A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models

Toxicological Sciences

Volumn 130, Issue 2, 2012, Pages 416-426

  Harrill, Alison H ^a,b   DeSmet, Kristina D ^a   Wolf, Kristina K ^b   Bridges, Arlene S ^c   Eaddy, J Scott ^a   Kurtz, C Lisa ^a   Hall, J Ed ^c   Paine, Mary F ^b   Tidwell, Richard R ^c   Watkins, Paul B ^a,b,c  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b University of North Carolina   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

DB289; Human African trypanosomiasis; Mouse diversity panel; Pharmacogenetic; Sleeping sickness

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA 2 MICROGLOBULIN; CREATININE; CYSTATIN C; KIDNEY INJURY MOLECULE 1; PAFURAMIDINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HISTOPATHOLOGY; KIDNEY INJURY; KIDNEY MASS; KIDNEY NECROSIS; LIPID TRANSPORT; LIPOGENESIS; LIVER INJURY; LIVER NECROSIS; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PHARMACOGENETICS; RAT; UREA NITROGEN BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDINES; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; CREATININE; DRUG-INDUCED LIVER INJURY; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; KIDNEY; KIDNEY DISEASES; MALE; MEMBRANE PROTEINS; MICE; RISK ASSESSMENT; SPECIES SPECIFICITY; TOXICITY TESTS; TRYPANOCIDAL AGENTS;

MUS; RODENTIA;

EID: 84869485008     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs238     Document Type: Article

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