Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor

Molecular and Cellular Biochemistry

Volumn 371, Issue 1-2, 2012, Pages 89-96

  Lominadze, David ^a   Tyagi, Neetu ^a   Sen, Utpal ^a   Ovechkin, Alexander ^a   Tyagi, Suresh C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Alzheimer's disease; CBS; Mitochondria; Muscimol; Pial venules; ROS; Stroke; Vascular dementia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALBUMIN; COLLAGENASE 3; CYSTATHIONINE BETA SYNTHASE; GELATINASE A; GELATINASE B; HOMOCYSTEINE; MATRIX METALLOPROTEINASE; MESSENGER RNA; OXIDOREDUCTASE; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOREDOXIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ALLELE; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN CORTEX; CONTROLLED STUDY; ENZYME ACTIVITY; EXCITOTOXICITY; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; MICROVASCULARIZATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PERMEABILITY; PROTEIN ANALYSIS; REDOX STRESS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CEREBROVASCULAR CIRCULATION; CYSTATHIONINE BETA-SYNTHASE; GABA-A RECEPTOR AGONISTS; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MATRIX METALLOPROTEINASES; MICE; MICE, TRANSGENIC; MUSCIMOL; RECEPTORS, GABA-A; TISSUE INHIBITOR OF METALLOPROTEINASES;

MUS; MUS MUSCULUS;

EID: 84868589696     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1425-5     Document Type: Article

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