Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Ay mice

Biochemical and Biophysical Research Communications

Volumn 428, Issue 2, 2012, Pages 315-320

  Takada, Mayumi ^a   Sumi, Mika ^b   Maeda, Ayumi ^a   Watanabe, Fumiko ^b   Kamiya, Toshikazu ^b   Ishii, Takeshi ^c   Nakano, Masahiko ^d   Akagawa, Mitsugu ^a  

^a Osaka Prefecture University   (Japan)

^b Kyowa Hakko Bio Co   (Japan)

^c UNIVERSITY OF SHIZUOKA   (Japan)

^d MITSUBISHI GAS CHEMICAL COMPANY INC   (Japan)

Author keywords

Diabetes; Insulin resistance; Insulin signal; Protein tyrosine phosphatase 1B; Pyrroloquinoline quinone

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; PYRROLOQUINOLINEQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN BLOOD LEVEL; MALE; MOUSE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT DURATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; MICE; MICE, INBRED STRAINS; MUSCLE FIBERS, SKELETAL; PQQ COFACTOR; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); MUS;

EID: 84869222944     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.10.055     Document Type: Article

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