HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients

Rheumatology International

Volumn 31, Issue 11, 2011, Pages 1451-1458

  Lin, Haobo ^a   Xiao, Youjun ^a   Chen, Guoqiang ^a   Fu, Di ^a   Ye, Yujin ^a   Liang, Liuqin ^a   Fan, Jinjin ^a   Yang, Xiuyan ^a   Sun, Lin ^b   Xu, Hanshi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Inflammation; Rheumatoid arthritis; Rho; Statin; Toll like receptor

Indexed keywords

GERANYLGERANYL PYROPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MEVALONIC ACID; PEPTIDOGLYCAN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; COLORIMETRY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA BINDING; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NF-KAPPA B; PEPTIDOGLYCAN; PREDNISONE; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIMVASTATIN; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTOR 2; TRANSFECTION;

EID: 83555163946     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1510-6     Document Type: Article

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