Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 543-556

  Marhadour, Sophie ^a   Marchand, Pascal ^a   Pagniez, Fabrice ^b   Bazin, Marc Antoine ^a   Picot, Carine ^a,b   Lozach, Olivier ^c   Ruchaud, Sandrine ^c   Antoine, Maud ^d   Meijer, Laurent ^e   Rachidi, Najma ^c,f   Le Pape, Patrice ^b  

^a UNIVERSITÉ DE NANTES   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c STATION BIOLOGIQUE   (France)

^d AtlanChim Pharma   (France)

^e Centre de Perharidy   (France)

^f INSTITUT PASTEUR   (France)

Author keywords

2,3 Diarylimidazo 1,2 a pyridines; Antileishmanial activity; Casein kinase 1; Direct arylation; Lipophilicity

Indexed keywords

2 (2 FLUOROPHENYL) 3 (PYRIDIN 3 YL)IMIDAZO(1,2 A)PYRIDINE; 2 (2 FLUOROPHENYL)3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (2 METHOXYPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (3 CHLOROPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (3,5 DICHLOROPHENYL) 3 (PYRIDIN 3 YL)IMIDAZO(1,2 A)PYRIDINE; 2 (3,5 DICHLOROPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (4 FLUOROPHENYL) 3 (3 NITROPHENYL)IMIDAZO(1,2 A)PYRIDINE; 2 (4 FLUOROPHENYL) 3 (PYRIDIN 3 YL)IMIDAZO(1,2 A)PYRIDINE; 2 (4 FLUOROPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (4 METHOXYPHENYL) 3 (3 NITROPHENYL)IMIDAZO(1,2 A)PYRIDINE; 2 (4 METHOXYPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 (4 NITROPHENYL) 3 PHENYLIMIDAZO(1,2 A)PYRIDINE; 2 PHENYL 3 (PYRIDIN 4 YL)IMIDAZO(1,2 A)PYRIDINE; 2 PHENYL 3 (PYRIDINE 3 YL)IMIDAZO(1,2 A)PYRIDINE; 2 PHENYL 3 (PYRIMIDIN 5 YL)IMIDAZO(1,2 A)PYRIDINE; 2 PHENYL 3 (THIOPHEN 3 YL)IMIDAZO(1,2 A)PYRIDINE; 2,3 DIPHENYLIMIDAZO(1,2 A)ALPYRIDINE; 3 (3,5 DICHLOROPHENYL) 2 PHENYLIMIDAZOL(1,2 A)PYRIDINE; 3 (4 METHOXYPHENYL) 2 PHENYLIMIDAZO(1,2 A)PYRIDINE; 3 (4 METHYLPHENYL) 2 PHENYLIMIDAZO(1,2 A)PYRIDINE; 3 (4 NITROPHENYL) 2 PHENYLIMIDAZO(1,2 A)PYRIDINE; 4 [2 PHENYLIMIDAZO(1,2 A)PYRIDIN 3 YL]BENZONITRILE; 4 [2 PHENYLIMIDAZO(1,2 A)PYRIDIN 3 YL]PHENYL 2,2 DIMETHYLPROPANOAE; 4 [2 PHENYLIMIDAZO(1,2 A)PYRIDINE 3 YL]PHENOL; ANTILEISHMANIAL AGENT; ETHYL 4 [2 PHENYLIMIDAZO(1,2 A)PYRIDIN 3 YL]BENZOATE; ETHYL 4 [3 PHENYLIMIDAZO(1,2 A)PYRIDIN 2 YL]BENZOATE; PENTAMIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; LEISHMANIA MAJOR; LIPOPHILICITY; PROMASTIGOTE;

ANTINEOPLASTIC AGENTS; ANTIPROTOZOAL AGENTS; CASEIN KINASE I; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; LEISHMANIA MAJOR; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869142101     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.048     Document Type: Article

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