Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Zhao, Hong ^a   Li, Qinshan ^b   Wang, Jian ^a   Su, Xianwei ^c   Ng, Ka Man ^c   Qiu, Tian ^a   Shan, Ling ^a   Ling, Yun ^a   Wang, Linfang ^b   Cai, Jianqiang ^a   Ying, Jianming ^a  

^a CANCER HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYSTATHIONINE BETA SYNTHASE; K RAS PROTEIN; MESSENGER RNA; TRICHOSTATIN A;

ARTICLE; CANCER CELL; CANCER RECURRENCE; CANCER STAGING; CODON; COLORECTAL CANCER; CPG ISLAND; DEMETHYLATION; DIGESTIVE SYSTEM CANCER; DNA EXTRACTION; DNA METHYLATION; EPIGENETICS; EXON; FOLATE METABOLISM; GENE MUTATION; GENE SILENCING; METASTASIS; ONCOGENE K RAS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TUMOR SUPPRESSOR GENE;

CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYSTATHIONINE BETA-SYNTHASE; DNA METHYLATION; DOWN-REGULATION; FOLIC ACID; GASTROINTESTINAL NEOPLASMS; GENE SILENCING; HUMANS; MUTATION; NEOPLASM METASTASIS; NEOPLASM STAGING; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; STOMACH NEOPLASMS;

EID: 84869035342     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049683     Document Type: Article

References (41)

1. Crew KD, Neugut AI, (2006) Epidemiology of gastric cancer. World J Gastroenterol 12: 354-362.
2. Jemal A, Bray F, (2011) Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
3. Kinzler KW, Vogelstein B, (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
4. Jones PA, Baylin SB, (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428.
5. Esteller M, Risques RA, Toyota M, Capella G, Moreno V, et al. (2001) Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61: 4689-4692.
6. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95: 6870-6875.
7. Jin H, Wang X, Ying J, Wong AH, Cui Y, et al. (2007) Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A 104: 12353-12358.
8. Kim BN, Yamamoto H, Ikeda K, Damdinsuren B, Sugita Y, et al. (2005) Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues. Int J Oncol 26: 1217-1226.
9. Ying J, Li H, Seng TJ, Langford C, Srivastava G, et al. (2006) Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene 25: 1070-1080.
10. Ying J, Poon FF, Yu J, Geng H, Wong AH, et al. (2009) DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. Br J Cancer 100: 663-669.
11. Leung WK, Yu J, Ng EK, To KF, Ma PK, et al. (2001) Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues. Cancer 91: 2294-2301.
12. Bernal C, Aguayo F, Villarroel C, Vargas M, Díaz I, et al. (2008) Reprimo as a potential biomarker for early detection in gastric cancer. Clin Cancer Res 14: 6264-6269.
13. Bao L, Vlcek C, Paces V, Kraus JP, (1998) Identification and tissue distribution of human cystathionine beta-synthase mRNA isoforms. Arch Biochem Biophys 350: 95-103.
14. Kraus JP, Janosík M, Kozich V, Mandell R, Shih V, et al. (1999) Cystathionine beta-synthase mutations in homocystinuria. Hum Mutat 13: 362-375.
15. Ott N, Geddert H, Sarbia M, (2008) Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract. J Cancer Res Clin Oncol 134: 405-410.
16. Parl FF, (2005) Glutathione S-transferase genotypes and cancer risk. Cancer Lett 221: 123-129.
17. Paz MF, Avila S, Fraga MF, Pollan M, Capella G, et al. (2002) Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 62: 4519-4524.
18. Rosado JO, Salvador M, Bonatto D, (2007) Importance of the trans-sulfuration pathway in cancer prevention and promotion. Mol Cell Biochem 301: 1-12.
19. Shannon B, Gnanasampanthan S, Beilby J, Iacopetta B, (2002) A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50: 520-524.
20. Linnebank M, Schmidt S, Kölsch H, Linnebank A, Heun R, et al. (2004) The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma. Br J Cancer 90: 1969-1971.
21. Kim J, Hong SJ, Park JH, Park SY, Kim SW, et al. (2009) Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis. Oncol Rep 21: 1449-1454.
22. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416: 552-556.
23. Edge SE, B.D., Carducci MA, Compton CA (2010) AJCC Cancer Staging Manual. 7th Ed., New York: Springer.
24. Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, et al. (2005) The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 11: 6442-6449.
25. Dedeurwaerder S, Defrance M, Calonne E, Denis H, Sotiriou C, et al. (2011) Evaluation of the Infinium Methylation 450K technology. Epigenomics 3: 771-784.
26. Tao Q, Huang H, Geiman TM, Lim CY, Fu L, et al. (2002) Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum Mol Genet 11: 2091-2102.
27. Dutta S, Sinha S, Chattopadhyay A, Gangopadhyay PK, Mukhopadhyay J, et al. (2005) Cystathionine beta-synthase T833C/844INS68 polymorphism: a family-based study on mentally retarded children. Behav Brain Funct 1: 25.
28. Majors AK, Pyeritz RE, (2000) Pyeritz, A deficiency of cysteine impairs fibrillin-1 deposition: implications for the pathogenesis of cystathionine beta-synthase deficiency. Mol Genet Metab 70: 252-260.
29. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, et al. (2006) S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A 103: 6489-6494.
30. Demple B, Harrison L, (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 63: 915-948.
31. Laval J, (1996) Role of DNA repair enzymes in the cellular resistance to oxidative stress. Pathol Biol (Paris) 44: 14-24.
32. Audebert M, Salles B, Calsou P, (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 279: 55117-55126.
33. Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR, et al. (2002) B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control 13: 239-248.
34. Galbiatti AL, da Silva LM, Ruiz-Cintra MT, Raposo LS, Maníglia JV, et al. (2012) Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk. Eur J Cancer 48: 1525-1531.
35. Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, et al. (2010) Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 28: 466-474.
36. Fariña-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, et al. (2010) The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 21: 2396-2402.
37. Ahn JB, Chung WB, Maeda O, Shin SJ, Kim HS, et al. (2011) DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer 117: 1847-1854.
38. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, et al. (2001) Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer 85: 692-696.
39. Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, et al. (2010) Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell 18: 135-146.
40. Guerrero S, Casanova I, Farré L, Mazo A, Capellà G, et al. (2000) K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 60: 6750-6756.
41. Zlobec I, Bihl M, Foerster A, Rufle A, Lugli A, (2011) Comprehensive analysis of CpG island methylator phenotype (CIMP)-high,-low, and-negative colorectal cancers based on protein marker expression and molecular features. J Pathol 225: 336-343.