Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4233-4237

  Jorda, Radek ^a   Sacerdoti Sierra, Nina ^b   Voller, Jiří ^a   Havlíček, Libor ^c   Kráčalíková, Kateřina ^c   Nowicki, Matthew W ^d   Nasereddin, Abedelmajeed ^e   Kryštof, Vladimír ^a   Strnad, Miroslav ^a   Walkinshaw, Malcolm D ^d   Jaffe, Charles L ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e HEBREW UNIVERSITY   (Israel)

Author keywords

Cyclin dependent kinase; Inhibitor; Leishmania; Therapy

Indexed keywords

2,6 DISUBSTITUTED PURINE; 3,7 DISUBSTITUTED PYRAZOLO[4,3 D]PYRIMIDINE; CYCLIN DEPENDENT KINASE 1; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTI LEISHMANIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL CYCLE REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; LEISHMANIA DONOVANI; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CDC2 PROTEIN KINASE; LEISHMANIA DONOVANI; PROTOZOAN PROTEINS; PURINES; PYRAZOLES; PYRIMIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 79959911608     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.076     Document Type: Article

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