Role of estrogen receptor β in gynecological cancer

Gynecologic Oncology

Volumn 127, Issue 3, 2012, Pages 673-676

  Häring, Julia ^a   Schüler, Susanne ^a   Lattrich, Claus ^a   Ortmann, Olaf ^a   Treeck, Oliver ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Endometrial cancer; Estrogen receptor beta; Ovarian cancer

Indexed keywords

AROMATASE INHIBITOR; ESTROGEN RECEPTOR BETA; FULVESTRANT; TAMOXIFEN;

CANCER CELL; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER PROGNOSIS; DISEASE FREE SURVIVAL; DRUG EFFICACY; ENDOMETRIUM CANCER; HUMAN; OVARY CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

ENDOMETRIAL NEOPLASMS; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; OVARIAN NEOPLASMS;

EID: 84868585838     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.09.006     Document Type: Review

References (67)

1. G.G. Chen, Q. Zeng, and G.M. Tse Estrogen and its receptors in cancer Med Res Rev 28 2008 954 974
2. C. Zhao, K. Dahlman-Wright, and J.Å. Gustafsson Estrogen signaling via estrogen receptor β J Biol Chem 285 2010 39575 39579
3. A.J. Li, R.L. Baldwin, and B.Y. Karlan Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures Am J Obstet Gynecol 189 2003 22 27
4. J. Matthews, and J.A. Gustafsson Estrogen signaling: a subtle balance between ER alpha and ER beta Mol Interv 3 2003 281 292
5. P. Pujol, J.M. Rey, P. Nirde, P. Roger, M. Gastaldi, and F. Laffargue Differential expression of estrogen receptor-alpha and -beta messenger RNAs as a potential marker of ovarian carcinogenesis Cancer Res 58 1998 5367 5373
6. M. Esslimani-Sahla, J. Simony-Lafontaine, A. Kramar, R. Lavaill, C. Mollevi, and M. Warner Estrogen receptor beta (ER beta) level but not its ER beta cx variant helps to predict tamoxifen resistance in breast cancer Clin Cancer Res 10 2004 5769 5776
7. T. Fujimura, S. Takahashi, T. Urano, S. Ogawa, Y. Ouchi, and T. Kitamura Differential expression of estrogen receptor beta (ERbeta) and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic cancer Biochem Biophys Res Commun 289 2001 692 699
8. B.W. Park, K.S. Kim, M.K. Heo, W.I. Yang, S.I. Kim, and J.H. Kim The changes of estrogen receptor beta variants expression in breast carcinogenesis: decrease of estrogen receptor-beta 2 expression is the key event in breast cancer development J Surg Oncol 93 2006 504 510
9. T. Fixemer, K. Remberger, and H. Bonkhoff Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma Prostate 54 2003 79 87
10. E.F. Foley, A.A. Jazaeri, M.A. Shupnik, O. Jazaeri, and L.W. Rice Selective loss of estrogen receptor beta in malignant human colon Cancer Res 60 2000 245 248
11. B.W. Park, K.S. Kim, M.K. Heo, S.S. Ko, S.W. Hong, and W.I. Yang Expression of estrogen receptor-β in normal mammary and tumor tissues: is it protective in breast carcinogenesis? Breast Cancer Res Treat 80 2003 79 85
12. P. Roger, M.E. Sahla, S. Makela, J.A. Gustafsson, P. Baldet, and H. Rochefort Decreased expression of estrogen receptor β protein in proliferative preinvasive mammary tumours Cancer Res 61 2001 2537 2541
13. G.P. Skliris, K. Munot, S.M. Bell, P.J. Carder, S. Lane, and K. Horgan Reduced expression of oestrogen receptor β in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model J Pathol 201 2003 213 220
14. J. Häring, M. Skrzypczak, A. Stegerer, C. Lattrich, F. Weber, and R. Görse Estrogen receptor β transcript variants associate with oncogene expression in endometrial cancer Int J Mol Med 29 2012 1127 1136
15. A. Springwald, C. Lattrich, M. Skrzypczak, R. Goerse, O. Ortmann, and O. Treeck Identification of novel transcript variants of estrogen receptor α, β and progesterone receptor gene in human endometrium Endocrine 37 2010 415 424
16. O. Treeck, G. Pfeiler, D. Mitter, C. Lattrich, G. Piendl, and O. Ortmann Estrogen receptor {beta}1 exerts antitumoral effects on SK-OV-3 ovarian cancer cells J Endocrinol 193 2007 421 433
17. R. Zhou, O. Treeck, F. Horn, and O. Ortmann Effects of prolonged tamoxifen treatment on receptor expression and apoptosis of ovarian cancer cells Gynecol Oncol 96 2005 678 683
18. N. Colombo, T. Van Gorp, G. Parma, F. Amant, G. Gatta, and C. Sessa Ovarian cancer Crit Rev Oncol Hematol 60 2006 159 179
19. A.W. Brandenberger, M.K. Tee, and R.B. Jaffe Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-beta in neoplastic tissues J Clin Endocrinol Metab 83 1998 1025 1028
20. K.K. Chan, N. Wei, S.S. Liu, L. Xiao-Yun, A.N. Cheung, and H.Y. Ngan Estrogen receptor subtypes in ovarian cancer: a clinical correlation Obstet Gynecol 111 2008 144 151
21. I. De Stefano, G.F. Zannoni, M.G. Prisco, A. Fagotti, L. Tortorella, and G. Vizzielli Cytoplasmic expression of estrogen receptor beta (ERβ) predicts poor clinical outcome in advanced serous ovarian cancer Gynecol Oncol 122 2011 573 579
22. T. Rutherford, W.D. Brown, E. Sapi, S. Aschkenazi, A. Muñoz, and G. Mor Absence of estrogen receptor-beta expression in metastatic ovarian cancer Obstet Gynecol 96 2000 417 421
23. F. Suzuki, J. Akahira, I. Miura, T. Suzuki, K. Ito, and S. Hayashi Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5′-untranslated region in human epithelial ovarian carcinoma Cancer Sci 99 2008 2365 2372
24. C. Zhao, E.W. Lam, A. Sunters, E. Enmark, M.T. De Bella, and R.C. Coombes Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation Oncogene 22 2003 7600 7606
25. X. Zhu, I. Leav, Y.K. Leung, M. Wu, Q. Liu, and Y. Gao Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis Am J Pathol 164 2004 2003 2012
26. A. Razin, and H. Ceder DNA methylation and gene expression Microbiol Rev 55 1991 451 458
27. T. Ushijima, and E. Okochi-Takada Aberrant methylations in cancer cells: where do they come from? Cancer Sci 96 2005 206 211
28. A.M. Shaaban, A.R. Green, S. Karthik, Y. Alizadeh, T.A. Hughes, and L. Harkins Nuclear and cytoplasmic expression of ERβ1, ERβ2, and ERβ5 identifies distinct prognostic outcome for breast cancer patients Clin Cancer Res 14 2008 5228 5235
29. Y.K. Leung, H.M. Lam, S. Wu, D. Song, L. Levin, and L. Cheng Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion Endocr Relat Cancer 17 2010 675 689
30. Y. Hayashido, A. Lucas, C. Rougeot, S. Godyna, W.S. Argraves, and H. Rochefort Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin Int J Cancer 75 1998 654 658
31. A. Burges, A. Brüning, C. Dannenmann, T. Blankenstein, U. Jeschke, and N. Shabani Prognostic significance of estrogen receptor α and β expression in human serous carcinomas of the ovary Arch Gynecol Obstet 281 2010 511 517
32. E. Sapi, W.D. Brown, S. Aschkenazi, C. Lim, A. Munoz, and B.M. Kacinski Regulation of Fas ligand expression by estrogen in normal ovary J Soc Gynecol Investig 9 2002 243 250
33. S. Paruthiyil, H. Parmar, V. Kerekatte, G.R. Cunha, G.L. Firestone, and D.C. Leitman Estrogen receptor β inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest Cancer Res 64 2004 423 428
34. A. Ström, J. Hartman, J.S. Foster, S. Kietz, J. Wimalasena, and J.A. Gustafsson Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D Proc Natl Acad Sci U S A 101 2004 1566 1577
35. G. Lazennec Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis Cancer Lett 231 2006 151 157
36. M.M. Liu, C. Albanese, C.M. Anderson, K. Hilty, P. Webb, and R.M. Uht Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression J Biol Chem 277 2002 24353 24360
37. M.D. Planas-Silva, and R.A. Weinberg Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution Mol Cell Biol 17 1997 4059 4069
38. S.D. Worsley, B.A. Ponder, and B.R. Davies Overexpression of cyclin D1 in epithelial ovarian cancers Gynecol Oncol 64 1997 189 195
39. P.R. Lindgren, S. Cajander, T. Backstrom, J.A. Gustafsson, S. Makela, and J.I. Olofsson Estrogen and progesterone receptors in ovarian epithelial tumors Mol Cell Endocrinol 221 2004 97 104
40. K.D. Hatch, J.B. Beecham, J.A. Blessing, and W.T. Creasman Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients Cancer 68 1991 269 271
41. S.K. Gruvberger-Saal, P.O. Bendahl, L.H. Saal, M. Laakso, C. Hegardt, and P. Edén Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma Clin Cancer Res 13 2007 1987 1994
42. L. Hodges-Gallagher, C.D. Valentine, S. El Bader, and P.J. Kushner Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells Breast Cancer Res Treat 109 2008 241 250
43. K. Lindberg, L.A. Helguero, Y. Omoto, J.A. Gustafsson, and L.A. Haldosen Estrogen receptor beta represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN - implications for tamoxifen sensitivity Breast Cancer Res 13 2011 R43
44. X. Wu, M. Subramaniam, S.B. Grygo, Z. Sun, V. Negron, and W.L. Lingle Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen Breast Cancer Res 13 2011 R27
45. V. Speirs, C. Malone, D.S. Walton, M.J. Kerin, and S.L. Atkin Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients Cancer Res 59 1999 5421 5424
46. V. Cappelletti, L. Celio, E. Bajetta, A. Allevi, R. Longarini, and P. Miodini Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients Endocr Relat Cancer 11 2004 761 770
47. H.O. Critchley, T.A. Henderson, R.W. Kelly, G.S. Scobie, L.R. Evans, and N.P. Groome Wild-type estrogen receptor (ERbeta1) and the splice variant (ERbetacx/beta2) are both expressed within the human endometrium throughout the normal menstrual cycle J Clin Endocrinol Metab 87 2002 Nov 5265 5273
48. K. Tamm, M. Rõõm, A. Salumets, and M. Metsis Genes targeted by the estrogen and progesterone receptors in the human endometrial cell lines HEC1A and RL95-2 Reprod Biol Endocrinol 7 2009 Dec 24 150
49. A. Yeramian, G. Moreno-Bueno, X. Dolcet, L. Catasus, M. Abal, and E. Colas Endometrial carcinoma: molecular alterations involved in tumor development and progression Oncogene 2012 10.1038/onc.2012.76 [Epub ahead of print]
50. E. Sivridis, and A. Giatromanolaki The pathogenesis of endometrial carcinomas at menopause: facts and figures J Clin Pathol 64 2011 553 560
51. F. Collins, S. MacPherson, P. Brown, V. Bombail, A.R. Williams, and R.A. Anderson Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha BMC Cancer 9 2009 330
52. T. Smuc, and T.L. Rizner Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer Mol Cell Endocrinol 301 2009 74 82
53. A.W. Brandenberger, D.I. Lebovic, M.K. Tee, I.P. Ryan, J.F. Tseng, and R.B. Jaffe Oestrogen receptor (ER)-alpha and ER-beta isoforms in normal endometrial and endometriosis-derived stromal cells Mol Hum Reprod 5 1999 651 655
54. S. Matsuzaki, T. Fukaya, T. Suzuki, T. Murakami, H. Sasano, and A. Yajima Oestrogen receptor alpha and beta mRNA expression in human endometrium throughout the menstrual cycle Mol Hum Reprod 5 1999 559 564
55. S. Matsuzaki, S. Uehara, T. Murakami, J. Fujiwara, T. Funato, and K. Okamura Quantitative analysis of estrogen receptor alpha and beta messenger ribonucleic acid levels in normal endometrium and ovarian endometriotic cysts using a real-time reverse transcription-polymerase chain reaction assay Fertil Steril 74 2000 753 759
56. I. Mylonas, U. Jeschke, N. Shabani, C. Kuhn, A. Balle, and S. Kriegel Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium Acta Histochem 106 2004 245 252
57. H. Utsunomiya, T. Suzuki, N. Harada, K. Ito, S. Matsuzaki, and R. Konno Analysis of estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic findings in 45 cases Int J Gynecol Pathol 19 2000 335 341
58. D. Chakravarty, R. Srinivasan, S. Ghosh, S. Gopalan, A. Rajwanshi, and S. Majumdar Estrogen receptor beta1 and the beta2/betacx isoforms in nonneoplastic endometrium and in endometrioid carcinoma Int J Gynecol Cancer 17 2007 905 913
59. E. Leygue, H. Dotzlaw, P.H. Watson, and L.C. Murphy Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissue Cancer Res 59 1999 1175 1179
60. M. Skrzypczak, I. Bieche, S. Szymczak, S. Tozlu, S. Lewandowski, and I. Girault Evaluation of mRNA expression of estrogen receptor beta and its isoforms in human normal and neoplastic endometrium Int J Cancer 110 2004 783 787
61. J. Fujimoto, H. Sakaguchi, I. Aoki, H. Toyoki, and T. Tamaya Clinical implications of the expression of estrogen receptor-alpha and -beta in primary and metastatic lesions of uterine endometrial cancers Oncology 62 2002 269 277
62. K. Hu, G. Zhong, and F. He Expression of estrogen receptors ERalpha and ERbeta in endometrial hyperplasia and adenocarcinoma Int J Gynecol Cancer 15 2005 537 541
63. V. Jongen, J. Briët, R. de Jong, K. ten Hoor, M. Boezen, and A. van der Zee Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer Gynecol Oncol 112 2009 537 542
64. I. Mylonas, U. Jeschke, N. Shabani, C. Kuhn, S. Kriegel, and M.S. Kupka Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha (ER-alpha), estrogen receptor beta (ER-beta) and progesterone receptor (PR) Anticancer Res 25 2005 1679 1686
65. I. Mylonas Prognostic significance and clinical importance of estrogen receptor alpha and beta in human endometrioid adenocarcinomas Oncol Rep 24 2010 385 393
66. F. Takama, T. Kanuma, D. Wang, I. Kagami, and H. Mizunuma Oestrogen receptor beta expression and depth of myometrial invasion in human endometrial cancer Br J Cancer 84 2001 545 549
67. N. Shabani, C. Kuhn, S. Kunze, S. Schulze, D. Mayr, and D. Dian Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas Eur J Cancer 43 2007 2434 2444