Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures

American Journal of Obstetrics and Gynecology

Volumn 189, Issue 1, 2003, Pages 22-27

  Li, Andrew J ^a   Baldwin, Rae Lynn ^a   Karlan, Beth Y ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Estrogen receptor; Ovarian cancer; Progesterone receptor

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 0037660827     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2003.328     Document Type: Article

References (25)

1. Risch HA. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 1998; 90:1774-86.
2. Fathalla MF. Incessant ovulation: a factor in ovarian neoplasia? [letter] Lancet 1971;2:163.
3. Franceschi S, Parazzini F, Negri E, Booth M, La Vecchia C, Beral V, et al. Pooled analysis of 3 European case-control studies of epithelial ovarian cancer, III: oral contraceptive use. Int J Cancer 1991;49:61-5.
4. Whittemore AS, Harris R, Itnyre J. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies, II: invasive epithelial ovarian cancers in white women: Collaborative Ovarian Cancer Group. Am J Epidemiol 1992; 136:1184-203.
5. Bu SZ, Yin DL, Ren XH, Jiang LZ, Wu ZJ, Gao QR, et al. Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Cancer 1997;79:1944-50.
6. Formby B, Wiley TS. Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53. Ann Clin Lab Sci 1998;28:360-9.
7. Enmark E, Gustafsson JA. Oestrogen receptors: an overview. J Int Med 1999;246:133-8.
8. McDonnell DP. Selective estrogen receptor modulators (SERMs): a first step in the development of perfect hormone replacement therapy regimen. J Soc Gynecol Investig 2000;7 (Suppl): S10-5.
9. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997;138:863-70.
10. Conneely OM, Kettelberger DM, Tsai MJ, Schrader WT, O'Malley BW. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem 1989;264:14062-4.
11. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronenmeyer H, et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 1990;9:1603-14.
12. Conneely OM, Lydon JP, De Mayo F, O'Malley BW. Reproductive functions of the progesterone receptor. J Soc Gynecol Investig 2000;7:S25-32.
13. Pujol P, Rey JM, Nirde P, Roger P, Gastaldi M, Laffargue F, et al. Differential expression of estrogen receptor-α and -β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res 1998;58:5367-73.
14. Brandenberger AW, Tee MK, Jaffe RB. Estrogen receptor alpha (ER-α) and beta (ER-β) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-β in neoplastic tissues. J Clin Endocrinol Metab 1998; 83:1025-8.
15. Lau KM, Mok SC, Ho SM. Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci U S A 1999;96:5722-7.
16. Rutherford T, Brown WD, Sapi E, Ashkenazi S, Munoz A, Mor G. Absence of estrogen receptor-β expression in metastatic ovarian cancer. Obstet Gynecol 2000;96:417-21.
17. Karlan BY, Jones J, Greenwald M, Lagasse LD. Steroid hormone effects on the proliferation of human ovarian surface epithelium in vitro. Am J Obstet Gynecol 1995;173:97-104.
18. Baldwin RL, Tran H, Karlan BY. Primary ovarian cancer cultures are resistant to Fas-mediated apoptosis. Gynecol Oncol 1999; 74:265-71.
19. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci U S A 1998;95:677-82.
20. Gustafsson JA. Novel aspects of estrogen action. J Soc Gynecol Investig 2000;7 (Suppl):8-9.
21. Casanova M, You L, Gaido KW, Archibeque-Engle S, Janszen DB, Heck HA. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. Toxicol Sci 1999;51:236-44.
22. Shen F, Weber G. Synergistic action of quercetin and genistein in human ovarian carcinoma cells. Oncol Res 1997;9:597-602.
23. Prins GS, Marmer M, Woodham C, Chang W, Kuiper G, Gustafsson JA, et al. Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal estrogen exposure on the expression pattern. Endocrinology 1998;139:874-83.
24. Giangrande PH, Kimbrel EA, Edwards, DP, McDonnell DP. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol 2000;20:3102-15.
25. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. Subgroup of reproductive functions of progesterone mediated by progesterone receptor B isoform. Science 2000;289:1751-4.