p21-activated kinase-1 signaling regulates transcription of tissue factor and tissue factor pathway inhibitor

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 39291-39302

  Sánchez Solana, Beatriz ^a   Motwani, Mona ^a   Li, Da Qiang ^a   Eswaran, Jeyanthy ^a   Kumar, Rakesh ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD COAGULATION; CELL SURFACES; COAGULATION PROCESS; CRITICAL STEPS; EMBRYONIC DEVELOPMENT; MOUSE EMBRYONIC FIBROBLASTS; P-21 ACTIVATED KINASE; REGULATED GENES; TISSUE FACTOR PATHWAY INHIBITORS; TISSUE FACTORS; TRANSCRIPTIONAL REGULATION; WILD TYPES;

AMINO ACIDS; CELL CULTURE; COAGULATION; GENES; PHYSIOLOGY; TISSUE;

TRANSCRIPTION;

P21 ACTIVATED KINASE 1; PROTEIN C JUN; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; EMBRYO CELL; ENZYME ACTIVITY; FIBROBLAST; GENE CONTROL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HUMANS; LIPOPROTEINS; MICE; MICE, KNOCKOUT; P21-ACTIVATED KINASES; SIGNAL TRANSDUCTION; THROMBOPLASTIN;

EID: 84869210757     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.404061     Document Type: Article

References (54)

1. McVey, J. H. (1994) Tissue factor pathway. Bailliere's Clin. Haematol. 7, 469-484
2. Nemerson, Y. (1988) Tissue factor and hemostasis. Blood 71, 1-8
3. Versteeg, H. H., and Ruf, W. (2006) Emerging insights in tissue factor-dependent signaling events. Semin. Thromb. Hemostasis 32, 24-32
4. Bajaj, M. S., Birktoft, J. J., Steer, S. A., and Bajaj, S. P. (2001) Structure and biology of tissue factor pathway inhibitor. Thromb. Haemost. 86, 959-972 (Pubitemid 32975818)
5. Bugge, T. H., Xiao, Q., Kombrinck, K. W., Flick, M. J., Holmbäck, K., Danton, M. J., Colbert, M. C., Witte, D. P., Fujikawa, K., Davie, E. W., and Degen, J. L. (1996) Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl. Acad. Sci. U.S.A. 93, 6258-6263
6. Contrino, J., Hair, G., Kreutzer, D. L., and Rickles, F. R. (1996) In situ detection of tissue factor in vascular endothelial cells. Correlation with the malignant phenotype of human breast disease. Nat. Med. 2, 209-215 (Pubitemid 26054985)
7. Ruf, W. (2007) Tissue factor and PAR signaling in tumor progression. Thromb. Res. 120, S7-S12
8. Levi, M., ten Cate, H., Bauer, K. A., van der Poll, T., Edgington, T. S., Büller, H. R., van Deventer, S. J., Hack, C. E., ten Cate, J. W., and Rosenberg, R. D. (1994) Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J. Clin. Invest. 93, 114-120 (Pubitemid 24030827)
9. van der Poll, T., Büller, H. R., ten Cate, H., Wortel, C. H., Bauer, K. A., van Deventer, S. J., Hack, C. E., Sauerwein, H. P., Rosenberg, R. D., and ten Cate, J. W. (1990) Activation of coagulation after administration of tumor necrosis factor to normal subjects. N. Engl. J. Med. 322, 1622-1627 (Pubitemid 20171585)
10. Pendurthi, U. R., and Rao, L. V. (2002) Factor VIIa/tissue factor-induced signaling. A link between clotting and disease. Vitam. Horm. 64, 323-355
11. Manser, E., Leung, T., Salihuddin, H., Zhao, Z. S., and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46 (Pubitemid 24038530)
12. Tsakiridis, T., Taha, C., Grinstein, S., and Klip, A. (1996) Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase. J. Biol. Chem. 271, 19664-19667 (Pubitemid 26281699)
13. Molli, P. R., Li, D. Q., Murray, B. W., Rayala, S. K., and Kumar, R. (2009) PAK signaling in oncogenesis. Oncogene 28, 2545-2555
14. Vadlamudi, R. K., and Kumar, R. (2003) p21-activated kinases in human cancer. Cancer Metastasis Rev. 22, 385-393 (Pubitemid 36791894)
15. Barnes, C. J., Vadlamudi, R. K., Mishra, S. K., Jacobson, R. H., Li, F., and Kumar, R. (2003) Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat. Struct. Biol. 10, 622-628 (Pubitemid 36944715)
16. Bagrodia, S., Dérijard, B., Davis, R. J., and Cerione, R. A. (1995) Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27995-27998
17. Brown, J. L., Stowers, L., Baer, M., Trejo, J., Coughlin, S., and Chant, J. (1996) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6, 598-605 (Pubitemid 126656317)
18. Singh, R. R., Song, C., Yang, Z., and Kumar, R. (2005) Nuclear localization and chromatin targets of p21-activated kinase 1. J. Biol. Chem. 280, 18130-18137 (Pubitemid 41397965)
19. Li, F., Adam, L., Vadlamudi, R. K., Zhou, H., Sen, S., Chernoff, J., Mandal, M., and Kumar, R. (2002) p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep. 3, 767-773 (Pubitemid 34966016)
20. Balasenthil, S., Sahin, A. A., Barnes, C. J., Wang, R. A., Pestell, R. G., Vadlamudi, R. K., and Kumar, R. (2004) p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J. Biol. Chem. 279, 1422-1428 (Pubitemid 38082670)
21. Molli, P. R., Li, D. Q., Bagheri-Yarmand, R., Pakala, S. B., Katayama, H., Sen, S., Iyer, J., Chernoff, J., Tsai, M. Y., Nair, S. S., and Kumar, R. (2010) Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J. Cell Biol. 190, 101-114
22. Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M., and Chernoff, J. (1997) Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7, 202-210 (Pubitemid 27164726)
23. Vadlamudi, R. K., Li, F., Adam, L., Nguyen, D., Ohta, Y., Stossel, T. P., and Kumar, R. (2002) Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat. Cell Biol. 4, 681-690 (Pubitemid 34993704)
24. Li, D. Q., Pakala, S. B., Reddy, S. D., Ohshiro, K., Zhang, J. X., Wang, L., Zhang, Y., Moreno de Alborán, I., Pillai, M. R., Eswaran, J., and Kumar, R. (2011) Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis. Proc. Natl. Acad. Sci. U.S.A. 108, 8791-8796
25. Brown, P. H., Chen, T. K., and Birrer, M. J. (1994) Mechanism of action of a dominant-negative mutant of c-Jun. Oncogene 9, 791-799 (Pubitemid 24065917)
26. Li, D. Q., Pakala, S. B., Reddy, S. D., Ohshiro, K., Peng, S. H., Lian, Y., Fu, S. W., and Kumar, R. (2010) Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J. Biol. Chem. 285, 10044-10052
27. Kumar, R., Wang, R. A., Mazumdar, A., Talukder, A. H., Mandal, M., Yang, Z., Bagheri-Yarmand, R., Sahin, A., Hortobagyi, G., Adam, L., Barnes, C. J., and Vadlamudi, R. K. (2002) A naturally occurring MTA1 variant sequesters oestrogen receptor-α in the cytoplasm. Nature 418, 654-657
28. Schreiber, E., Matthias, P., Müller, M. M., and Schaffner, W. (1989) Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (Pubitemid 19198635)
29. Drake, T. A., Morrissey, J. H., and Edgington, T. S. (1989) Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am. J. Pathol. 134, 1087-1097 (Pubitemid 19142892)
30. Görlach, A., BelAiba, R. S., Hess, J., and Kietzmann, T. (2005) Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression. Thromb. Haemost. 93, 1168-1175
31. Rickles, F. R., and Levine, M. N. (2001) Epidemiology of thrombosis in cancer. Acta Haematol. 106, 6-12 (Pubitemid 32830510)
32. Kumar, R., Gururaj, A. E., and Barnes, C. J. (2006) p21-activated kinases in cancer. Nat. Rev. Cancer 6, 459-471
33. Ruf, W., Disse, J., Carneiro-Lobo, T. C., Yokota, N., and Schaffner, F. (2011) Tissue factor and cell signaling in cancer progression and thrombosis. J. Thromb. Haemost. 9, Suppl. 1, 306-315
34. Mackman, N., Fowler, B. J., Edgington, T. S., and Morrissey, J. H. (1990) Functional analysis of the human tissue factor promoter and induction by serum. Proc. Natl. Acad. Sci. U.S.A. 87, 2254-2258
35. Chong, C., Tan, L., Lim, L., and Manser, E. (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276, 17347-17353
36. Messeguer, X., Escudero, R., Farré, D., Núñez, O., Martínez, J., and Albà, M. M. (2002) PROMO. Detection of known transcription regulatory elements using species-tailored searches. Bioinformatics 18, 333-334 (Pubitemid 34183117)
37. Angus-Hill, M. L., Elbert, K. M., Hidalgo, J., and Capecchi, M. R. (2011) T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 108, 4914-4919
38. Zheng, R., and Blobel, G. A. (2010) GATA transcription factors and cancer. Genes Cancer 1, 1178-1188
39. Tanikawa, M., Wada-Hiraike, O., Nakagawa, S., Shirane, A., Hiraike, H., Koyama, S., Miyamoto, Y., Sone, K., Tsuruga, T., Nagasaka, K., Matsumoto, Y., Ikeda, Y., Shoji, K., Oda, K., Fukuhara, H., Nakagawa, K., Kato, S., Yano, T., and Taketani, Y. (2011) Multifunctional transcription factor TFII-I is an activator of BRCA1 function. Br. J. Cancer 104, 1349-1355
40. Soprano, D. R., Qin, P., and Soprano, K. J. (2004) Retinoic acid receptors and cancers. Annu. Rev. Nutr. 24, 201-221 (Pubitemid 38938791)
41. Khanna, A., Okkeri, J., Bilgen, T., Tiirikka, T., Vihinen, M., Visakorpi, T., and Westermarck, J. (2011) ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. PloS ONE 6, e17979
42. Shen, Q., Uray, I. P., Li, Y., Krisko, T. I., Strecker, T. E., Kim, H. T., and Brown, P. H. (2008) The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors. Oncogene 27, 366-377
43. Mackman, N. (1996) Regulation of tissue factor gene expression in human monocytic and endothelial cells. Haemostasis 26, 17-19
44. Bierhaus, A., Zhang, Y., Deng, Y., Mackman, N., Quehenberger, P., Haase, M., Luther, T., Müller, M., Böhrer, H., Greten, J., et al. (1995) Mechanism of the tumor necrosis factor α-mediated induction of endothelial tissue factor. J. Biol. Chem. 270, 26419-26432
45. Felts, S. J., Stoflet, E. S., Eggers, C. T., and Getz, M. J. (1995) Tissue factor gene transcription in serum-stimulated fibroblasts is mediated by recruitment of c-Fos into specific AP-1 DNA-binding complexes. Biochemistry 34, 12355-12362
46. Cui, M. Z., Parry, G. C., Edgington, T. S., and Mackman, N. (1994) Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate. Arterioscler. Thromb. 14, 807-814
47. Adam, L., Vadlamudi, R., Mandal, M., Chernoff, J., and Kumar, R. (2000) Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J. Biol. Chem. 275, 12041-12050 (Pubitemid 30237778)
48. Li, T., Zhang, J., Zhu, F., Wen, W., Zykova, T., Li, X., Liu, K., Peng, C., Ma, W., Shi, G., Dong, Z., and Bode, A. M. (2011) p21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at five threonine sites promotes cell transformation. Carcinogenesis 32, 659-666
49. Carson, S. D., and Archer, P. G. (1986) Tissue factor activity in HeLa cells measured with a continuous chromogenic assay and ELISA reader. Thromb. Res. 41, 185-195 (Pubitemid 16153360)
50. Carson, S. D. (1996) Manifestation of cryptic fibroblast tissue factor occurs at detergent concentrations that dissolve the plasma membrane. Blood Coagul. Fibrinolysis 7, 303-313
51. Bajaj, M. S., Steer, S., Kuppuswamy, M. N., Kisiel, W., and Bajaj, S. P. (1999) Synthesis and expression of tissue factor pathway inhibitor by serum-stimulated fibroblasts, vascular smooth muscle cells, and cardiac myocytes. Thromb. Haemost. 82, 1663-1672
52. Diebold, I., Petry, A., Djordjevic, T., Belaiba, R. S., Fineman, J., Black, S., Schreiber, C., Fratz, S., Hess, J., Kietzmann, T., and Görlach, A. (2010) Reciprocal regulation of Rac1 and PAK-1 by HIF-1α: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid. Redox Signal. 13, 399-412
53. Amirkhosravi, A., Meyer, T., Amaya, M., Davila, M., Mousa, S. A., Robson, T., and Francis, J. L. (2007) The role of tissue factor pathway inhibitor in tumor growth and metastasis. Semin. Thromb. Hemost. 33, 643-652 (Pubitemid 350157007)
54. Hembrough, T. A., Ruiz, J. F., Papathanassiu, A. E., Green, S. J., and Strickland, D. K. (2001) Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor. J. Biol. Chem. 276, 12241-12248