A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: Evidence for catalytic difference between ACAT1 and ACAT2

FEBS Letters

Volumn 580, Issue 11, 2006, Pages 2741-2749

  An, Sojin ^a,b   Cho, Kyung Hyun ^c   Lee, Woo Song ^a   Lee, Jie Oh ^d   Paik, Young Ki ^b   Jeong, Tae Sook ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Yonsei University   (South Korea)

^c Yeungnam University   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Acyl CoA:cholesterol acyltransferase 1; Acyl CoA:cholesterol acyltransferase 2; Catalysis; Enzyme active site; Histidine; Point mutation

Indexed keywords

25 HYDROXYCHOLESTEROL; ACYL COA:CHOLESTEROL ACYLTRANSFERASE 1; ACYL COA:CHOLESTEROL ACYLTRANSFERASE 2; ALANINE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; HISTIDINE; ISOENZYME; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ACETYL-COA C-ACETYLTRANSFERASE; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CHOLESTEROL; CONSERVED SEQUENCE; ENZYME INHIBITORS; GENE EXPRESSION; HISTIDINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROL O-ACYLTRANSFERASE; SUBSTRATE SPECIFICITY;

EID: 33646178938     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.04.035     Document Type: Article

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