Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection

Cell Cycle

Volumn 10, Issue 23, 2011, Pages 4065-4073

  Balliet, Renee M ^a   Capparelli, Claudia ^a   Guido, Carmela ^a   Pestell, Timothy G ^a   Martinez Outschoorn, Ubaldo E ^a   Lin, Zhao ^a   Whitaker Menezes, Diana ^a   Chiavarina, Barbara ^a   Pestell, Richard G ^a   Howell, Anthony ^b   Sotgia, Federica ^a,b   Lisanti, Michael P ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aerobic glycolysis; Aging; Cancer associated fibroblasts; Cancer metabolism; Caveolin 1; Electron transport; Hydrogen peroxide; Lactate; Mitochondria; Oxidative phosphorylation (OXPHOS); Respiratory chain; Reverse Warburg effect; TFAM

Indexed keywords

BIOLOGICAL MARKER; CAVEOLIN 1; HYDROGEN PEROXIDE; LACTIC ACID; MITOCHONDRIAL TRANSCRIPTION FACTOR A; TRANSFER RNA;

ANAEROBIC GLYCOLYSIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER ASSOCIATED FIBROBLAST; CANCER PATIENT; CELL AGING; COCULTURE; CONTROLLED STUDY; ENZYME SYNTHESIS; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR RECURRENCE; TUMOR XENOGRAFT;

EID: 82855170859     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.23.18254     Document Type: Article

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