Natural product extracts that reduce accumulation of the alzheimer's amyloid β peptide: Selective reduction in aβ42

Journal of Molecular Neuroscience

Volumn 19, Issue 1-2, 2002, Pages 129-133

  Yager, Debra ^a   Watson, Mona ^a   Healy, Brent ^a   Eckman, Elizabeth A ^a   Eckman, Christopher B ^a  

^a MAYO CLINIC   (United States)

Author keywords

Alzheimers; Amyloid; A ; Cell based; HTS; Natural products

Indexed keywords

AMYLOID BETA PROTEIN; NATURAL PRODUCT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CELL SCREENING; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN CONTENT;

ANIMALIA;

EID: 0036676693     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-002-0023-5     Document Type: Article

References (10)

1. Inflammation and Alzheimer's disease
2. Functional gammasecretase inhibitors reduce beta-amyloid peptide levels in brain
3. Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
4. Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidylinositol kinase inhibitor wortmannin
5. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid β peptide (Aβ)
6. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
7. The toxicity in vitro of beta-amyloid protein
8. Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
9. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
10. Mechanisms of neuronal degeneration in Alzheimer's disease