The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea

Neuropharmacology

Volumn 39, Issue 11, 2000, Pages 1959-1973

  Ruel, J ^a   Bobbin, R P ^b   Vidal, D ^a   Pujol, R ^a   Puel, J L ^a  

^a UNIV MONTPELLIER   (France)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptors; Co2+ uptake; Cochlea; Excitotoxicity; GYKI 53784 (LY303070); Synaptic transmission

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; CALCIUM; COBALT;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; COCHLEA; COCHLEAR NERVE; DRUG EFFECT; GUINEA PIG; IMMUNOHISTOCHEMISTRY; NERVE CONDUCTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

ACTION POTENTIALS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZODIAZEPINES; COCHLEA; COCHLEAR NERVE; EXCITATORY AMINO ACID AGONISTS; GUINEA PIGS; HAIR CELLS, INNER; RECEPTORS, AMPA;

EID: 0033837437     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00069-1     Document Type: Article

References (38)

1. Baudry M. Functions and regulations of glutamate receptors. Roberts P.J., Storm-Mathisen J., Bradfort H.F. Excitatory Amino Acids. 1986;301-321 Macmillan Press, London.
2. Bleakman D., Bally B.A., Schoepp D.D., Palmer A.J., Bath C.P., Sharpe E.F.et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology. 35:1996;1689-1702.
3. Bledsoe S.C. Jr., Bobbin R.P., Chihal D.M. Kainic acid: an evaluation of its action on cochlear potentials. Hearing Research. 4:1981;109-120.
4. Bobbin R.P. Glutamate and aspartate mimic the afferent transmitter in the cochlea. Experimental Brain Research. 34:1979;389-393.
5. Bobbin R.P., Bledsoe S.C. Jr., Jenison G.L. Neurotransmitters of the cochlea and the lateral line organ. Berlin C.I. Hearing Sciences, Recent Advances. 1984;159-180 College Hill Press, San Diego.
6. Boulter J., Hollmann M., O'Shea-Greenfield A., Hartley M., Deneris E.S., Maron C.et al. Molecular cloning and functional expression of glutamate receptors subunit genes. Science. 249:1990;1033-1037.
7. Choi D.W., Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annual Review of Neuroscience. 13:1990;171-182.
8. Comis S.D., Leng G. Action of putative neurotransmitters in the guinea pig cochlea. Experimental Brain Research. 36:1979;119-128.
9. d'Aldin C.G., Ruel J., Assié R., Pujol R., Puel J.L. Implication of NMDA type glutamate receptors in neural regeneration and neoformation of synapses after excitotoxic injury in the guinea pig cochlea. International Journal of Developmental Neuroscience. 15:1997;619-629.
10. d'Aldin C.G., Caicedo A., Ruel J., Renard N., Pujol R., Puel J.L. Antisense oligonucleotides to the GluR2 AMPA receptor subunit modify excitatory synaptic transmission in vivo. Molecular Brain Research. 55:1998;151-164.
11. Donevan S.D., Rogawski M.A. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 10:1993;51-59.
12. Eybalin M., Altschuler R.A. Immunoelectron microscopic localization of neurotransmitters in the cochlea. Journal of Electron Microscopy Technique. 15:1990;209-224.
13. Felix D., Ehrenberger K. A microiontophoretic study of the role of excitatory amino acids at the afferent synapses of mammalian inner hair cells. European Archives of Oto-Rhino-Laryngology. 248:1990;1-3.
14. Gleich O., Johnstone B.M., Robertson D. Effects of L-glutamate on auditory afferent activity in view of its proposed excitatory transmitter role in the mammalian cochlea. Hearing Research. 45:1990;295-312.
15. Hollmann M., Heinemann S. Cloned glutamate receptors. Annual Review of Neuroscience. 17:1994;31-108.
16. Jenison G.L., Bobbin R.P. Quisqualate excites spiral ganglion neurons of the guinea pig. Hearing Research. 20:1985;261-265.
17. Juiz J.M., Rueda J., Merchán J.A., Sala M.L. The effects of kainic acid on the cochlear ganglion of the rat. Hearing Research. 40:1989;65-74.
18. Keinanen K., Wisden W., Sommer B., Werner P., Herb A., Verdoorn T.A.et al. A family of AMPA-selective glutamate receptors. Science. 249:1990;556-560.
19. Littman T., Bobbin R.P., Fallon M., Puel J.L. The quinoxalediones DNQX, CNQX and two related congeners suppress hair cell-to-auditory nerve transmission. Hearing Research. 40:1989;45-54.
20. Matsubara A., Laake J.H., Davanger D., Usami S., Ottersen O.P. Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti. Journal of Neuroscience. 16:1996;4457-4467.
21. Nakagawa T., Komune S., Uemura T., Akaike N. Excitatory amino acid response in isolated cells of guinea pig cochlea. Journal of Neurophysiology. 65:1991;715-723.
22. Olney J.W. Excitotoxic amino acids. News Physiological Science. 1:1986;19-23.
23. Partin K.M., Mayer M.L. Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Molecular Pharmacology. 49:1996;142-148.
24. Patneau D.K., Mayer M.L. Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons. Neuron. 6:1991;785-798.
25. Pruss R.M., Akeson R.L., Racke M.M., Wilburn J.L. Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells. Neuron. 7:1991;509-518.
26. Puel J.L. Chemical synaptic transmission in the cochlea. Progress in Neurobiology. 47:1995;449-476.
27. Puel J.L., Pujol R., Ladrech S., Eybalin M. α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) electrophysiological and neurotoxic effects in the guinea pig cochlea. Neuroscience. 45:1991;63-72.
28. Puel J.L., Pujol R., Tribillac F., Ladrech S., Eybalin M. Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity. Journal of Comparative Neurology. 341:1994;241-256.
29. Pujol R., Lenoir M., Robertson D., Eybalin M., Johnstone B.M. Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells. Hearing Research. 18:1985;145-151.
30. Pujol R., Puel J.L., Eybalin M. Implication of non-NMDA and NMDA receptors in cochlear ischemia. NeuroReport. 3:1992;299-302.
31. Robertson D., Johnstone B.M. Effect of divalent cations on spontaneous and evoked activity of single mammalian auditory neurones. Pflügers Archives. 380:1979;7-12.
32. Rothman S.M. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. Journal of Neuroscience. 5:1985;1483-1489.
33. Ruel J., Chen C., Pujol R., Bobbin R.P., Puel J.L. AMPA-preferring glutamate receptors in cochlear physiology of adult guinea pig. Journal of Physiology (London). 518:1999;667-680.
34. 2+ concentration in guinea pig spiral ganglion cells. NeuroReport. 6:1995;421-424.
35. Simmons D.D., Song C., Giboney P. Kainic acid stimulates uptake of divalent cations in postnatal cochlear neurons. NeuroReport. 5:1994;1433-1437.
36. Trussell L.O., Fischback G.D. Glutamate receptor desensitization and its role in synaptic transmission. Neuron. 3:1989;209-218.
37. Zheng X.Y., Henderson D., Hu B.H., McFadden S.L. Recovery of structure and function of inner ear afferent synapses following kainic acid excitotoxicity. Hearing Research. 105:1997;65-76.
38. Zorumski C.F., Thio L L., Clark G.D., Clifford D.B. Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons. Neuron. 5:1990;61-66.