(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo

Leukemia

Volumn 26, Issue 3, 2012, Pages 451-460

  Dos Santos, G A S ^a   Abreu E Lima, R S ^a   Pestana, C R ^a   Lima, A S G ^a   Scheucher, P S ^a   Thome C H ^a   Gimenes Teixeira, H L ^a   Santana Lemos, B A A ^a   Lucena Araujo, A R ^a   Rodrigues, F P ^a   Nasr, R ^b,c   Uyemura, S A ^a   Falcao R P ^a   De The H ^c   Pandolfi, P P ^d   Curti, C ^a   Rego, E M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c CNRS   (France)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

tocopheryl succinate; acute promyelocytic leukemia; mitochondrial membrane potential; reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ARSENIC TRIOXIDE; CASPASE; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; RETINOIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TARGETING SIGNAL; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; RESPIRATORY CHAIN; TRANSGENIC MOUSE;

ALPHA-TOCOPHEROL; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; ARSENICALS; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEOPLASTIC STEM CELLS; ONCOGENE PROTEINS, FUSION; OXIDES; PROTEIN STABILITY; RATS; REACTIVE OXYGEN SPECIES; TRANSPLANTATION, ISOGENEIC; TRETINOIN;

EID: 84858001991     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.216     Document Type: Article

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