Wild-type estrogen receptor (ERβ1) and the splice variant (ERβcx/β2) are both expressed within the human endometrium throughout the normal menstrual cycle

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 11, 2002, Pages 5265-5273

  Critchley, Hilary O D ^a,b,c   Henderson, Teresa A ^a,b,c   Kelly, Rodney W ^a,b,c   Scobie, Graeme S ^a,b,c   Evans, Lee R ^a,b,c   Groome, Nigel P ^a,b,c   Saunders, Philippa T K ^a,b,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ESTRADIOL; ESTROGEN RECEPTOR BETA; MESSENGER RNA; MONOCLONAL ANTIBODY; PROGESTERONE; RECEPTOR SUBTYPE; SYNTHETIC PEPTIDE;

ANTIBODY SPECIFICITY; ARTICLE; ENDOMETRIUM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MENSTRUAL CYCLE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

ALTERNATIVE SPLICING; ANTIBODIES, MONOCLONAL; CELL NUCLEUS; ENDOMETRIUM; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MENSTRUAL CYCLE; PROGESTERONE; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VARIATION (GENETICS);

EID: 0036845348     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020502     Document Type: Article

References (48)

1. Critchley HOD, Brenner RM, Drudy TA, Williams KA, Nayak NR, Millar MR, Saunders PTK 2001 Estrogen receptor β, but not estrogen receptor α, is present in the vascular endothelium of the human and nonhuman primate endometrium. J Clin Endocrinol Metab 86:1370-1378
2. Garcia E, Bouchard P, De Brux J 1998 Use of immunocytochemistry of progesterone and oestrogen receptors for endometrial dating. J Clin Endocrinol Metab 67:80-97
3. Snijders MP, de Geoij AFPM, Debets-Te Baerts MJC, Rousch MJM, Koudstaal J, Bosman FT 1992 Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause. J Reprod Fertil 94:363-371
4. Lessey BA, Killam AP, Metzger DA, Haneyt AF, Greene GL, McKarty KS 1988 Immunohistochemical analysis of human uterine oestrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 67:334-340
5. Lecce G, Meduri G, Ancelin M, Bergeron C, Perrot-Applanat M 2001 Presence of estrogen receptor β in the human endometrium through the cycle: Expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab 86:1379-86
6. Mertens HJ, Heineman MJ, Theunissen PH, de Jong FH, Evers JL 2001 Androgen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle. Eur J Obstet Gynecol Reprod Biol 98:58-65
7. Slayden OD, Nayak NR, Burton KA, Chwalisz K, Cameron ST, Critchley HO, Baird DT, Brenner RM 2001 Progesterone antagonists increase androgen receptor expression in the rhesus macaque and human endometrium. J Clin Endocrinol Metab 86:2668-2679
8. Beato M, Klug J 2000 Steroid hormone receptors: An update. Hum Reprod Update 6:225-236
9. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjold M, Gustafsson J-A 1997 Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82:4258-4265
10. Sundarrajan C, Liao WX, Roy AC, Ng SC 2001 Association between estrogen receptor-β gene polymorphisms and ovulatory dysfunctions in patients with menstrual disorders. J Clin Endocrinol Metab 86:135-139
11. Sundarrajan C, Liao W, Roy AC, Ng SC 1999 Association of oestrogen receptor gene polymorphisms with outcome of ovarian stimulation in patients undergoing IVF. Mol Hum Reprod 5:797-802
12. Ogawa S, Emi M, Shiraki M, Hosoi T, Ouchi Y, Inoue S 2000 Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure. J Hum Genet 45:327-330
13. Westberg L, Baghaei F, Rosmond R, Hellstrand M, Landen M, Jansson M, Holm G, Bjorntorp P, Eriksson E 2001 Polymorphisms of the androgen receptor gene and the estrogen receptor β gene are associated with androgen levels in women. J Clin Endocrinol Metab 86:2562-2568
14. Kitawaki J, Obayashi H, Ishihara H, Koshiba H, Kusuki I, Kado N, Tsukamoto K, Hasegawa G, Nakamura N, Honjo H 2001 Oestrogen receptor-α gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod 16:51-55
15. Malamitsi-Puchner A, Tziotis J, Evangelopoulos D, Fountas L, Vlachos G, Creatsas G, Sekeris CE, Moutsatsou P 2001 Gene analysis of the N-terminal region of the estrogen receptor α in preeclampsia. Steroids 66:695-700
16. Cowley SM, Hoare S, Mosselman S, Parker SG 1997 Estrogen receptors α and β form heterodimers on DNA. J Biol Chem 272:19858-19862
17. Pettersson K, Grandien K, Kuiper GGJM, Gustafsson J-A 1997 Mouse estrogen receptor β forms estrogen receptor response element-binding heterodimers with estrogen receptor α. Mol Endocrinol 11:1486-1496.
18. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson J-A, Kushner PJ, Scanlan TS 1997 Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510
19. Hall JM, McDonnell DP 1999 The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140:5566-5578
20. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M 1998 Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human. Nucleic Acids Res 26:3505-3512
21. Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM, Willson TM 1998 Cloning and characterisation of human estrogen receptor β isoforms. Biochem Biophys Res Commun 247:75-78
22. Mosselman S, Polman J, Dijkema R 1996 ERβ: Identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53
23. Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, Ouchi Y, Muramatsu M 1998 The complete primary structure of human estrogen receptor β (hERβ) and its heterodimerization with ERα in vivo and in vitro. Biochem Biophys Res Commun 243:122-126
24. Inoue S, Ogawa S, Horie K, Hoshino S, Goto W, Hosoi T, Tsutsumi O, Muramatsu M, Ouchi Y 2000 An estrogen receptor β isoform that lacks exon 5 has dominant negative activity on both ERα and ERβ. Biochem Biophys Res Commun 279:814-819
25. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA 2001 Mechanisms of estrogen action. Physiol Rev 81:1535-1565
26. Noyes RW, Hertig AT, Rock J 1950 Dating the endometrial biopsy. Fertil Steril 1:3-25
27. Yong EL, Glasier A, Hillier H, Ledger W, Caird L, Beattie G, Sweeting V, Thong J, Baird DT 1992 Effect of cyclofenil on hormonal dynamics, follicular development and cervical mucus in normal and oligomenorrhoeic women. Hum Reprod 7:39-43
28. Saunders PTK, Millar MR, Williams K, Macpherson S, Harkiss D, Anderson RA, Orr B, Groome NP, Scobie G, Fraser HM 2000 Differential expression of estrogen receptor-α and -β and androgen receptor in the ovaries of marmoset and human. Biol Reprod 63:1098-1105
29. Saunders PTK, Millar MR, Macpherson S, Irvine DS, Groome NP, Evans LR, Sharpe RM, Scobie GA 2002 Estrogen receptor β (ERβ1), and the estrogen receptor β2 splice variant (ERβcx/2), are expressed in distinct cell populations in the adult human testis. J Clin Endocrinol Metab 87:2706-2715
30. Wang JD, Fu Y, Shi WL 1992 Immunohistochemical localization of progesterone B receptor in human decidua in early pregnancy. Hum Reprod 7:123-127
31. Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS 1999 Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-a or estrogen receptor-β. Endocrinology 140:800-804
32. Rey JM, Pujol P, Dechaud H, Edouard E, Hedon B, Maudelonde T 1998 Expression of oestrogen receptor-α splicing variants and oestrogen receptor-β in endometrium of infertile patients. Mol Hum Reprod 4:641-647
33. Matsuzaki S, Uehara S, Murakami T, Fujiwara J, Funato T, Okamura K 2000 Quantitative analysis of estrogen receptor α and β messenger ribonucleic acid levels in normal endometrium and ovarian endometriotic cysts using a real-time reverse transcription-polymerase chain reaction assay. Fertil Steril 74:753-759
34. Matsuzaki S, Fukaya T, Suzuki T, Murakami T, Sasano H, Yajima A 1999 Oestrogen receptor α and β mRNA expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod 5:559-564
35. Brandenberger AW, Lebovic DI, Tee MK, Ryan IP, Tseng JF, Jaffe RB, Taylor RN 1999 Oestrogen receptor (ER)-α and ER-β isoforms in normal endometrial and endometriosis-dervived stromal cells. Mol Hum Reprod 5:651-655
36. Loke YW, King A 1995 Uterine mucosal leucocytes. In: Human Implantation: Cell Biology and Immunology. Cambridge: Cambridge University Press; 102-129
37. Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H, Sahlin L 2001 Co-localisation of estrogen receptor β and leukocyte markers in the human cervix. Mol Hum Reprod 7:881-886
38. Saunders PTK, Sharpe RM, Williams K, Macpherson S, Urquhart H, Irvine DS, Millar MR 2001 Differential expression of oestrogen receptor α and β proteins in the testes and male reproductive system of human and non-human primates. Mol Hum Reprod 7:227-236
39. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-A 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138:863-870
40. Klinge CM 2000 Estrogen receptor interaction with co-activators and co-repressors. Steroids 65:227-251
41. Teng CT, Gladwell W, Beard C, Walmer D, Teng CS, Brenner R 2002 Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium. Mol Hum Reprod 8:58-67
42. Meduri G, Bausero P, Perrot-Applanat M 2000 Expression of vascular endothelial growth factor receptors in the human endometrium: Modulation during the menstrual cycle. Biol Reprod 62:439-447
43. Chauchereau A, Savouret JF, Milgrom E 1992 Control of biosynthesis and post-transcriptional modification of progesterone receptor. Biol Reprod 46:174-177
44. Savouret JF, Bailly A, Misrahi M, Rauch C, Redeuilh G, Chauchereau A, Milgrom E 1991 Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene. EMBO J 10:1875-1883
45. Kraus WL, Montano MM, Katzenellenbogen BS 1994 Identification of multiple, widely spaced estrogen-responsive regions in the rat progesterone receptor gene. Mol Endocrinol 8:952-969
46. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN 1996 Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81:3112-3118
47. Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN 2000 Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β. Proc Natl Acad Sci USA 97:10972-10977
48. Katzenellenbogen BS, Katzenellenbogen JA 2000 Estrogen receptor transcription and transactivation: Estrogen receptor α and estrogen receptor β: Regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2:335-344