Identification and characterization of a kunzeaol synthase from Thapsia garganica: Implications for the biosynthesis of the pharmaceutical thapsigargin

Biochemical Journal

Volumn 448, Issue 2, 2012, Pages 261-271

  Pickel, Benjamin ^a   Drew, Damian P ^b   Manczak, Tom ^b   Weitzel, Corinna ^b   Simonsen, Henrik T ^b   Ro, Dae Kyun ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

6 Hydroxygermacra 1(10),4 diene; Genomics; Kunzeaol; Sesquiterpene synthase; Thapsia garganica; Thapsigargin

Indexed keywords

1,6 GERMACRADIEN 5 OL; 6BETA HYDROXYGERMACRA 1(10),4 DIENE; ALPHA CADINOL; BICYCLOGERMACRENE; DELTA CADINENE; FARNESYL DIPHOSPHATE; FUNGAL EXTRACT; GERMACRENE D; NEROLIDOL; RECOMBINANT ENZYME; SESQUITERPENOID; SYNTHETASE; TAU MUUROLOL; TERPENE SYNTHASE 1; TERPENE SYNTHASE 2; TERPENOID; THAPSIGARGIN; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; FUNGUS CULTURE; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; METABOLIC ENGINEERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PH; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; THAPSIA; THAPSIA GARGANICA; YEAST;

ALKYL AND ARYL TRANSFERASES; DNA, PLANT; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION; GENES, PLANT; KINETICS; MODELS, BIOLOGICAL; PLANT PROTEINS; PLANT ROOTS; RECOMBINANT PROTEINS; SESQUITERPENES; THAPSIA; THAPSIGARGIN;

THAPSIA GARGANICA;

EID: 84869013124     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120654     Document Type: Article

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