Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Ke, Wei ^a   Pattanaik, Priyaranjan ^a   Bethel, Christopher R ^c   Sheri, Anjaneyulu ^d   Buynak, John D ^d   Bonomo, Robert A ^b,c   van den Akker, Focco ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE SHV; BETA LACTAMASE SHV 1; CARBONYL DERIVATIVE; ENZYME INHIBITOR; LN 1 255; PENEM DERIVATIVE; PIPERACILLIN; SA 1 204; SA 3 53; TAZOBACTAM; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; CYCLIZATION; DEACYLATION; DRUG CONFORMATION; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; ELECTRON DENSITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; NONHUMAN; TORSION ANGLE;

BETA-LACTAMASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; KINETICS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIENAMYCINS;

BACTERIA (MICROORGANISMS);

EID: 84869021254     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049035     Document Type: Article

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