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Volumn 61, Issue 12, 2012, Pages 1666-1673

VEGF and angiopoietins in diabetic glomerulopathy: How far for a new treatment?

Author keywords

Angiopoietins; Diabetic nephropathy; Therapy; Vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; BEVACIZUMAB; ENDOSTATIN; RANIBIZUMAB; TUMSTATIN; VASCULOTROPIN; VASCULOTROPIN A;

EID: 84869492634     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.04.004     Document Type: Review
Times cited : (43)

References (77)
  • 1
    • 0032737294 scopus 로고    scopus 로고
    • End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
    • E. Ritz, I. Rychlik, and F. Locatelli End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions Am J Kidney Dis 34 1999 795 808 (Pubitemid 29521694)
    • (1999) American Journal of Kidney Diseases , vol.34 , Issue.5 , pp. 795-808
    • Ritz, E.1    Rychlik, I.2    Locatelli, F.3    Halimi, S.4
  • 2
    • 30944432192 scopus 로고    scopus 로고
    • Chronic renal diseases as a public health problem: Epidemiology, social, and economic implications
    • A. Schieppati, and G. Remuzzi Chronic renal diseases as a public health problem: epidemiology, social, and economic implications Kidney Int Suppl 98 2005 S7 S10
    • (2005) Kidney Int Suppl , vol.98
    • Schieppati, A.1    Remuzzi, G.2
  • 3
    • 0030042173 scopus 로고    scopus 로고
    • Prevalence and risk factors for micro- and macroalbuminuria in an Italian population-based cohort of NIDDM subjects
    • G. Bruno, P. Cavallo-Perin, and G. Bargero Prevalence and risk factors for micro- and macroalbuminuria in an Italian population-based cohort of NIDDM subjects Diabetes Care 19 1996 43 47
    • (1996) Diabetes Care , vol.19 , pp. 43-47
    • Bruno, G.1    Cavallo-Perin, P.2    Bargero, G.3
  • 4
    • 33947407755 scopus 로고    scopus 로고
    • Assessing the prevalence, monitoring and management of chronic kidney disease in patients with diabetes compared with those without diabetes in general practice
    • DOI 10.1111/j.1464-5491.2007.02075.x
    • J.P. New, R.J. Middleton, and B. Klebe Assessing the prevalence, monitoring and management of chronic kidney disease in patients with diabetes compared with those without diabetes in general practice Diabet Med 24 2007 364 369 (Pubitemid 46452394)
    • (2007) Diabetic Medicine , vol.24 , Issue.4 , pp. 364-369
    • New, J.P.1    Middleton, R.J.2    Klebe, B.3    Farmer, C.K.T.4    De Lusignan, S.5    Stevens, P.E.6    O'Donoghue, D.J.7
  • 6
    • 0037213037 scopus 로고    scopus 로고
    • Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64)
    • DOI 10.1046/j.1523-1755.2003.00712.x
    • A.I. Adler, R.J. Stevens, S.E. Manley, R.W. Bilous, C.A. Cull, and R.R. Holman Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64) Kidney Int 63 2003 225 232 (Pubitemid 35463925)
    • (2003) Kidney International , vol.63 , Issue.1 , pp. 225-232
    • Adler, A.I.1    Stevens, R.J.2    Manley, S.E.3    Bilous, R.W.4    Cull, C.A.5    Holman, R.R.6
  • 7
    • 78649811812 scopus 로고    scopus 로고
    • Proteinuria in diabetes: Bystander or pathway to cardiorenal disease?
    • J. Karalliedde, and G. Viberti Proteinuria in diabetes: bystander or pathway to cardiorenal disease? J Am Soc Nephrol 21 2010 2020 2027
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2020-2027
    • Karalliedde, J.1    Viberti, G.2
  • 8
    • 34250361947 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    • G. Wolf, and F.N. Ziyadeh Cellular and molecular mechanisms of proteinuria in diabetic nephropathy Nephron Physiol 106 2007 26 31
    • (2007) Nephron Physiol , vol.106 , pp. 26-31
    • Wolf, G.1    Ziyadeh, F.N.2
  • 9
    • 0346788786 scopus 로고    scopus 로고
    • The role of podocytes in glomerular pathobiology
    • DOI 10.1007/s10157-003-0259-6
    • K. Asanuma, and P. Mundel The role of podocytes in glomerular pathobiology Clin Exp Nephrol 7 2003 255 259 (Pubitemid 38031285)
    • (2003) Clinical and Experimental Nephrology , vol.7 , Issue.4 , pp. 255-259
    • Asanuma, K.1    Mundel, P.2
  • 10
    • 0035164681 scopus 로고    scopus 로고
    • The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death
    • H. Putaala, R. Soininen, and P. Kilpelainen The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death Hum Mol Genet 10 2001 1 8 (Pubitemid 32051561)
    • (2001) Human Molecular Genetics , vol.10 , Issue.1 , pp. 1-8
    • Putaala, H.1    Soininen, R.2    Kilpelainen, P.3    Wartiovaara, J.4    Tryggvason, K.5
  • 12
    • 34248377676 scopus 로고    scopus 로고
    • The endothelial glycocalyx: Composition, functions, and visualization
    • S. Reitsma, D.W. Slaaf, and H. Vink The endothelial glycocalyx: composition, functions, and visualization Pflugers Arch 454 2007 345 349
    • (2007) Pflugers Arch , vol.454 , pp. 345-349
    • Reitsma, S.1    Slaaf, D.W.2    Vink, H.3
  • 13
    • 35348904935 scopus 로고    scopus 로고
    • The structure and function of the endothelial glycocalyx layer
    • DOI 10.1146/annurev.bioeng.9.060906.151959
    • S. Weinbaum, J.M. Tarbell, and E.R. Damiano The structure and function of the endothelial glycocalyx layer Annu Rev Biomed Eng 9 2007 121 167 (Pubitemid 350246654)
    • (2007) Annual Review of Biomedical Engineering , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 14
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • DOI 10.1152/physrev.00055.2006
    • B. Haraldsson, J. Nystrom, and W.M. Deen Properties of the glomerular barrier and mechanisms of proteinuria Physiol Rev 88 2008 451 487 (Pubitemid 351522745)
    • (2008) Physiological Reviews , vol.88 , Issue.2 , pp. 451-487
    • Haraldsson, B.1    Nystrom, J.2    Deen, W.M.3
  • 15
    • 41849137193 scopus 로고    scopus 로고
    • What is the mechanism of microalbuminuria in diabetes: A role for the glomerular endothelium?
    • S.C. Satchell, and J.E. Tooke What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium? Diabetologia 51 2008 714 725
    • (2008) Diabetologia , vol.51 , pp. 714-725
    • Satchell, S.C.1    Tooke, J.E.2
  • 16
    • 0034989790 scopus 로고    scopus 로고
    • A gel-membrane model of glomerular charge and size selectivity in series
    • M. Ohlson, J. Sörensson, and B. Haraldsson A gel-membrane model of glomerular charge and size selectivity in series Am J Physiol Renal Physiol 280 2001 F396 F405
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Ohlson, M.1    Sörensson, J.2    Haraldsson, B.3
  • 18
    • 34547636295 scopus 로고    scopus 로고
    • Mechanical forces in diabetic kidney disease: A trigger for impaired glucose metabolism
    • DOI 10.1681/ASN.2006121362
    • L. Gnudi, S.M. Thomas, and G. Viberti Mechanical forces in diabetic kidney disease: a trigger for impaired glucose metabolism J Am Soc Nephrol 18 2007 2226 2232 (Pubitemid 47203836)
    • (2007) Journal of the American Society of Nephrology , vol.18 , Issue.8 , pp. 2226-2232
    • Gnudi, L.1    Thomas, S.M.2    Viberti, G.3
  • 20
    • 10644259663 scopus 로고    scopus 로고
    • From hyperglycemia to diabetic kidney disease: The role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines
    • DOI 10.1210/er.2003-0018
    • B.F. Schrijvers, A.S. De Vriese, and A. Flyvbjerg From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines Endocr Rev 25 2004 971 1010 (Pubitemid 39657775)
    • (2004) Endocrine Reviews , vol.25 , Issue.6 , pp. 971-1010
    • Schrijvers, B.F.1    De Vriese, A.S.2    Flyvbjerg, A.3
  • 21
    • 79955033725 scopus 로고    scopus 로고
    • A complex interplay of factors causes diabetic nephropathy
    • R.C. Stanton, and G.L. King A complex interplay of factors causes diabetic nephropathy Metabolism 60 2011 591 593
    • (2011) Metabolism , vol.60 , pp. 591-593
    • Stanton, R.C.1    King, G.L.2
  • 22
    • 84855245399 scopus 로고    scopus 로고
    • Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes
    • I.H. de Boer, W. Sun, and P.A. Cleary Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes N Engl J Med 365 2011 2366 2376
    • (2011) N Engl J Med , vol.365 , pp. 2366-2376
    • De Boer, I.H.1    Sun, W.2    Cleary, P.A.3
  • 23
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group BMJ 317 1998 703 713
    • (1998) BMJ , vol.317 , pp. 703-713
  • 24
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • DOI 10.1042/CS20040370
    • H. Takahashi, and M. Shibuya The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions Clin Sci 109 2005 227 241 (Pubitemid 41337127)
    • (2005) Clinical Science , vol.109 , Issue.3 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 26
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • N. Ferrara, H.P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat Med 9 2003 669 676 (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 27
    • 58149343883 scopus 로고    scopus 로고
    • Dei Cas A, et al. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice
    • C.H. Ku, and K.E. White Dei Cas A, et al. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice Diabetes 57 2008 2824 2833
    • (2008) Diabetes , vol.57 , pp. 2824-2833
    • Ku, C.H.1    White, K.E.2
  • 28
    • 77955870854 scopus 로고    scopus 로고
    • Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease
    • D. Veron, K.J. Reidy, and C. Bertuccio Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease Kidney Int 77 2010 989 999
    • (2010) Kidney Int , vol.77 , pp. 989-999
    • Veron, D.1    Reidy, K.J.2    Bertuccio, C.3
  • 29
    • 77957861954 scopus 로고    scopus 로고
    • Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
    • K. Sison, V. Eremina, and H. Baelde Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling J Am Soc Nephrol 21 2010 1691 1701
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1691-1701
    • Sison, K.1    Eremina, V.2    Baelde, H.3
  • 30
    • 0033840069 scopus 로고    scopus 로고
    • Coexpression of neuropilin-1, Flk1, and VEGF(164) in developing and mature mouse kidney glomeruli
    • B. Robert, X. Zhao, and D.R. Abrahamson Coexpression of neuropilin-1, Flk1, and VEGF(164) in developing and mature mouse kidney glomeruli Am J Physiol Renal Physiol 279 2000 F275 F282
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Robert, B.1    Zhao, X.2    Abrahamson, D.R.3
  • 32
    • 0030582384 scopus 로고    scopus 로고
    • Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
    • DOI 10.1006/bbrc.1996.1355
    • R.L. Kendall, G. Wang, and K.A. Thomas Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR Biochem Biophys Res Commun 226 1996 324 328 (Pubitemid 26331903)
    • (1996) Biochemical and Biophysical Research Communications , vol.226 , Issue.2 , pp. 324-328
    • Kendall, R.L.1    Wang, G.2    Thomas, K.A.3
  • 33
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: The key to anti-angiogenic therapeutics?
    • S.J. Harper, and D.O. Bates VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 8 2008 880 887
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 34
    • 56749179738 scopus 로고    scopus 로고
    • The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development
    • H.S. Bevan, N.M. van den Akker, and Y. Qiu The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development Nephron Physiol 110 2008 p57 p67
    • (2008) Nephron Physiol , vol.110
    • Bevan, H.S.1    Van Den Akker, N.M.2    Qiu, Y.3
  • 35
    • 0037631361 scopus 로고    scopus 로고
    • Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
    • DOI 10.1074/jbc.C300012200
    • H. Sugimoto, Y. Hamano, and D. Charytan Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria J Biol Chem 278 2003 12605 12608 (Pubitemid 36800018)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 12605-12608
    • Sugimoto, H.1    Hamanog, Y.2    Charytan, D.3    Cosgrove, D.4    Kieran, M.5    Sudhakar, A.6    Kalluri, R.7
  • 37
    • 34250374471 scopus 로고    scopus 로고
    • Role of the VEGF - A signaling pathway in the glomerulus: Evidence for crosstalk between components of the glomerular filtration barrier
    • V. Eremina, H.J. Baelde, and S.E. Quaggin Role of the VEGF - a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier Nephron Physiol 106 2007 32 37
    • (2007) Nephron Physiol , vol.106 , pp. 32-37
    • Eremina, V.1    Baelde, H.J.2    Quaggin, S.E.3
  • 40
    • 0038623780 scopus 로고    scopus 로고
    • Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    • R.R. Foster, R. Hole, and K. Anderson Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes Am J Physiol Renal Physiol 284 2003 F1263 F1273
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Foster, R.R.1    Hole, R.2    Anderson, K.3
  • 41
    • 81155123707 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes
    • C. Bertuccio, D. Veron, and P.K. Aggarwal Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes J Biol Chem 286 2011 39933 39944
    • (2011) J Biol Chem , vol.286 , pp. 39933-39944
    • Bertuccio, C.1    Veron, D.2    Aggarwal, P.K.3
  • 42
    • 1542349097 scopus 로고    scopus 로고
    • Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties
    • DOI 10.1097/01.ASN.0000115397.22519.03
    • S.C. Satchell, K.L. Anderson, and P.W. Mathieson Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties J Am Soc Nephrol 15 2004 566 574 (Pubitemid 38294786)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.3 , pp. 566-574
    • Satchell, S.C.1    Anderson, K.L.2    Mathieson, P.W.3
  • 43
    • 59949085812 scopus 로고    scopus 로고
    • Roles of angiopoietins in kidney development and disease
    • A.S. Woolf, L. Gnudi, and D.A. Long Roles of angiopoietins in kidney development and disease J Am Soc Nephrol 20 2009 239 244
    • (2009) J Am Soc Nephrol , vol.20 , pp. 239-244
    • Woolf, A.S.1    Gnudi, L.2    Long, D.A.3
  • 46
    • 33344477298 scopus 로고    scopus 로고
    • Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
    • DOI 10.1016/j.yexcr.2005.09.002, PII S0014482705004143
    • L. Eklund, and B.R. Olsen Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling Exp Cell Res 312 2006 630 641 (Pubitemid 43290339)
    • (2006) Experimental Cell Research , vol.312 , Issue.5 , pp. 630-641
    • Eklund, L.1    Olsen, B.R.2
  • 47
    • 79957880117 scopus 로고    scopus 로고
    • Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    • M. Jeansson, A. Gawlik, and G. Anderson Angiopoietin-1 is essential in mouse vasculature during development and in response to injury J Clin Invest 121 2011 2278 2289
    • (2011) J Clin Invest , vol.121 , pp. 2278-2289
    • Jeansson, M.1    Gawlik, A.2    Anderson, G.3
  • 48
    • 67649345892 scopus 로고    scopus 로고
    • Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
    • A.H. Salmon, C.R. Neal, and L.M. Sage Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx Cardiovasc Res 83 2009 24 33
    • (2009) Cardiovasc Res , vol.83 , pp. 24-33
    • Salmon, A.H.1    Neal, C.R.2    Sage, L.M.3
  • 49
    • 41149083878 scopus 로고    scopus 로고
    • Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity
    • A. Pozzi, G. Jarad, and G.W. Moeckel Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity Dev Biol 316 2008 288 301
    • (2008) Dev Biol , vol.316 , pp. 288-301
    • Pozzi, A.1    Jarad, G.2    Moeckel, G.W.3
  • 50
    • 0030851764 scopus 로고    scopus 로고
    • Signaling vascular morphogenesis and maintenance
    • DOI 10.1126/science.277.5322.48
    • D. Hanahan Signaling vascular morphogenesis and maintenance Science 277 1997 48 50 (Pubitemid 27450640)
    • (1997) Science , vol.277 , Issue.5322 , pp. 48-50
    • Hanahan, D.1
  • 53
    • 36348946298 scopus 로고    scopus 로고
    • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt-dependent pathway to modulate Tie2 signaling
    • DOI 10.1161/ATVBAHA.107.150482, PII 0004360520071200000020
    • C.M. Findley, M.J. Cudmore, and A. Ahmed VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling Arterioscler Thromb Vasc Biol 27 2007 2619 2626 (Pubitemid 350158914)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.12 , pp. 2619-2626
    • Findley, C.M.1    Cudmore, M.J.2    Ahmed, A.3    Kontos, C.D.4
  • 54
    • 65549129693 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases
    • H. Singh, C.S. Milner, and M.M. Aguilar Hernandez Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases Cell Signal 21 2009 1346 1350
    • (2009) Cell Signal , vol.21 , pp. 1346-1350
    • Singh, H.1    Milner, C.S.2    Aguilar Hernandez, M.M.3
  • 55
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • J. Gavard, V. Patel, and J.S. Gutkind Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia Dev Cell 14 2008 25 36
    • (2008) Dev Cell , vol.14 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 56
    • 12344330373 scopus 로고    scopus 로고
    • Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: Role of the renin-angiotensin system
    • DOI 10.1097/00004872-200501000-00026
    • B. Rizkalla, J.M. Forbes, and Z. Cao Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system J Hypertens 23 2005 153 164 (Pubitemid 40128994)
    • (2005) Journal of Hypertension , vol.23 , Issue.1 , pp. 153-164
    • Rizkalla, B.1    Forbes, J.M.2    Cao, Z.3    Boner, G.4    Cooper, M.E.5
  • 59
    • 0033007062 scopus 로고    scopus 로고
    • Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195
    • DOI 10.1007/s001250051198
    • K. Tsuchida, Z. Makita, and S. Yamagishi Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195 Diabetologia 42 1999 579 588 (Pubitemid 29196009)
    • (1999) Diabetologia , vol.42 , Issue.5 , pp. 579-588
    • Tsuchida, K.1    Makita, Z.2    Yamagishi, S.3    Atsumi, T.4    Miyoshi, H.5    Obara, S.6    Ishida, M.7    Ishikawa, S.8    Yasumura, K.9    Koike, T.10
  • 60
    • 0034046347 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in response to high glucose in rat mesangial cells
    • N.H. Kim, H.H. Jung, and D.R. Cha Expression of vascular endothelial growth factor in response to high glucose in rat mesangial cells J Endocrinol 165 2000 617 624 (Pubitemid 30407689)
    • (2000) Journal of Endocrinology , vol.165 , Issue.3 , pp. 617-624
    • Kim, N.H.1    Jung, H.H.2    Cha, D.R.3    Choi, D.S.4
  • 61
    • 79954632427 scopus 로고    scopus 로고
    • Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes
    • D. Veron, C.A. Bertuccio, and A. Marlier Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes Diabetologia 54 2011 1227 1241
    • (2011) Diabetologia , vol.54 , pp. 1227-1241
    • Veron, D.1    Bertuccio, C.A.2    Marlier, A.3
  • 63
    • 0036789207 scopus 로고    scopus 로고
    • Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody
    • A. Flyvbjerg, F. Dagnaes-Hansen, and A.S. De Vriese Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody Diabetes 51 2002 3090 3094
    • (2002) Diabetes , vol.51 , pp. 3090-3094
    • Flyvbjerg, A.1    Dagnaes-Hansen, F.2    De Vriese, A.S.3
  • 65
    • 0034091279 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy
    • P. Hovind, L. Tarnow, and P.B. Oestergaard Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy Kidney Int Suppl 75 2000 S56 S61
    • (2000) Kidney Int Suppl , vol.75
    • Hovind, P.1    Tarnow, L.2    Oestergaard, P.B.3
  • 66
    • 17044384530 scopus 로고    scopus 로고
    • Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: Relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis
    • H.S. Lim, G.Y. Lip, and A.D. Blann Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis Atherosclerosis 180 2005 113 118
    • (2005) Atherosclerosis , vol.180 , pp. 113-118
    • Lim, H.S.1    Lip, G.Y.2    Blann, A.D.3
  • 68
    • 3042739353 scopus 로고    scopus 로고
    • Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy
    • DOI 10.2337/diabetes.53.7.1831
    • Y. Yamamoto, Y. Maeshima, and H. Kitayama Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy Diabetes 53 2004 1831 1840 (Pubitemid 38857042)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1831-1840
    • Yamamoto, Y.1    Maeshima, Y.2    Kitayama, H.3    Kitamura, S.4    Takazawa, Y.5    Sugiyama, H.6    Yamasaki, Y.7    Makino, H.8
  • 69
    • 33947649573 scopus 로고    scopus 로고
    • Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy
    • H. Sun, J.M. Zheng, and S. Chen Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy Nephron Exp Nephrol 105 2007 e117 e123
    • (2007) Nephron Exp Nephrol , vol.105
    • Sun, H.1    Zheng, J.M.2    Chen, S.3
  • 70
    • 77955572754 scopus 로고    scopus 로고
    • Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro
    • X. Gao, H. Xu, and H. Liu Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro Biochem Biophys Res Commun 399 2010 31 36
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 31-36
    • Gao, X.1    Xu, H.2    Liu, H.3
  • 71
    • 78651252297 scopus 로고    scopus 로고
    • Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome
    • L.C. Clement, C. Avila-Casado, and C. Macé Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome Nat Med 17 2011 117 122
    • (2011) Nat Med , vol.17 , pp. 117-122
    • Clement, L.C.1    Avila-Casado, C.2    MacÉ, C.3
  • 72
    • 79954598744 scopus 로고    scopus 로고
    • Systemic and kidney toxicity of intraocular administration of vascular endothelial growth factor inhibitors
    • G. Pellé, N. Shweke, and J.P. Duong Van Huyen Systemic and kidney toxicity of intraocular administration of vascular endothelial growth factor inhibitors Am J Kidney Dis 57 2011 756 759
    • (2011) Am J Kidney Dis , vol.57 , pp. 756-759
    • Pellé, G.1    Shweke, N.2    Duong Van Huyen, J.P.3
  • 73
    • 79959804893 scopus 로고    scopus 로고
    • Endothelial factors and diabetic nephropathy
    • J. Karalliedde, and L. Gnudi Endothelial factors and diabetic nephropathy Diabetes Care 34 2011 S291 S296
    • (2011) Diabetes Care , vol.34
    • Karalliedde, J.1    Gnudi, L.2
  • 76
    • 67650236579 scopus 로고    scopus 로고
    • Abnormal angiogenesis in diabetic nephropathy
    • T. Nakagawa, T. Kosugi, and M. Haneda Abnormal angiogenesis in diabetic nephropathy. Diabetes 58 2009 1471 1478
    • (2009) Diabetes , vol.58 , pp. 1471-1478
    • Nakagawa, T.1    Kosugi, T.2    Haneda, M.3


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