Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of actaea racemosa

ACS Chemical Neuroscience

Volumn 3, Issue 11, 2012, Pages 941-951

  Findeis, Mark A ^a,g   Schroeder, Frank ^b   McKee, Timothy D ^a   Yager, Debra ^c   Fraering, Patrick C ^d   Creaser, Steffen P ^a   Austin, Wesley F ^a   Clardy, Jon ^e   Wang, Rong ^f   Selkoe, Dennis ^d   Eckman, Christopher B ^c  

^a Satori Pharmaceuticals Incorporated   (United States)

^b United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^c MAYO CLINIC   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g Resilientx Therapeutics   (United States)

Author keywords

Actaea racemosa; Alzheimers disease; amyloid beta peptide; botanical extract; gamma secretase modulator; triterpene glycoside

Indexed keywords

24 O ACETYLHYDROSHENGMANOL (DELTA 16,17) ENOL ETHER 3 O BETA XYLOPYRANOSIDE; AMYLOID BETA PROTEIN[1-42]; CIMICIFUGA RACEMOSA EXTRACT; GAMMA SECRETASE INHIBITOR; UNCLASSIFIED DRUG;

ACTAEA RACEMOSA; ALZHEIMER DISEASE; ARTICLE; BIOASSAY; CELL CULTURE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SYNTHESIS; FRACTIONATION; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; CIMICIFUGA; GLYCOSIDES; MICE; PLANT EXTRACTS; PLANT ROOTS; RHIZOME; TRITERPENES;

CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA; MUS;

EID: 84868690878     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3000857     Document Type: Article

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