Prognostic significance of oestrogen receptor alpha (ERα) and beta (ERβ), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas

European Journal of Cancer

Volumn 43, Issue 16, 2007, Pages 2434-2444

  Shabani, Naim ^a,b   Kuhn, Christina ^a   Kunze, Susanne ^a   Schulze, Sandra ^a   Mayr, Doris ^a   Dian, Darius ^a   Gingelmaier, Andrea ^a   Schindlbeck, Christian ^a   Willgeroth, Franz ^a   Sommer, Harald ^a   Jeschke, Udo ^a   Friese, Klaus ^a   Mylonas, Ioannis ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Landeskrankenhaus Schärding ^*  (Austria)

Author keywords

Cancer; Endometrium; Immunohistochemistry; Oestrogen receptor alpha (ER ); Oestrogen receptor beta (ER ); Progesterone receptor A (PR A); Progesterone receptor B (PR B); Prognostic significance; Survival

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MONOCLONAL ANTIBODY; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B;

ADULT; AGED; ARTICLE; CANCER STAGING; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ENDOMETRIAL NEOPLASMS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL;

EID: 35548960893     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2007.08.014     Document Type: Article

References (30)

1. Creasman W.T. Endometrial cancer: incidence, prognostic factors, diagnosis, and treatment. Semin Oncol 24 (1997) S1-140-S1-150
2. Oreskovic S., Babic D., Kalafatic D., Barisic D., and Beketic-Oreskovic L. A significance of immunohistochemical determination of steroid receptors, cell proliferation factor Ki-67 and protein p53 in endometrial carcinoma. Gynecol Oncol 93 (2004) 34-40
3. Kuiper G.G., Shughrue P.J., Merchenthaler I., and Gustafsson J.A. The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Front Neuroendocrinol 19 (1998) 253-286
4. Graham J.D., and Clarke C.L. Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Res 4 (2002) 187-190
5. Kumar N.S., Richer J., Owen G., Litman E., Horwitz K.B., and Leslie K.K. Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action. Cancer Res 58 (1998) 1860-1865
6. Mylonas I., Jeschke U., Shabani N., et al. Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha (ER-α), estrogen receptor beta (ER-β) and progesterone receptor (PR). Anticancer Res 25 (2005) 1679-1686
7. Mylonas I., Jeschke U., Shabani N., et al. Steroid receptors ERα, ERβ, PR-A and PR-B are differentially expressed in normal and atrophic human endometrium. Histol Histopathol 22 (2007) 169-176
8. Kadar N., Malfetano J.H., and Homesley H.D. Steroid receptor concentrations in endometrial carcinoma: effect on survival in surgically staged patients. Gynecol Oncol 50 (1993) 281-286
9. Creasman W.T. Prognostic significance of hormone receptors in endometrial cancer. Cancer 71 (1993) 1467-1470
10. Nyholm H.C., Christensen I.J., and Nielsen A.L. Progesterone receptor levels independently predict survival in endometrial adenocarcinoma. Gynecol Oncol 59 (1995) 347-351
11. Fukuda K., Mori M., Uchiyama M., Iwai K., Iwasaka T., and Sugimori H. Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol 69 (1998) 220-225
12. Kleine W., Maier T., Geyer H., and Pfleiderer A. Estrogen and progesterone receptors in endometrial cancer and their prognostic relevance. Gynecol Oncol 38 (1990) 59-65
13. Lukes A.S., Kohler M.F., Pieper C.F., et al. Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer 73 (1994) 2380-2385
14. Sivridis E., Giatromanolaki A., Koukourakis M., and Anastasiadis P. Endometrial carcinoma: association of steroid hormone receptor expression with low angiogenesis and bcl-2 expression. Virchows Arch 438 (2001) 470-477
15. Sobin L.H., and Wittekind C. TNM classification of malignant tumours (2002), John Wiley, Hoboken (NJ)
16. FIGO stages (announcements) - revision. Gynecol Oncol 1989;35:125-7.
17. Pertschuk L.P., Masood S., Simone J., et al. Estrogen receptor immunocytochemistry in endometrial carcinoma: a prognostic marker for survival. Gynecol Oncol 63 (1996) 28-33
18. Remmele W., and Stegner H.E. Vorschlag zur einheitlichen Definierung eines immunreaktiven Score (IRS) für den immunhistochemischen Östrogenrezeptornachweis (ER-ICA) im Mammakarzinomgewebe. Pathologe 8 (1987) 138-140
19. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
20. Cox D.R. Regression models and life tables. J R Stat Soc B 34 (1972) 187-220
21. Jereczek-Fossa B., Badzio A., and Jassem J. Surgery followed by radiotherapy in endometrial cancer: analysis of survival and patterns of failure. Int J Gynecol Cancer 9 (1999) 285-294
22. Jeon Y.T., Park I.A., Kim Y.B., et al. Steroid receptor expressions in endometrial cancer: clinical significance and epidemiological implication. Cancer Lett 239 (2006) 198-204
23. Takama F., Kanuma T., Wang D., Kagami I., and Mizunuma H. Oestrogen receptor beta expression and depth of myometrial invasion in human endometrial cancer. Br J Cancer 84 (2001) 545-549
24. Fujimoto J., Sakaguchi H., Aoki I., Toyoki H., and Tamaya T. Clinical implications of the expression of estrogen receptor-α and -β in primary and metastatic lesions of uterine endometrial cancers. Oncology 62 (2002) 269-277
25. Mulac-Jericevic B., Mullinax R.A., DeMayo F.J., Lydon J.P., and Conneely O.M. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 289 (2000) 1751-1754
26. Lydon J.P., DeMayo F.J., Funk C.R., et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 9 (1995) 2266-2278
27. Morris P.C., Anderson J.R., Anderson B., and Buller R.E. Steroid hormone receptor content and lymph node status in endometrial cancer. Gynecol Oncol 56 (1995) 406-411
28. Palmer D.C., Muir I.M., Alexander A.I., Cauchi M., Bennett R.C., and Quinn M.A. The prognostic importance of steroid receptors in endometrial carcinoma. Obstet Gynecol 72 (1988) 388-393
29. Sakaguchi H., Fujimoto J., Hong B.L., Nakagawa Y., and Tamaya T. Drastic decrease of progesterone receptor form B but not A mRNA reflects poor patient prognosis in endometrial cancers. Gynecol Oncol 93 (2004) 394-399
30. Miyamoto T., Watanabe J., Hata H., et al. Significance of progesterone receptor-A and -B expressions in endometrial adenocarcinoma. J Steroid Biochem Mol Biol 92 (2004) 111-118