Conserved structural, pharmacological and functional properties among the three human and five zebrafish α 2-adrenoceptors

British Journal of Pharmacology

Volumn 144, Issue 2, 2005, Pages 165-177

  Ruuskanen, Jori O ^a   Laurila, Jonne ^a   Xhaard, Henri ^b   Rantanen, Ville Veikko ^a,b   Vuoriluoto, Karoliina ^a   Wurster, Siegfried ^c   Marjamäki, Anne ^a,d   Vainio, Minna ^a   Johnson, Mark S ^b   Scheinin, Mika ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c Oy Juvantia Pharma Ltd   (Finland)

^d Biotie Therapies Corp   (Finland)

Author keywords

2 Adrenergic receptor; Adrenoceptor; Catecholamine; GPCR; Ligand binding; Molecular evolution; Molecular modelling; Monoamine receptor; Protein structure; Zebrafish

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 12 ETHYLSULFONYL 5,8,8A,9,10,11,12,12A,13,13A DECAHYDRO 3 METHOXY 6H ISOQUINO[2,1 G][1,6]NAPHTHYRIDINE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ALPHA 2D ADRENERGIC RECEPTOR; ALPHA 2DA ADRENERGIC RECEPTOR; ALPHA 2DB ADRENERGIC RECEPTOR; ATIPAMEZOLE; BRIMONIDINE; CHLORPROMAZINE; CLONIDINE; CLOZAPINE; DEXMEDETOMIDINE; G PROTEIN COUPLED RECEPTOR KINASE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYGROMYCIN B; IDAZOXAN; OXYMETAZOLINE; PERTUSSIS TOXIN; PRAZOSIN; RAUWOLSCINE; RECEPTOR SUBTYPE; SPIPERONE; SPIROXATRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WB 410;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CHO CELL; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR DENSITY; ZEBRA FISH;

ANIMALS; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, ALPHA-2; ZEBRAFISH;

EID: 20844441768     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706057     Document Type: Article

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