Loss of estrogen receptor β isoform expression and its correlation with aberrant DNA methylation of the 5′-untranslated region in human epithelial ovarian carcinoma

Cancer Science

Volumn 99, Issue 12, 2008, Pages 2365-2372

  Suzuki, Fumihiko ^a   Akahira, Jun Ichi ^a   Miura, Ikumi ^a   Suzuki, Takashi ^a   Ito, Kiyoshi ^a   Hayashi, Shin Ichi ^a   Sasano, Hironobu ^a   Yaegashi, Nobuo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA 1; ESTROGEN RECEPTOR BETA 2; ESTROGEN RECEPTOR BETA 4; ISOPROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CLEAR CELL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; EPITHELIUM CELL; EXON; FEMALE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

5' UNTRANSLATED REGIONS; CASE-CONTROL STUDIES; DNA METHYLATION; EPITHELIAL CELLS; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; OVARIAN NEOPLASMS; PROTEIN ISOFORMS; RETROSPECTIVE STUDIES; RNA, MESSENGER;

EID: 57349198790     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00988.x     Document Type: Article

References (40)

1. Akahira J, Suzuki T, Ito K et al. Expression of 5α-reductases in human epithelial ovarian cancer: Its correlation with androgen receptor status. Jpn J Cancer Res 2001; 92: 926-32.
2. Rao BR, Slotman BJ. Endocrine factors in common epithelial ovarian cancer. Endocrine Rev 1991; 12: 14-26.
3. Akahira J, Inoue T, Suzuki T et al. Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: Immunohistochemical and RT-PCR studies. Br J Cancer 2000; 83: 1488-94.
4. McGuire WL. Steroid receptors in human breast cancer. Cancer Res 1978; 38: 4289-91.
5. Ehrlich CE, Young PLM, Cleary RE. Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic and carcinomatous endometria: Therapeutic implications. Am J Obstet Gynecol 1981; 141: 539-46.
6. Saito S, Ito K, Nagase S, Suzuki T et al. Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma. Cancer Sci 2006; 97: 1308-14.
7. Moore JT, McKee DD, Slentz-Kesler K et al. Cloning and characterization of human estrogen receptor β isoforms. Biochem Biophys Res Commun 1998; 247: 75-8.
8. Akahira J, Yoshikawa H, Shimizu Y et al. Prognostic factors of stage IV epithelial ovarian cancer: A multicenter retrospective study. Gynecol Oncol 2001; 81: 398-403.
9. Hatch KD, Beecham JB, Blessing JA et al. Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients. Cancer 1991; 68: 269-71.
10. Scambia G, Benedetti-Panici P, Ferrandina G et al. Epidermal growth factor, oestrogen and progesterone receptor expression in primary ovarian cancer: Correlation with clinical outcome and response to chemotherapy. Br J Cancer 1995; 72: 361-6.
11. Mangelsdorf DJ, Thumnel C, Beato M et al. The nuclear receptor superfamily: The second decade. Cell 1995; 83: 835-9.
12. Ogawa S, Inoue S, Watanabe T et al. Molecular cloning and characterization of human estrogen receptor beta cx: A potential inhibitor of estrogen action in human. Nucl Acids Res 1998; 26: 3505-12.
13. Hirata S, Shoda T, Kato J et al. The multiple untranslated first exons system of the human estrogen receptor β (ER β) gene. J Steroid Biochem Mol Biol 2001; 78: 33-40.
14. Ushijima T, Okochi-Takada E. Aberrant methylations in cancer cells: where do they come from? Cancer Sci 2005; 96: 206-11.
15. Razin A, Ceder H. DNA methylation and gene expression. Microbiol Rev 1991; 55: 451-8.
16. Esteller M, Corn PG, Baylin SB et al. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61: 3225-9.
17. Dotzlaw H, Leygue E, Watson PH et al. Estrogen receptor-β messenger RNA expression in human breast tumor biopsies: Relationship to steroid receptor status and regulation by progestins. Cancer Res 1999; 59: 529-32.
18. Tong D, Schuster E, Seifert M et al. Expression of estrogen receptor beta isoforms in human breast cancer tissues and cell lines. Breast Cancer Res Treat 2002; 71: 249-55.
19. Zhao C, Lam EW, Sunters A et al. Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: Regulation by methylation. Oncogene 2003; 22: 7600-6.
20. Zhu X, Leav I, Leung Y et al. Dynamic regulation of estrogen receptor-β expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol 2004; 164: 2003-12.
21. Pujol P, Rey JM, Nirde P et al. Differential expression of estrogen receptor-α and -β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res 1998; 58: 5367-73.
22. Brandenberger AW, Tee MK, Jaffe RB. Estrogen receptor alpha (ER-α) and beta (ER-β) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: Down-regulation of ER-β in neoplastic tissues. J Clin Endocrinol Metab 1998; 83: 1025-8.
23. Rutherford T, Brown WD, Sapi E et al. Absence of estrogen receptor-β expression in metastatic ovarian cancer. Obstet Gynecol 2000; 96: 417-21.
24. Bardin A, Hoffmann P, Boulle N et al. Involvement of estrogen receptor β in ovarian carcinogenesis. Cancer Res 2004; 64: 5861-9.
25. Shimizu Y, Kamoi S, Amada S et al. Toward the development of a universal grading system for ovarian epithelial carcinoma. Prognostic significance of histopathologic features - problems involved in the architectural grading system. Gynecol Oncol 1998; 70: 2-12.
26. Nitta M, Katabuchi H, Ohtake H et al. Characterization and tumorigenicity of human ovarian surface epithelial cells immortalized by SV40 large T antigen. Gynecol Oncol 2001; 81: 10-17.
27. Wong KK, Tsang YT, Chang YM et al. Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res 2006; 66: 11 172-8.
28. Campbell-Thompson M, Lynch IJ, Bhardwaj B. Expression of estrogen receptor (ER) subtypes and ERβ isoforms in colon cancer. Cancer Res 2001; 61: 632-40.
29. Leygue E, Dotzlaw H, Watson PH et al. Expression of estrogen receptor β1, β2, and β5 messenger RNAs in human breast tissue. Cancer Res 1999; 59: 1175-9.
30. Fujimura T, Takahashi S, Urano T et al. Differential expression of estrogen receptor β (ERβ) and its C-terminal truncated splice variant ERβcx as prognostic predictors in human prostatic cancer. Biochem Biophys Res Commun 2001; 289: 692-9.
31. Leung YK, Mak P, Hassan S, Ho SM. Estrogen receptor (ER)-β isoforms: A key to understanding ER-β signaling. Proc Natl Acad Sci USA 2006; 103: 13 162-7.
32. Skrzypczak M, Bieche I, Szymczak S et al. Evaluation of mRNA expression of estrogen receptor beta and its isoforms in human normal and neoplastic endometrium. Int J Cancer 2004; 110: 783-7.
33. Chu S, Mamers P, Burger HG et al. Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors. Clin Endocrinol Metab 2000; 85: 1200-5.
34. Omoto Y, Eguchi H, Yamamoto-Yamaguchi Y et al. Estrogen receptor (ER) β1 and ERβcx/β2 inhibit ERα function differently in breast cancer cell line MCF7. Oncogene 2003; 22: 5011-20.
35. 2 cell cycle arrest. Cancer Res 2004; 64: 423-8.
36. Weihua Z, Makela S, Andersson LC et al. A role for estrogen receptor β in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 2001; 98: 6330-5.
37. Tan DSP, Kaye S. Ovarian clear cell adenocarcinoma: A continuing enigma. J Clin Pathol 2007; 60: 355-60.
38. Herynk MH, Fuqua SAW. Estrogen receptor mutations in human disease. Endocr Rev 2004; 25: 869-98.
39. Leung YK, Mak P, Singh L et al. Transcriptional regulation of novel and know estrogen receptor-β isoforms during prostate carcinogenesis. Proc Amer Assoc Cancer Res 2005; 46: 749.
40. Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol 1987; 196: 261-82.