High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 5, 2012, Pages 941-951

  Fallarero, Adyary ^a   Pohjanoksa, Katariina ^b   Wissel, Gloria ^c   Parkkisenniemi Kinnunen, Ulla Mari ^a   Xhaard, Henri ^c   Scheinin, Mika ^b   Vuorela, Pia ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

2 Adrenoceptors; 2 , 2 Bisepigallocatechin digallate; Chemical libraries; GPCR; Lysergol; Partial agonist

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOMATION; BINDING AFFINITY; FOLLOW UP; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; NONHUMAN; PRIORITY JOURNAL; SIGNAL NOISE RATIO;

ADRENERGIC AGONISTS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 84868689881     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.08.021     Document Type: Article

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