Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharide-stimulated microglial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 3, 2007, Pages 1237-1245

  Park, Jin Sun ^a   Woo, Moon Sook ^a   Kim, Dong Hyun ^c   Hyun, Jin Won ^d   Kim, Won Ki ^b   Lee, Jae Chul ^b   Kim, Hee Sun ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Jeju National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; ANTIINFLAMMATORY AGENT; CYTOKINE; DNA; DRUG METABOLITE; GLYCITEIN; GLYCITIN; GLYCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; IRISOLIDONE; ISOFLAVONE; KAKKALIDE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TECTORIGENIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA BINDING; DRUG EFFECT; DRUG INDICATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTESTINE FLORA; MICROGLIA; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN PROCESSING; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL SURVIVAL; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION; ISOFLAVONES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE II; PUERARIA; RIBONUCLEASES;

EID: 33847091290     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.114322     Document Type: Article

References (40)

1. Aldskogius H, Liu L, and Syensson M (1999) Glial responses to synaptic damage and plasticity. J Neurosci Res 58:33-41.
2. Bae EA, Han MJ, Lee KT, Choi JW, Park HJ, and Kim DH (1999) Metabolism of 6″-O-xylosyltectordin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities. Biol Pharm Bull 22:1314-1318.
3. Bang OY, Hong HS, Kim DH, Kim H, Boo JH, Huh K, and Mook-Jung I (2004) Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity. Neurobiol Dis 16:21-28.
4. Chan ED and Riches DW (2001) IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am J Physiol 280:1077-1083.
5. Cline JM and Hughes CL Jr (1998) Phytochemicals for the prevention of breast and endometrial cancer. Cancer Treat Res 94:107-134.
6. Doi M, Shichiri M, Katsuyama K, Marumo F, and Hirata Y (2000) Cytokine-activated p42/p44 MAP kinase is involved in inducible nitric oxide synthase gene expression independent from NF-kappa B activation in vascular smooth muscle cells. Hypertens Res 23:659-667.
7. Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, and Fontana A (1987) Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells. Eur J Immunol 17:1271-1278.
8. Gao HM, Liu B, Zhang W, and Hong JS (2003) Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J 17:1954-1956.
9. 15N] nitrate in biological fluids. Ann Biochem 126:131-138.
10. Han YO, Han MJ, Park SH, and Kim DH (2003) Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora. J Pharmacol Sci 93:331-336.
11. Hodgson JM, Croft KD, Puddey IB, Mori TA, and Beilin LJ (1996) Soybean isoflavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum. J Nutr Biochem 7:664-669.
12. Jiang B, Brecher P, and Cohen RA (2001) Persistent activation of nuclear factor-κB by interleukin-1β and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase. Arterioscler Thromb Vasc Biol 21:1915-1920.
13. Kan H, Xie Z, and Finkel MS (1999) TNF-alpha enhances cardiac myocyte NO production through MAP kinase-mediated NF-kappa B activation. Am J Physiol 277:H1641-H1646.
14. Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Kim SY, Kim HS, Kim DH, and Hyun JW (2005) Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide. Eur J Pharmacol 519:16-23.
15. Kim TJ (1996) Korean Resources Plants, Vol. 2, Seoul National University Press, Seoul, Korea.
16. Kim YP, Yamada M, Lim SS, Lee SH, Ryu N, Shin KH, and Ohuchi K (1999) Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochim Biophys Acta 1438:399-407.
17. Kim YS, Kim SS, Cho JJ, Choi DH, Hwang O, Shin DH, Chun HS, Beal MF, and Joh TH (2005) Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. J Neurosci 25:3701-3711.
18. Kopelovich L, Hawak ET, Lieberman R, Lawrence JA, Ali I, Viner JL, and Sigman CC (2000) Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 130:467S-471S.
19. Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
20. Lee KT, Sohn IC, Kim DH, Choi JW, Kwon SH, and Park HJ (2000) Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res (NY) 23:461-466.
21. Lee KT, Sohn IC, Kim YK, Choi JH, Choi JW, Park HJ, Itoh Y, and Miyamoto K (2001) Tectorigenin, an isoflavone of Pueraria thunbergiana BENTH., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull 24:1117-1121.
22. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, and Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21:8370-8377.
23. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, et al. (2000) Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 20:5709-5714.
24. McGeer PL, Itagaki S, Boyes BE, and McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291.
25. Pahl HL (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18:6853-6866.
26. Park HJ, Park JH, Moon JO, Lee KT, Jung WT, Oh SR, and Lee HK (1999) Isoflavone glycosides from the flowers of Pueraria thunbergiana. Phytochemistry 51:147-151.
27. Park JS, Woo MS, Kim SY, Kim WK, and Kim HS (2005) Repression of interferon-γ-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. J Neuroimmunol 168:56-64.
28. Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, et al. (2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25:8807-8814.
29. Sheu F, Lai HH, and Yen GC (2001) Suppression effect of soy isoflavones on nitric oxide production in RAW264.7 macrophages. J Agri Food Chem 49:1767-1772.
30. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, and Mullan MJ (2002) Role of CD40 ligand in amyloidosis in transgenic Alzheimer's disease. Nat Neurosci 5:1288-1293.
31. Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, and Mullan MJ (1999) Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science (Wash DC) 286:2352-2355.
32. Tortorella C, Stella I, Piazzolla G, Simone O, Cappiello V, and Antonaci S (2004) Role of defective ERK phosphorylation in the impaired GM-CSF-induced oxidative response of neutrophils in elderly humans. Mech Ageing Dev 125:539-546.
33. Town T, Nikolic V, and Tan J (2005) The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation 2:24-33.
34. Trieu VN and Uckun FM (1999) Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke. Biochem Biophys Res Commun 258:685-688.
35. Wang X, Chen S, Ma G, Ye M, and Lu G (2005) Genistein protects dopaminergic neurons by inhibiting microglial activation. Neuroreport 16:267-270.
36. Weber C, Negrescu E, Erl W, Pietsch A, Frankenberger M, Ziegler-Heitbrock HW, Siess W, and Webber PC (1995) Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. J Immunol 155:445-451.
37. Woo MS, Jang PG, Park JS, Kim WK, Joh TH, and Kim HS (2003) Selective modulation of lipopolysaccharide-stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cells. Mol Brain Res 113:86-96.
38. Wyss-Coray T (2006) Inflammation in Alzheimer's disease: driving force, bystander or beneficial response? Nat Med 12:1005-1015.
39. Wyss-Coray T and Mucke L (2002) Inflammation in neurodegenerative disease: a double-edged sword. Neuron 35:419-432.
40. Yamaki K, Kim DH, Ryu N, Kim YP, Shin KH, and Ohuchi K (2002) Effects of naturally occurring isoflavones on prostaglandin E2 production. Plant Med 68:97-100.