The contribution of physicochemical properties to multiple in vitro cytotoxicity endpoints

Toxicology in Vitro

Volumn 26, Issue 4, 2012, Pages 613-620

  Lu, Shuyan ^a   Jessen, Bart ^a   Strock, Christopher ^b   Will, Yvonne ^a  

^a PFIZER INC   (United States)

^b Apredica   (United States)

Author keywords

ClogP; High content screening; Multiple toxicity endpoints; PK a; TPSA

Indexed keywords

LIPID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CELL SCREENING; CONTROLLED STUDY; CYTOTOXICITY; DISSOCIATION CONSTANT; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; IMAGE ANALYSIS; IN VITRO STUDY; INNER CELL MASS; LIPOPHILICITY; LYSOSOME; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; MITOCHONDRION; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR SIZE; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; RAT; STEATOSIS;

1-OCTANOL; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DRUG DISCOVERY; DRUG TOXICITY; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHARMACEUTICAL PREPARATIONS; PHYSICOCHEMICAL PHENOMENA; RATS; WATER;

EID: 84859775987     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.01.025     Document Type: Article

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