A predictive nuclear translocation assay for spliced X-box-binding protein 1 identifies compounds with known organ toxicities

Assay and Drug Development Technologies

Volumn 9, Issue 1, 2011, Pages 79-87

  Hahmann, Christa ^a   Weiser, Amiee ^a   Duckett, Derek ^a   Schroeter, Thomas ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (N,N HEXAMETHYLENE)AMILORIDE; BETA GALACTOSIDASE; CALCIMYCIN; CYCLOSPORIN; IVERMECTIN; PODOPHYLLOTOXIN; SERTRALINE; SPIPERONE; THAPSIGARGIN; VINBLASTINE; X BOX BINDING PROTEIN 1;

ARTICLE; CELL FUNCTION; CLINICAL DECISION MAKING; CONTROLLED STUDY; DRUG TOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ASSAY; ENZYME FRAGMENT COMPLEMENTATION ASSAY; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; PROTEIN TRANSPORT; TOXICITY TESTING; VALIDATION PROCESS;

BIOLOGICAL ASSAY; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; HUMANS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TOXICITY TESTS; TRANSCRIPTION FACTORS;

EID: 79951712760     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2010.0300     Document Type: Article

References (46)

1. Yoshida H: ER stress and diseases. FEBS J 2007;274:630-658. (Pubitemid 46150855)
2. Kim I, Xu W, Reed JC: Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008;7:1013-1030.
3. Haze K, Yoshida H, Yanagi H, Yura T, Mori K: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 1999;10:3787-3799. (Pubitemid 29534025)
4. Harding HP, Zhang Y, Ron D: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999;397:271-274. (Pubitemid 29051178)
5. Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D: Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J 1998; 17:5708-5717. (Pubitemid 28445982)
6. Rao RV, Castro-Obregon S, Frankowski H, et al.: Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem 2002;277:21836-21842. (Pubitemid 34952336)
7. Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y: An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 2002;277: 34287-34294.
8. Lorz C, Justo P, Sanz A, Subira D, Egido J, Ortiz A: Paracetamol-induced renal tubular injury: a role for ER stress. J Am Soc Nephrol 2004;15:380-389. (Pubitemid 38140778)
9. Nagy G, Kardon T, Wunderlich L, et al.: Acetaminophen induces ER dependent signaling in mouse liver. Arch Biochem Biophys 2007;459:273-279. (Pubitemid 46389601)
10. Peyrou M, Hanna PE, Cribb AE: Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci 2007;99:346-353. (Pubitemid 47250391)
11. Pallet N, Bouvier N, Bendjallabah A, et al.: Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death. Am J Transplant 2008;8:2283-2296.
12. Han SW, Li C, Ahn KO, et al.: Prolonged endoplasmic reticulum stress induces apoptotic cell death in an experimental model of chronic cyclosporine nephropathy. Am J Nephrol 2008;28:707-714.
13. Liptak P, Ivanyi B: Primer: Histopathology of calcineurin-inhibitor toxicity in renal allografts. Nat Clin Pract Nephrol 2006;2:398-404; quiz following 404. (Pubitemid 44034190)
14. Kerkela R, Grazette L, Yacobi R, et al.: Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006;12:908-916. (Pubitemid 44175142)
15. Kramer JA, Sagartz JE, Morris DL: The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nat Rev Drug Discov 2007;6:636-649. (Pubitemid 47207750)
16. Hetz C, Glimcher LH: Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome. Mol Cell 11 2009;35:551-561.
17. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-891. (Pubitemid 34084979)
18. Lee K, Tirasophon W, Shen X, et al.: IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 2002;16:452-466. (Pubitemid 34165102)
19. Shen X, Ellis RE, Lee K, et al.: Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 2001;107:893-903. (Pubitemid 34084980)
20. Calfon M, Zeng H, Urano F, et al.: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002;415:92-96. (Pubitemid 34062456)
21. Lee AH, Iwakoshi NN, Glimcher LH: XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003;23:7448-7459. (Pubitemid 37271447)
22. Austin RC: The unfolded protein response in health and disease. Antioxid Redox Signal 2009;11:2279-2287.
23. Horecka J, Charter NW, Bosano BL, et al.: Antibody-free method for protein detection on blots using enzyme fragment complementation. Biotechniques 2006;40:381-383. (Pubitemid 46542629)
24. Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 1999;13:1211-1233. (Pubitemid 29250189)
25. Li M, Baumeister P, Roy B, et al.: ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol Cell Biol 2000;20:5096-5106. (Pubitemid 30431563)
26. Nakagawa T, Zhu H, Morishima N, et al.: Caspase-12 mediates endoplasmicreticulum- specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103. (Pubitemid 30038529)
27. Yamazaki M, Chiba K, Yoshikawa C: Genipin suppresses A23187-induced cytotoxicity in neuro2a cells. Biol Pharm Bull 2009;32:1043-1046.
28. Wang J, Yin Y, Hua H, et al.: Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response. J Cell Mol Med 2009;13:3888-3897.
29. Kim JW, Yang JH, Park HS, et al.: Rosiglitazone protects the pancreatic beta-cell death induced by cyclosporine A. Biochem Biophys Res Commun 2009;390: 763-768.
30. Bouvier N, Flinois JP, Gilleron J, et al.: Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death. Am J Physiol Renal Physiol 2009;296:F160-F169.
31. Ghosh TK, Bian JH, Short AD, Rybak SL, Gill DL: Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth. J Biol Chem 1991;266:24690-24697. (Pubitemid 21908997)
32. Crabtree GR: Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell 1999;96:611-614.
33. Lu D, Carson DA: Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol 2009;9:13.
34. Niles AL, Moravec RA, Riss TL: In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening. Curr Chem Genomics 2009;3:33-41.
35. Riss TL, Moravec RA: Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays. Assay Drug Dev Technol 2004;2:51-62. (Pubitemid 38647416)
36. Rao RV, Ellerby HM, Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 2004;11:372-380. (Pubitemid 38489415)
37. Park KS, Poburko D, Wollheim CB, Demaurex N: Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. Br J Pharmacol 2009;156:1296-1304.
38. Kim AJ, Shi Y, Austin RC, Werstuck GH: Valproate protects cells from ER stressinduced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci 2005;118(Pt 1):89-99. (Pubitemid 40277107)
39. Bilmen JG, Wootton LL, Michelangeli F: The inhibition of the sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase by macrocyclic lactones and cyclosporine A. Biochem J 2002;366(Pt 1):255-263. (Pubitemid 34971825)
40. Reddy KK, Lefkove B, Chen LB, et al.: The antidepressant sertraline downregulates Akt and has activity against melanoma cells. Pigment Cell Melanoma Res 2008;21:451-456. (Pubitemid 351990972)
41. Josephine A, Nithya K, Amudha G, Veena CK, Preetha SP, Varalakshmi P: Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats. BMC Pharmacol 2008;8:4.
42. Stacchiotti A, Bonomini F, Lavazza A, Rodella LF, Rezzani R: Adverse effects of cyclosporine A on HSP25, alpha B-crystallin and myofibrillar cytoskeleton in rat heart. Toxicology 2009;262:192-198.
43. Sioka C, Kyritsis AP: Central and peripheral nervous system toxicity of common chemotherapeutic agents. Cancer Chemother Pharmacol 2009;63: 761-767.
44. Rezzani R, Rodella LF, Fraschini F, et al.: Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage. J Pineal Res 2009;46:255-261.
45. Terkeltaub RA: Colchicine update: 2008. Semin Arthritis Rheum 2009;38: 411-419.
46. Jackson JR, Patrick DR, Dar MM, Huang PS: Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 2007;7:107-117. (Pubitemid 46160987)