1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandin E2 production

Pharmacological Research

Volumn 43, Issue 5, 2001, Pages 445-451

  Fruscella, Paolo ^a   Sottocorno, Marcello ^a   Di Braccio, Mario ^b   Diomede, Luisa ^a   Piccardi, Nicola ^a   Cagnotto, Alfredo ^a   Grossi, Giancarlo ^b   Romano, Maria ^a   Mennini, Tiziana ^a   Roma, Giorgio ^b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

IL 6; Inflammation; PGE2; Triazolo benzodiazepine

Indexed keywords

1 METHYL N,N DIMETHYL 4H [1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; 1 PHENYL 4H [1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5(6H) ONE; BENZODIAZEPINE DERIVATIVE; INTERLEUKIN 6; N,N DIBUTYL 4H [1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; N,N DIMETHYL 1 PHENYL 4H [1,2,4]TRIAZOLO[4,3 A][1,5]BENZODIAZEPIN 5 AMINE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; LEUKOCYTE MIGRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

EID: 0034960499     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0800     Document Type: Article

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