Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine

Atherosclerosis

Volumn 122, Issue 2, 1996, Pages 201-216

  Matthias, D ^a,d   Becker, C H ^a   Riezler, R ^b   Kindling, P H ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Severi Med GmbH   (Germany)

^c Cardiovasc and TThorac Surgs PA   (United States)

^d Haus 55   (Germany)

Author keywords

Aortic wall; Atherosclerosis; Homocysteine; Light and electron microscopy; Methionine; Mitochondria; Rat

Indexed keywords

HOMOCYSTEINE; METHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ELECTRON MICROSCOPY; HISTOLOGY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; RISK FACTOR; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0029938389     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(95)05740-4     Document Type: Article

References (35)

1. McCully KS. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111.
2. McCully KS, Wilson RB. Homocysteine theory of arteriosclerosis. Atherosclerosis 1975;22:215.
3. McCully KS. Homocysteine theory of arteriosclerosis: Development and current status. Atherosclerosis Reviews 1983;11:157, Gotto AM Jr, Pauletti R (eds.), New York: Raven Press.
4. Kang SS, Wong PWK, Cook HY, Norusis M, Messer JV. Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease. J Clin Invest 1986;77:1482.
5. Refsum H, Helland S, Ueland PM. Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 1985;31:624.
6. Ueland M, Refsum H. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy. J Lab Clin Med 1989;114:473.
7. McCully KS, Ragsdale BD. Production of arteriosclerosis by homocysteinemia. Am J Pathol 1970;61:1.
8. McCully KS. Homocysteinemia and arteriosclerosis. Am Heart J 1972;83:571.
9. McCully KS, Olszewski AJ, Vezeridis MP. Homocysteine and lipid metabolism in atherogenesis: effect of the homocysteine thiolactonyl derivatives, thioretinaco and thiotinamide. Atherosclerosis 1990;83:197.
10. Harker LA, Ross R, Slichter SJ, Scott CR. Homocysteine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest 1976;58:731.
11. Harker LA, Harlan JM, Ross R. Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons, Circ Res 1983;53:731.
12. Krishnaswamy K, Rao SB. Failure to produce atherosclerosis in macaca radiata on a high-methionine, high-fat, pyridoxine-deficient diet. Atherosclerosis 1977;27:253.
13. Reddy GSR, Wilcken DEL. Experimental homocysteinemia in pigs; comparison with studies in sixteen homocysteinuric patients. Metabolism 1982;31:778.
14. Fau D, Peret J, Hadjiisky P. Effect of ingestion of high protein or excess methionine diets by rats for two years. J Nutr 1988;118:128.
15. Hladovec J. Experimental homocystinemia, endothelial lesions and thrombosis. Blood Vessels 1979;16:202.
16. Hladovec J. Methionine, pyridoxine and endothelial lesion in rats. Blood Vessels 1980;17:104.
17. Wilcken DEL, Dudman NPB. Mechanisms of thrombogenesis and accelerated atherogenesis in homocysteinemia. Haemostasis 1989;19(Suppl 1):14.
18. Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986;77:1909.
19. Dudman NPB, Wilcken DEL. Homocysteine thiolactone and experimental homocysteinemia. Biochem Med 1982;27:244.
20. Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 1980;18:115.
21. McCully KS, Vezeridis MP. Histopathological effects of homocysteine thiolacton on epithelial and stromal tissues. Exp Mol Pathol 1989;51:159.
22. Naurath H-J, Riezler R, van den Berg A. Vitamin-B-Mangel - ein Schlüssel zu chronischem Kranksein im Alter? Z Allg Med 1994;70:1.
23. Fieser LF, Rajagopalan S. Selective oxidation with N-bromsuccinimid II of cholestane-3β,5α,6β-triol. J Am Chem Soc 1949;71:3938.
24. Morgenstern E. Simultaneous staining using alcian blue and tannic acid for electron microscopic differentiations of proteins in glycoproteins in blood platelets. Acta Histochem Suppl 1983;28:277.
25. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466.
26. Matthias D, Becker C-H, Gödicke W, Schmidt R, Ponsold K. Actions of cholestane-3β,5α,6β-triol on rats with particular reference of the aorta. Atherosclerosis 1987;63:115.
27. Matthias D, Moritz V, Engler E, Becker C-H. Histomorphologische Gefäß-und Organbefunde und deren Abhängigkeit vom Alter bei spontan hypertonen Ratten einer Linie des Okamoto-Aoki-Stammes. Dt Gesundh-Wesen 1980;35:1630.
28. Mühlbauer St. Die Arteriosklerose von Anfang an verhüten. Therapie mit spezifisch kooperativen Vitaminen gegen die Hyperhomozysteinämie, Fortschr Med 1993;111(Suppl 145):30.
29. Yamori Y, Horie R, Nara Y, Kihara M, Wang H, Ikeda K. Hypertensive rat models of atherosclerosis. In: Scheffler G, Gotto AM, Middelhoff G, Habenicht AJR, Jurutka KR (eds,), Atherosclerosis IV, Berlin:Springer, 1983;144.
30. 6: Relationship to atherosclerosis. J Nutr 1983;113:2122.
31. Murphy-Chutorian DR, Wexman MP, Grieco AJ, Heininger JA, Glassman E, Gaull GE, Feit F, Wexman K, Fox AC. Methionine intolerance: a possible risk factor for coronary artery disease. J Am Coll Cardiol 1985;6:725.
32. Taylor LMJ, DeFrang RD, Harris EJ Jr, Porter JM. The association of elevated plasma homocyt(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg 1991;13:128.
33. Genest JJ, McNamara JR, Salem DN, Wilson PWF, Schaefer EJ, Malinow MR. Plasma homocyst(e)ine levels in men with premature coronary artery disease. J Am Coll Cardiol 1990;16:114.
34. Araki A, Sako Y, Fukushima Y, Matsumoto M, Asada T, Kita T. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects. Atherosclerosis 1989;79:139.
35. Badimon JJ, Fuster V, Chesebro JH, Badimon L. Coronary atherosclerosis. A multifactorial disease. Circulation 1993;87(Suppl II):II-3.