Epigenetic changes during cell transformation

Advances in Experimental Medicine and Biology

Volumn 754, Issue , 2013, Pages 179-194

  Futscher, Bernard W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; TOXIN;

ARTICLE; CANCER THERAPY; CARCINOGENESIS; CELL IMMORTALIZATION; CELL PROLIFERATION; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENETICS; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; STRESS; TELOMERE;

EID: 84869028723     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-9967-2_9     Document Type: Article

References (65)

1. Clark SJ et al (1994) High sensitivity mapping of methylated cytosines. Nucleic Acids Res 22(15):2990-2997 (Pubitemid 24260626)
2. Frommer M et al (1992) A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 89(5):1827-1831
3. Lister R et al (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271):315-322
4. Maunakea AK et al (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466(7303):253-257
5. Drew Y et al (2011) Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. J Natl Cancer Inst 103(4):334-346
6. Hegi ME et al (2005) MGMT gene silencing and bene fi t from temozolomide in glioblastoma. N Engl J Med 352(10):997-1003 (Pubitemid 40349502)
7. Lorenzi PL et al (2009) DNA fi ngerprinting of the NCI-60 cell line panel. Mol Cancer Ther 8(4):713-724
8. Nims RW et al (2010) Short tandem repeat pro fi ling: part of an overall strategy for reducing the frequency of cell misidenti fi cation. In Vitro Cell Dev Biol Anim 46(10):811-819
9. Hammond SL, Ham RG, Stampfer MR (1984) Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc Natl Acad Sci USA 81(17):5435-5439 (Pubitemid 14048762)
10. Amstad P et al (1988) Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras. Mol Carcinog 1(3):151-160 (Pubitemid 19076918)
11. Boukamp P et al (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106(3):761-771 (Pubitemid 18089976)
12. Ke Y et al (1988) Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation; research in biological diversity 38(1):60-66
13. Miller FR et al (1993) Xenograft model of progressive human proliferative breast disease. J Natl Cancer Inst 85(21):1725-1732 (Pubitemid 23320842)
14. Petzoldt JL et al (1995) Immortalisation of human urothelial cells. Urol Res 23(6):377-380 (Pubitemid 26015191)
15. Bello D et al (1997) Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis 18(6):1215-1223 (Pubitemid 28132513)
16. Kiyono T et al (1998) Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396(6706):84-88 (Pubitemid 28520454)
17. Dickson MA et al (2000) Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 20(4):1436-1447 (Pubitemid 30069263)
18. Chapman E et al (2006) Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway. Oncogene 25(36):5037-5045
19. Chang CJ et al (2011) p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 13(3):317-323
20. Junk DJ et al (2008) Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells. Neoplasia 10(5):450-461 (Pubitemid 351657387)
21. Vrba L et al (2008) p53 induces distinct epigenetic states at its direct target promoters. BMC Genomics 9:486
22. Vahidnia A, van der Voet G, de Wolff F (2007) Arsenic neurotoxicity - a review. Hum Exp Toxicol 10:823-832 (Pubitemid 350221398)
23. Rohe G (1896) Arsenic. In: Foster F (ed) Reference-book of practical therapeutics. D. Appleton, New York, p 142
24. Emadi A, Gore SD (2010) Arsenic trioxide - an old drug rediscovered. Blood Rev 24(4-5):191-199
25. Wu D et al (2010) Antitumor effect and mechanisms of arsenic trioxide on subcutaneously implanted human gastric cancer in nude mice. Cancer Genet Cytogenet 2:90-96
26. Yeh K et al (2011) Tumor growth inhibition of metastatic nasopharyngeal carcinoma cell lines by low dose of arsenic trioxide via alteration of cell cycle progression and induction of apoptosis. Head Neck 5:734-742
27. Chen C et al (2007) Arsenic and diabetes and hypertension in human populations: a review. Toxicol Appl Pharmacol 3:298-304 (Pubitemid 47198278)
28. Grandjean P, Murata K (2007) Developmental arsenic neurotoxicity in retrospect. Epidemiology 1:25-26 (Pubitemid 46019617)
29. Smith A et al (1998) Marked increase in bladder and lung cancer mortality in a region of northern Chile due to arsenic in drinking water. Am J Epidemiol 7:660-669 (Pubitemid 28180309)
30. Vahter M (2008) Health effects of early life exposure to arsenic. Basic Clin Pharmacol Toxicol 2:204-211 (Pubitemid 351143425)
31. Chen C et al (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br J Cancer 5:888-892
32. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004) Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr Eval Carcinog Risks Hum 84:1-477
33. Rossman TG et al (1980) Absence of arsenite mutagenicity in E. coli and Chinese hamster cells. Environ Mutagen 2(3):371-379 (Pubitemid 12118159)
34. Zhao C et al (1997) Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci USA 20:10907-10912 (Pubitemid 27430834)
35. Achanzar W et al (2002) Inorganic arsenite-induced malignant transformation of human prostate epithelial cells. J Natl Cancer Inst 24:1888-1891 (Pubitemid 36104634)
36. Bredfeldt T et al (2006) Monomethylarsonous acid induces transformation of human bladder cells. Toxicol Appl Pharmacol 1:69-79 (Pubitemid 44402634)
37. Chang Q et al (2010) Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res 70(12):5127-5135
38. Pi J et al (2008) Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med 45(5):651-658
39. Sens D et al (2004) Inorganic cadmium- and arsenite-induced malignant transformation of human bladder urothelial cells. Toxicol Sc 1:56-63 (Pubitemid 38660248)
40. Dinney CP et al (2004) Focus on bladder cancer. Cancer Cell 6(2):111-116 (Pubitemid 39485683)
41. Nishiyama H et al (2001) Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. Oncogene 23:2956-2964 (Pubitemid 33027763)
42. Jensen TJ et al (2009) Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells. Toxicol Appl Pharmacol 241(2):221-229
43. Frigola J et al (2006) Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 38(5):540-549
44. Novak P et al (2006) Epigenetic inactivation of the HOXA gene cluster in breast cancer. Cancer Res 66(22):10664-10670 (Pubitemid 44876960)
45. Rauch T et al (2007) Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci USA 104(13):5527-5532 (Pubitemid 47175714)
46. Stransky N et al (2006) Regional copy number-independent deregulation of transcription in cancer. Nat Genet 38(12):1386-1396 (Pubitemid 44837560)
47. Benbrahim-Tallaa L et al (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol 3:288-298 (Pubitemid 41020671)
48. Coppin J, Qu W, Waalkes M (2008) Interplay between cellular methyl metabolism and adaptive ef fl ux during oncogenic transformation from chronic arsenic exposure in human cells. J Biol Chem 28:19342-19350
49. Garbe JC et al (2007) Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. Cell Cycle 6(15):1927-1936 (Pubitemid 47327912)
50. Stampfer MR, Bartley JC (1985) Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc Natl Acad Sci USA 82(8):2394-2398 (Pubitemid 15064494)
51. Chin K et al (2004) In situ analyses of genome instability in breast cancer. Nat Genet 36(9):984-988 (Pubitemid 39167495)
52. Holst CR et al (2003) Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 63(7):1596-1601 (Pubitemid 36373649)
53. Li Y et al (2007) Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Mol Cancer 6:7
54. Brenner AJ, Stampfer MR, Aldaz CM (1998) Increased p16 expression with fi rst senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene 17(2):199-205 (Pubitemid 28371893)
55. Geradts J, Wilson PA (1996) High frequency of aberrant p16(INK4A) expression in human breast cancer. Am J Pathol 149(1):15-20 (Pubitemid 26230973)
56. Romanov SR et al (2001) Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409(6820):633-637 (Pubitemid 32154817)
57. Nonet GH et al (2001) The ZNF217 gene ampli fi ed in breast cancers promotes immortalization of human mammary epithelial cells. Cancer Res 61(4):1250-1254 (Pubitemid 34292535)
58. Stampfer MR et al (2001) Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A human mammary epithelial cells. Proc Natl Acad Sci USA 98(8):4498-4503 (Pubitemid 32295005)
59. Clark R et al (1988) Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Res 48(16):4689-4694
60. Olsen CL et al (2002) Raf-1-induced growth arrest in human mammary epithelial cells is p16- independent and is overcome in immortal cells during conversion. Oncogene 21(41): 6328-6339
61. Stampfer MR, Yaswen P (2003) Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett 194(2):199-208 (Pubitemid 36577331)
62. Novak P et al (2009) Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res 69(12):5251-5258
63. Ehrich M et al (2005) Quantitative high-throughput analysis of DNA methylation patterns by base-speci fi c cleavage and mass spectrometry. Proc Natl Acad Sci USA 102(44): 15785-15790 (Pubitemid 41552820)
64. Coolen MW et al (2010) Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol 12(3):235-246
65. Walen KH, Stampfer MR (1989) Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality. Cancer Genet Cytogenet 37(2):249-261 (Pubitemid 19101226)