Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 47, Issue 11, 2012, Pages 1420-1428

  Parson, Whitney B ^a   Koeniger, Stormy L ^b   Johnson, Robert W ^b   Erickson, Jamie ^b   Tian, Yu ^b   Stedman, Christopher ^b   Schwartz, Annette ^b   Tarcsa, Edit ^b   Cole, Roderic ^b   Van Berkel, Gary J ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

chloroquine; imaging; LESA; mass spectrometry; surface sampling; tissue analysis

Indexed keywords

ANALYTICAL METHOD; ANIMAL TISSUE; CHLOROQUINE; DIRECT ANALYSIS; DRUG DISCOVERY PROCESS; FLUORESCENT DETECTION; LESA; LIQUID EXTRACTION; MINIMAL SAMPLE; PHARMACEUTICAL COMPOUNDS; SPATIALLY RESOLVED; SURFACE SAMPLING; TANDEM MASS SPECTROMETRY; TARGET TISSUES; TISSUE ANALYSIS; TISSUE DISTRIBUTIONS; TISSUE SECTIONS; WHOLE-BODY;

IMAGING TECHNIQUES; MASS SPECTROMETRY; METABOLITES; SURFACE ANALYSIS;

TISSUE;

CHLOROQUINE;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ISOLATION; DRUG METABOLISM; DRUG PENETRATION; DRUG TISSUE LEVEL; LIQUID EXTRACTION SURFACE ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TISSUE SECTION;

ANIMALS; CHEMICAL FRACTIONATION; CHLOROQUINE; HISTOLOGICAL TECHNIQUES; LIVER; LUNG; MALE; MOLECULAR IMAGING; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 84869009503     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3068     Document Type: Article

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