Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells

European Journal of Pharmacology

Volumn 696, Issue 1-3, 2012, Pages 43-53

  Zhu, Hengrui ^a   Liu, Zulong ^a   Tang, Lisha ^a   Liu, Junhua ^b   Zhou, Mei ^a   Xie, Fang ^a   Wang, Zheng ^a   Wang, Yuqi ^a   Shen, Sida ^b   Hu, Lihong ^b   Yu, Long ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Gynostemma pentaphyllum; Gypenoside aglycon; KB VCR cells; Multidrug resistance (MDR); Multidrug resistance associated protein 1 (MRP1); P glycoprotein (P gp)

Indexed keywords

3BETA,20,21 TRIHYDROXYDAMMAR 24 ENE; 6 CARBOXYFLUORESCEIN; AGLYCONE; BREAST CANCER RESISTANCE PROTEIN; GYPENOSIDE; H 6; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; STAT3 PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOACCUMULATION; CANCER CELL; CELL FRACTIONATION; CELL PROLIFERATION; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; GYNOSTEMMA PENTAPHYLLUM; HUMAN; HUMAN CELL; MONOTHERAPY; MOUTH CANCER; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RNA TRANSCRIPTION; SHORT COURSE THERAPY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GYNOSTEMMA; HUMANS; MOUTH NEOPLASMS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; SAPOGENINS; VINCRISTINE;

EID: 84869094020     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.046     Document Type: Article

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