Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1,3,4- thiadiazol-2-amines containing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moieties

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 124-128

  Tahghighi, Azar ^a   Razmi, Sepideh ^b   Mahdavi, Mohammad ^c   Foroumadi, Parham ^d   Ardestani, Sussan K ^b   Emami, Saeed ^e   Kobarfard, Farzad ^f   Dastmalchi, Siavoush ^a   Shafiee, Abbas ^c   Foroumadi, Alireza ^c,d  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,3,4 Thiadiazole; 1H 1,2,3 Triazole; 5 Nitrofuran; Antileishmanial activity

Indexed keywords

5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE DERIVATIVE; AMINE; ANTILEISHMANIAL AGENT; BENZYL DERIVATIVE; N ((1 (2 CHLORO 6 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (2,3 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (2,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (3 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (3,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N ((1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL) 5 (5 NITROFURAN 2 YL) 1,3,4 THIADIAZOL 2 AMINE; N [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLICK CHEMISTRY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; INFECTION; INFRARED SPECTROSCOPY; LEISHMANIA MAJOR; MACROPHAGE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTIPROTOZOAL AGENTS; CELLS, CULTURED; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGES, PERITONEAL; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRIAZOLES;

EID: 84858438686     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.046     Document Type: Article

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