Prognostic significance of estrogen receptor alpha and beta expression in human serous carcinomas of the ovary

Archives of Gynecology and Obstetrics

Volumn 281, Issue 3, 2010, Pages 511-517

  Burges, Alexander ^a   Brüning, Ansgar ^b   Dannenmann, Christine ^b   Blankenstein, Thomas ^b   Jeschke, Udo ^b   Shabani, Naim ^b,c   Friese, Klaus ^a,b   Mylonas, Ioannis ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c Klinikum Neuperlach   (Germany)

Author keywords

Estrogen receptor alpha; Estrogen receptor beta; Ovarian cancer; Prognostic factors; Serous ovarian carcinomas

Indexed keywords

ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER SURVIVAL; CAUSE SPECIFIC SURVIVAL; DISEASE MARKER; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; OMENTECTOMY; OVARY CARCINOMA; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; SALPINGOOOPHORECTOMY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CYSTADENOCARCINOMA, SEROUS; DISEASE-FREE SURVIVAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LYMPHATIC METASTASIS; MIDDLE AGED; OVARIAN NEOPLASMS; REGISTRIES; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 77950629251     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-009-1185-y     Document Type: Article

References (22)

1. Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C, Vergote I (2006) Ovarian cancer. Crit Rev Oncol Hematol 60(2):159-179
2. Britt KL, Findlay JK (2002) Estrogen actions in the ovary revisited. J Endocrinol 175(2):269-276
3. Cunat S, Hoffmann P, Pujol P (2004) Estrogens and epithelial ovarian cancer. Gynecol Oncol 94(1):25-32
4. Rao GG, Miller DS (2006) Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther 6(1):43-47
5. Koehler KF, Helguero LA, Haldosen LA, Warner M, Gustafsson JA (2005) ReXections on the discovery and signiWcance of estrogen receptor beta. Endocr Rev 26(3):465-478
6. Zhao C, Dahlman-Wright K, Gustafsson JA (2008) Estrogen receptor beta: an overview and update. Nucl Recept Signal 6:e003
7. Dannenmann C, Shabani N, Friese K, Jeschke U, Mylonas I, Bruning A (2008) The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO. Cancer Biol Ther 7(9):1460-1467
8. Chan KK, Wei N, Liu SS, Xiao-Yun L, Cheung AN, Ngan HY (2008) Estrogen receptor subtypes in ovarian cancer: a clinical correlation. Obstet Gynecol 111(1):144-151
9. Geisler JP, Buller E, Manahan KJ (2008) Estrogen receptor alpha and beta expression in a case matched series of serous and endometrioid adenocarcinomas of the ovary. Eur J Gynaecol Oncol 29(2):126-128
10. FIGO stages (announcements)1989-revision. Gynecol Oncol 35:125-127
11. Mylonas I, Jeschke U, Shabani N, Kuhn C, Balle A, Kriegel S, Kupka MS, Friese K (2004) Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium. Acta Histochem 106(3):245-252
12. Mylonas I, Jeschke U, Shabani N, Kuhn C, Kriegel S, Kupka MS, Friese K (2005) Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha (ER-alpha), estrogen receptor beta (ER-beta) and progesterone receptor (PR). Anticancer Res 25(3A):1679-1686
13. Mylonas I, Jeschke U, Shabani N, Kuhn C, Kunze S, Dian D, Friedl C, Kupka MS, Friese K (2007) Steroid receptors ERalpha, ERbeta, PR-A and PR-B are differentially expressed in normal and atrophic human endometrium. Histol Histopathol 22(2):169-176
14. Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindlbeck C, Willgeroth F, Sommer H et al (2007) Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer 43(16):2434-2444
15. Remmele W, Stegner HE (1987) Vorschlag zur einheitlichen Definierung eines immunreaktiven Score (IRS) für den immunhistochemischen Östrogenrezeptornachweis (ER-ICA) im Mammakarzinomgewebe. Pathologe 8:138-140
16. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
17. Cox DR (1972) Regression models and life tables. J R Stat Soc B34:187-220
18. O'Donnell AJ, Macleod KG, Burns DJ, Smyth JF, Langdon SP (2005) Estrogen receptor-alpha mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen. Endocr Relat Cancer 12(4):851-866
19. Lazennec G (2006) Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis. Cancer Lett 231(2):151-157
20. Treeck O, Pfeiler G, Mitter D, Lattrich C, Piendl G, Ortmann O (2007) Estrogen receptor {beta}1 exerts antitumoral eVects on SK-OV-3 ovarian cancer cells. J Endocrinol 193(3):421-433
21. Wong KK, Lu KH, Malpica A, Bodurka DC, Shvartsman HS, Schmandt RE, Thornton AD, Deavers MT, Silva EG, Gershenson DM (2007) SigniWcantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis. Int J Gynecol Pathol 26(4):404-409
22. Hogdall EV, Christensen L, Hogdall CK, Blaakaer J, Gayther S, Jacobs IJ, Christensen IJ, Kjaer SK (2007) Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study. Oncol Rep 18(5):1051-1059