. Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun. 2002;68:6398-6401.
19. Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O. The Arg753GLn polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J. 2004;23:219-223.
20. Ahmad-Nejad P, Mrabet-Dahbi S, Breuer K, Klotz M, Werfel T, Herz U, Heeg K, Neumaier M, Renz H. The Toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol. 2004;113:565-567.
21. Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrlander C, Nowak D, Martinez FD; ALEX Study Team. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol. 2004;113:482-488.
22. Hamann L, Gomma A, Schroder NW, Stamme C, Glaeser C, Schulz S, Gross M, Anker SD, Fox K, Schumann RR. A frequent Toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med. 2005;83:478-485.
23. Sitzer M, Puac D, Buehler A, Steckel DA, von Kegler S, Markus HS, Steinmetz H. Internal carotid artery angle of origin. A novel risk factor for early carotid atherosclerosis. Stroke. 2003;34:950-955.
24. Helmert U, Shea S, Herman B, Greiser E. Relationship of social class characteristics and risk factors for coronary heart disease in West Germany. Public Health. 1990;104:399-416.
25. Pickering TG. Blood pressure measurement and detection of hypertension. Lancet. 1994;344:31-35.
26. Sitzer M, Markus HS, Mendall MA, Liehr R, Knorr U, Steinmetz H. C-reactive protein and carotid intimal medial thickness in a community population. J Cardiovasc Risk. 2002;9:97-103.
27. Sitzer M, Skutta M, Siebler M, Sitzer G, Siegrist J, Steinmetz H. Modifiable stroke risk factors in volunteers willing to participate in a prevention program. Neuroepidemiology. 1998;17:179-187.
28. Bonithon-Kopp C, Scarabin PY, Taquet A, Touboul PJ, Malmejac A, Guize L. Risk factors for early carotid atherosclerosis in middle-aged French women. Arterioscler Thromb Vasc Biol. 1991;11:966-972.
29. Mannami T, Baba B, Ogata J. Potential of carotid enlargement as a useful indicator affected by high blood pressure in a large general population of a Japanese city. The Suita Study. Stroke. 2000;31:2958-2965.
30. Hunt KJ, Duggirala R, Goring HH, Williams JT, Almasy L, Blangero J, O'Leary DH, Stern MP. Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study. Stroke. 2002;33:2775-2780.
31. Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006;37:87-92.
32. Mackinnon AD, Jerrard-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus HS. Rates and determinants of site-specific progression of carotid artery intima media thickness: the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2004;35:2150-2154.