Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OS human osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 45, 2012, Pages 11395-11402

  Lin, Chin Chung ^a,b   Chuang, Ya Ju ^c   Yu, Chien Chih ^c   Yang, Jai Sing ^c   Lu, Chi Cheng ^d   Chiang, Jo Hua ^d   Lin, Jing Pin ^c   Tang, Nou Ying ^c   Huang, An Cheng ^e   Chung, Jing Gung ^c,f  

^a FENG YUAN HOSPITAL   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e St Mary's Medicine Nursing and Management College   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Apigenin; apoptosis; mitochondrial dysfunction; U 2 OS human osteosarcoma cells; xenograft tumor

Indexed keywords

ANTICANCER ACTIONS; ANTICANCER ACTIVITIES; ANTICANCER PROPERTIES; APIGENIN; APOPTOTIC CELLS; CASPASE-3; CELL APOPTOSIS; CELL VIABILITY; CHEMOTHERAPEUTIC AGENTS; CYTOSTATIC; CYTOTOXIC EFFECTS; HUMAN OSTEOSARCOMA; HUMAN OSTEOSARCOMA CELLS; IMMUNOBLOTTING; IN-VIVO; INDUCED APOPTOSIS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; NATURAL PRODUCTS; NOVEL INFORMATION; NUDE MICE; OSTEOSARCOMA; OSTEOSARCOMA CELLS; TUMOR GROWTH; VIABLE CELLS;

BIOLOGICAL MATERIALS; CELL DEATH; CYTOTOXICITY; FLOW CYTOMETRY; MITOCHONDRIA; TUMORS;

FLAVONOIDS;

ANTINEOPLASTIC AGENT; APIGENIN;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; BONE TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; HUMAN; MALE; METABOLISM; MITOCHONDRION; MOUSE; NUDE MOUSE; OSTEOSARCOMA; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APIGENIN; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; OSTEOSARCOMA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 84869200816     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf303446x     Document Type: Article

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