Alpha2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity

Neuroscience

Volumn 228, Issue , 2013, Pages 23-35

  Cai, J ^a,b   Li, J ^a,b   Liu, W ^a,b   Han, Y ^a   Wang, H ^a,b  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b Shandong Provincial Key Laboratory of Otology   (China)

Author keywords

2 adrenergic receptors; Brimonidine; Glutamate; Hydrogen peroxide; Spiral ganglion neurons; Yohimbine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACRIDINE ORANGE; ALPHA 2 ADRENERGIC RECEPTOR; ARTEMIN; BRIMONIDINE; CASPASE 3; CASPASE 9; GLUTAMIC ACID; HOE 33342; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; YOHIMBINE; NEUROPROTECTIVE AGENT; QUINOXALINE DERIVATIVE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; GLUTAMATE NEUROTOXICITY; HYDROGEN PEROXIDE NEUROTOXICITY; IMMUNOFLUORESCENCE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPIRAL GANGLION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; PHYSIOLOGY;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENTS; QUINOXALINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SPIRAL GANGLION; YOHIMBINE;

EID: 84868583013     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.10.004     Document Type: Article

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