Expression of cystathionine β-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis

Oncology Reports

Volumn 21, Issue 6, 2009, Pages 1449-1454

  Kim, Jongmin ^a   Hong, Seok Joo ^a   Park, Jun Ho ^a   Park, Sun Young ^a   Kim, Seung Whan ^b   Cho, Eun Yoon ^c   Do, In Gu ^c   Joh, Jae Won ^c   Kim, Dae Shick ^c  

^a CbsBioscience Inc   (South Korea)

^b Chungnam National University College of Medicine   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Cystathionine synthase; Hepatocellular carcinoma; Prognosis; RT PCR

Indexed keywords

ALPHA FETOPROTEIN; CYSTATHIONINE BETA SYNTHASE; MESSENGER RNA; AFP PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VOLUME; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; LIVER RESECTION; LIVER TUMOR; MIDDLE AGED; MORTALITY; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; RISK FACTOR; TIME; TREATMENT OUTCOME;

ADULT; AGED; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CYSTATHIONINE BETA-SYNTHASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATECTOMY; HUMANS; KAPLAN-MEIERS ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 67650003378     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000373     Document Type: Article

References (31)

1. Bosch FX, Ribes J, Diaz M and Cleries R: Primary liver cancer: worldwide incidence and trends. Gastroenterology 127: S5-S16, 204.
2. Thorgeirsson SS and Grisham JW: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31: 339-346, 2002.
3. Llovet JM and Beaugrand M: Hepatocellular carcinoma: present status and future prospects. J Hepatol 38: S136-S149, 2003.
4. Kraus JP, Janoík M, Koich V, et al: Cystathionine β-synthase mutations in homocystinuria. Hum Mutat 13: 362-375, 1999.
5. Stipanuk MH: Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24: 539-577, 2004.
6. Jüngst C, Cheng B, Gehrke R, et al: Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatology 39: 1663-1672, 2004.
7. Avila MA, Berasain C, Torres L, et al: Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 33: 907-914, 2000.
8. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC and Banerjee R: S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity. Proc Natl Acad Sci USA 103: 6489-6494, 2006.
9. Edmondson H and Steiner P: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 7: 462-503, 1954.
10. Vandesompele J, Preter KD, Pattyn F, et al: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: Research0034, 2002.
11. Kinsell L, Harper H, Barton H, Michaels G and Weiss H: Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage. Science 106: 589-590, 1947.
12. Marchesini G, Bugianesi E, Bianchi G, et al: Defective methionine metabolism in cirrhosis: relation to severity of liver disease. Hepatology 16: 149-155, 1992.
13. Vendemiale G, Altomare E, Trizio T, et al: Effects of oral Sadenosyl- L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 24: 407-415, 1989.
14. Yang G, Cao K, Wu L and Wang R: Cystathionine γ-Lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J Biol Chem 279: 49199-49205, 2004.
15. Seshadri S, Beiser A, Selhub J, et al: Plasma homocysteine as a risk factor for dementia and Alzheimers disease. N Engl J Med 346: 476-483, 2002.
16. Mato JM, Alvarez L, Ortiz P and Pajares MA: S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Ther 73: 265-280, 1997.
17. Finkelstein JD: Methionine metabolism in mammals. J Nutr Biochem 1: 228-237, 1990.
18. Rosado JO, Salvador M and Bonatto D: Importance of the transsulfuration pathway in cancer prevention and promotion. Mol Cell Biochem 301: 1-12, 2007.
19. Mosharov E, Cranford MR and Banerjee R: The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry 39: 13005-13011, 200.
20. Demple B and Harrison L: Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 63: 915-948, 1994.
21. Laval J: Role of DNA repair enzymes in the cellular resistance to oxidative stress. Pathol Biol 44: 14-24, 1996.
22. Cerutti P and Trump B: Inflammation and oxidative stress in carcinogenesis. Cancer Cells 3: 1-7, 1991.
23. Audebert M, Salles B and Calsou P: Involvement of poly(ADPribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 279: 55117-55126, 2004.
24. Hoffman RM: Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis: a review and synthesis. Biochim Biophys Acta 738: 49-87, 1984.
25. Ott N, Geddert H and Sarbia M: Polymorphisms in methionine synthase (A2756G) and cystathionine β-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract. J Cancer Res Clin Oncol 134: 405-410, 2008.
26. Zhang W, Braun A, Bauman Z, Olteanu H, Madzelan P and Banerjee R: Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines. Cancer Res 65: 1554-1560, 2005.
27. Hansel DE, Rahman A, Hidalgo M, et al: Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol 163: 217-229, 2003.
28. Kimura F, Florl AR, Steinhoff C, et al: Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder. Mutat Res 458: 49-54, 2001.
29. Sharp L and Little J: Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159: 423-443, 2004.
30. Pufulete M, Al-Ghnaniem R, Leather AJM, et al: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124: 1240-1248, 2003.
31. Lissowska J, Gaudet MM, Brinton LA, et al: Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int J Cancer 120: 2696-2703, 2007.