Synthesis and evaluation of novel 18f labeled 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives as ligands for positron emission tomography (PET) imaging of β-amyloid plaques

Journal of Medicinal Chemistry

Volumn 55, Issue 21, 2012, Pages 9283-9296

  Cui, Mengchao ^a   Wang, Xuedan ^a   Yu, Pingrong ^a   Zhang, Jinming ^a,b   Li, Zijing ^a   Zhang, Xiaojun ^b   Yang, Yanping ^a   Ono, Masahiro ^c   Jia, Hongmei ^a   Saji, Hideo ^c   Liu, Boli ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDINYLBENZOTHIAZOLE DERIVATIVE; 2 PYRIDINYLBENZOXAZOLE DERIVATIVE; 5 [5 (2 FLUOROETHOXY)BENZO[D]OXAZOL 2 YL] N METHYLPYRIDIN 2 AMINE F 18; AMYLOID BETA PROTEIN[1-42]; BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; FLUORINE 18; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; REACTION ANALYSIS; STRUCTURE ANALYSIS;

AMYLOID BETA-PEPTIDES; ANIMALS; AUTORADIOGRAPHY; BENZOTHIAZOLES; BENZOXAZOLES; BINDING, COMPETITIVE; BRAIN; DRUG STABILITY; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; MALE; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 84868525365     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300973k     Document Type: Article

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