A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6- trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS

Free Radical Biology and Medicine

Volumn 53, Issue 11, 2012, Pages 2028-2042

  Kanno, Takuya ^a   Tanaka, Kazunori ^a   Yanagisawa, Yoshiko ^a   Yasutake, Kaori ^a   Hadano, Shinji ^b   Yoshii, Fumihito ^c   Hirayama, Noriaki ^b   Ikeda, Joh E ^a,d,e  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Amyotrophic lateral sclerosis; Cu Zn superoxide dismutase; Free radicals; Nrf2; Oxidative stress; Transgenic mice; Virtual screening

Indexed keywords

ACETAMIDE DERIVATIVE; ACTIVATING TRANSCRIPTION FACTOR 3; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ENOLASE; GLUCOSE TRANSPORTER 1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIPID PEROXIDE; N [4 (2 PYRIDYL)(1,3 THIAZOL 2 YL)] 2 (2,4,6 TRIMETHYLPHENOXY); PEROXIREDOXIN 1; PROTEIN P21; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ALGORITHM; ANIMAL EXPERIMENT; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; DRUG DETOXIFICATION; DRUG EFFICACY; DRUG SCREENING; FEMALE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ACETAMIDES; ACETYLCYSTEINE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; ENZYME INHIBITORS; FEMALE; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; GLUTAMATE-CYSTEINE LIGASE; HELA CELLS; HEME OXYGENASE-1; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIPID PEROXIDATION; MALE; METABOLIC DETOXICATION, PHASE II; MICE; MICE, TRANSGENIC; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIAZOLES;

MUS MUSCULUS;

EID: 84868560352     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.09.010     Document Type: Article

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