메뉴 건너뛰기




Volumn 47, Issue 5, 2006, Pages 748-754

Safety, biodistribution, and dosimetry of 123I-IMPY: A novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease

Author keywords

123I IMPY; Alzheimer's disease; Amyloid plaque; Dosimetry; Neurology; SPECT

Indexed keywords

6 IODO 2 (4' DIMETHYLAMINO)PHENYL IMIDAZO[1,2 A]PYRIDINE I 123; DONEPEZIL; PENTETIC ACID; PENTETREOTIDE IN 111; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE; 2,3-DIHYDRO-1H-IMIDAZO(1,2-B)PYRAZOLE; AMYLOID; DIAGNOSTIC AGENT; PYRAZOLE DERIVATIVE; RADIOACTIVE IODINE;

EID: 33745534523     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (143)

References (29)
  • 2
    • 0034701238 scopus 로고    scopus 로고
    • The origins of Alzheimer disease: A is for amyloid
    • Selkoe DJ. The origins of Alzheimer disease: A is for amyloid. JAMA. 2000;283:1615-1617.
    • (2000) JAMA , vol.283 , pp. 1615-1617
    • Selkoe, D.J.1
  • 3
    • 0033869349 scopus 로고    scopus 로고
    • Imaging Alzheimer's amyloid
    • Selkoe DJ. Imaging Alzheimer's amyloid. Nat Biotechnol. 2000;18:823-824.
    • (2000) Nat Biotechnol , vol.18 , pp. 823-824
    • Selkoe, D.J.1
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0038792263 scopus 로고    scopus 로고
    • 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    • 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003;46:2740-2754.
    • (2003) J Med Chem , vol.46 , pp. 2740-2754
    • Mathis, C.A.1    Wang, Y.2    Holt, D.P.3
  • 6
    • 2342446265 scopus 로고    scopus 로고
    • Imaging β-amyloid plaques and neurofibrillary tangles in the aging human brain
    • Mathis CA, Wang Y, Klunk WE. Imaging β-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des. 2004;10:1469-1492.
    • (2004) Curr Pharm Des , vol.10 , pp. 1469-1492
    • Mathis, C.A.1    Wang, Y.2    Klunk, W.E.3
  • 7
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306-319.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 8
    • 0036668810 scopus 로고    scopus 로고
    • Benzofuran derivatives as Aβ-aggregate-specific imaging agents for Alzheimer's disease
    • Ono M, Kung M-P, Hou C, Kung HF. Benzofuran derivatives as Aβ-aggregate-specific imaging agents for Alzheimer's disease. Nucl Med Biol. 2002;29:633-642.
    • (2002) Nucl Med Biol , vol.29 , pp. 633-642
    • Ono, M.1    Kung, M.-P.2    Hou, C.3    Kung, H.F.4
  • 9
    • 3943061873 scopus 로고    scopus 로고
    • Radiosynthesis and evaluation of potential β-amyloid imaging radiotracer for PET [abstract]
    • Wilson A, Nobrega J, Houle S, et al. Radiosynthesis and evaluation of potential β-amyloid imaging radiotracer for PET [abstract]. J Labelled Compds Radiopharm. 2003;46(suppl):S61.
    • (2003) J Labelled Compds Radiopharm , vol.46 , Issue.SUPPL.
    • Wilson, A.1    Nobrega, J.2    Houle, S.3
  • 10
    • 0003045597 scopus 로고    scopus 로고
    • In vivo and in vitro labeling of plaques and tangles in the brain of an Alzheimer's disease patient: A case study [abstract]
    • 65P
    • Agdeppa ED, Kepe V, Shoghi-Jadid K, et al. In vivo and in vitro labeling of plaques and tangles in the brain of an Alzheimer's disease patient: a case study [abstract]. J Nucl Med. 2001;42(suppl):65P.
    • (2001) J Nucl Med , vol.42 , Issue.SUPPL.
    • Agdeppa, E.D.1    Kepe, V.2    Shoghi-Jadid, K.3
  • 11
    • 84903202261 scopus 로고    scopus 로고
    • Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease: Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer disease
    • Shoghi-Jadid K, Small GW, Agdeppa ED, et al. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease: binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer disease. Am J Geriatr Psychiatry. 2002;10:24-35.
    • (2002) Am J Geriatr Psychiatry , vol.10 , pp. 24-35
    • Shoghi-Jadid, K.1    Small, G.W.2    Agdeppa, E.D.3
  • 12
    • 0035821603 scopus 로고    scopus 로고
    • Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates
    • Zhuang Z-P, Kung M-P, Hou C, et al. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem. 2001;44:1905-1914.
    • (2001) J Med Chem , vol.44 , pp. 1905-1914
    • Zhuang, Z.-P.1    Kung, M.-P.2    Hou, C.3
  • 13
    • 0035915387 scopus 로고    scopus 로고
    • Novel stilbenes as probes for amyloid plaques
    • Kung HF, Lee C-W, Zhuang ZP, et al. Novel stilbenes as probes for amyloid plaques. J Am Chem Soc. 2001;123:12740-12741.
    • (2001) J Am Chem Soc , vol.123 , pp. 12740-12741
    • Kung, H.F.1    Lee, C.-W.2    Zhuang, Z.P.3
  • 14
    • 0142011533 scopus 로고    scopus 로고
    • Dimethylamino-fluorenes: Ligands for detecting β amyloid plaques in the brain
    • Lee C-W, Kung M-P, Hou C, Kung HF. Dimethylamino-fluorenes: ligands for detecting β amyloid plaques in the brain. Nucl Med Biol. 2003;30:573-580.
    • (2003) Nucl Med Biol , vol.30 , pp. 573-580
    • Lee, C.-W.1    Kung, M.-P.2    Hou, C.3    Kung, H.F.4
  • 15
    • 3943100779 scopus 로고    scopus 로고
    • Characterization of IMPY as a potential imaging agent for b-amyloid plaques in double transgenic PSAPP mice
    • Kung MP, Hou C, Zhuang ZP, et al. Characterization of IMPY as a potential imaging agent for b-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging. 2004;31:1136-1145.
    • (2004) Eur J Nucl Med Mol Imaging , vol.31 , pp. 1136-1145
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3
  • 16
    • 0037195577 scopus 로고    scopus 로고
    • IMPY: An improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques
    • Kung MP, Hou C, Zhuang ZP, et al. IMPY: an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques. Brain Res. 2002;956:202-210.
    • (2002) Brain Res , vol.956 , pp. 202-210
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3
  • 17
    • 0037448350 scopus 로고    scopus 로고
    • Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain
    • Zhuang ZP, Kung MP, Wilson A, et al. Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain. J Med Chem. 2003;46:237-243.
    • (2003) J Med Chem , vol.46 , pp. 237-243
    • Zhuang, Z.P.1    Kung, M.P.2    Wilson, A.3
  • 18
    • 9244250334 scopus 로고
    • Internal radiation dosimetry
    • 2nd ed. Philadelphia, PA: W.B. Saunders;
    • Sorenson JA, Phelps ME. Internal radiation dosimetry. In: Physics in Nuclear Medicine. 2nd ed. Philadelphia, PA: W.B. Saunders; 1987:197-218.
    • (1987) Physics in Nuclear Medicine , pp. 197-218
    • Sorenson, J.A.1    Phelps, M.E.2
  • 19
    • 2642573583 scopus 로고    scopus 로고
    • Biodistribution and imaging with I-123 ADAM: A serotonin transporter imaging agent
    • Newberg AB, Plössl K, Mozley PD, et al. Biodistribution and imaging with I-123 ADAM: a serotonin transporter imaging agent. J Nucl Med. 2004;45:834-841.
    • (2004) J Nucl Med , vol.45 , pp. 834-841
    • Newberg, A.B.1    Plössl, K.2    Mozley, P.D.3
  • 20
    • 0027396027 scopus 로고
    • The dosimetry of 3-iodo-Schering 23390: Quantification of the radiation burden to healthy humans
    • Mozley PD, Zhu XW, Kung HF, et al. The dosimetry of 3-iodo-Schering 23390: quantification of the radiation burden to healthy humans. J Nucl Med. 1993;34:208-213.
    • (1993) J Nucl Med , vol.34 , pp. 208-213
    • Mozley, P.D.1    Zhu, X.W.2    Kung, H.F.3
  • 21
    • 0027374040 scopus 로고
    • Biodistribution and dosimetry of I-123 IBF: A potent radioligand for imaging the D2 dopamine receptor
    • Mozley PD, Stubbs JS, Kung HF, et al. Biodistribution and dosimetry of I-123 IBF: a potent radioligand for imaging the D2 dopamine receptor. J Nucl Med. 1993;34:1910-1917.
    • (1993) J Nucl Med , vol.34 , pp. 1910-1917
    • Mozley, P.D.1    Stubbs, J.S.2    Kung, H.F.3
  • 22
    • 0029067357 scopus 로고
    • Dosimetry of a D2/D3 dopamine receptor antagonist that can be used with PET or SPECT
    • Mozley PD, Stubbs JB, Kim H-J, et al. Dosimetry of a D2/D3 dopamine receptor antagonist that can be used with PET or SPECT. J Nucl Med. 1995;36:1322-1331.
    • (1995) J Nucl Med , vol.36 , pp. 1322-1331
    • Mozley, P.D.1    Stubbs, J.B.2    Kim, H.-J.3
  • 23
    • 0029989617 scopus 로고    scopus 로고
    • Dosimetry of an iodine-123-labeled tropane to image dopamine transporters
    • Mozley PD, Stubbs JB, Kim H-J, et al. Dosimetry of an iodine-123-labeled tropane to image dopamine transporters. J Nucl Med. 1996;37:151-159.
    • (1996) J Nucl Med , vol.37 , pp. 151-159
    • Mozley, P.D.1    Stubbs, J.B.2    Kim, H.-J.3
  • 24
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer' Disease
    • McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer' Disease. Neurology. 1984;34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 25
    • 0015897292 scopus 로고
    • Dose to the fetus from radionuclides in the bladder
    • Cloutier RJ, Smith SA, Watson EE, et al. Dose to the fetus from radionuclides in the bladder. Health Phys. 1973;25:147-161.
    • (1973) Health Phys , vol.25 , pp. 147-161
    • Cloutier, R.J.1    Smith, S.A.2    Watson, E.E.3
  • 28
    • 6844249433 scopus 로고    scopus 로고
    • 123IFP-CIT: A potent radioligand for imaging the dopamine transporters
    • 123IFP-CIT: a potent radioligand for imaging the dopamine transporters. Eur J Nucl Med. 1998;25:24-30.
    • (1998) Eur J Nucl Med , vol.25 , pp. 24-30
    • Booij, J.1    Busemann, S.E.2    Stabin, M.G.3
  • 29
    • 0027368147 scopus 로고
    • Dosimetry of iodine-123 iobenzamide in healthy volunteers
    • Verhoeff NP, Sokole EB, Stabin M, et al. Dosimetry of iodine-123 iobenzamide in healthy volunteers. Eur J Nucl Med. 1993;20:747-752.
    • (1993) Eur J Nucl Med , vol.20 , pp. 747-752
    • Verhoeff, N.P.1    Sokole, E.B.2    Stabin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.