Molecular genetics of preeclampsia and HELLP syndrome - A review

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 12, 2012, Pages 1960-1969

  Jebbink, Jiska ^a   Wolters, Astrid ^a   Fernando, Febilla ^a,b   Afink, Gijs ^a   van der Post, Joris ^a   Ris Stalpers, Carrie ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Gene; HELLP syndrome; IUGR; Preeclampsia; Pregnancy

Indexed keywords

ENDOGLIN; VASCULOTROPIN RECEPTOR 1;

ALLELE; ANGIOGENESIS; CONFINED PLACENTAL MOSAICISM; CYTOTROPHOBLAST; GENE EXPRESSION; HELLP SYNDROME; HUMAN; INFLAMMATION; INHERITANCE; INTRAUTERINE GROWTH RETARDATION; LINKAGE ANALYSIS; LIVER FATTY DEGENERATION; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; MOSAICISM; NONHUMAN; OXIDATIVE STRESS; PREECLAMPSIA; PRIORITY JOURNAL; REPRODUCTION; REVIEW; TRISOMY; UNIPARENTAL DISOMY;

FEMALE; HELLP SYNDROME; HUMANS; MOSAICISM; PRE-ECLAMPSIA; PREGNANCY;

EID: 84868452616     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.08.004     Document Type: Review

References (105)

1. GOPEC Consortium Disentangeling fetal and maternal susceptibility for pre-eclampsia: a British multicentercandidate-gene study. Am. J. Hum. Genet. 2005, 77:127-131.
2. Ahn K.S., Aggarwal B.B. Transcription factor NF-kappaB: a sensor for smoke and stress signals. Ann. N. Y. Acad. Sci. 2005, 1056:218-233.
3. Amiel A., Bouaron N., Kidron D., Sharony R., Gaber E., Fejgin M.D. CGH in the detection of confined placental mosaicism (CPM) in placentas of abnormal pregnancies. Prenat. Diagn. 2002, 22:752-758.
4. Arngrímsson R., Björnsson S., Geirsson R.T., Björnsson H., Walker J.J., Snaedal G. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br. J. Obstet. Gynaecol. 1990, 97:762-769.
5. Arngrímsson R., Sigurõardóttir S., Frigge M.L., Bjarnadóttir R.I., Jóhnson T., Stefánsson H., Baldursdóttir A., Einarsdóttir A.S., Palsson B., Snorradóttir S., Lachmeijer A.M., Nicolae D., Kong A., Bragason B.T., Gulcher J.R., Geirsson R.T., Stefánsson K. A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum. Mol. Genet. 1999, 8:1799-1805.
6. Baksu A., Taskin M., Goker N., Baksu B., Uluocak A. Plasma homocysteine in late pregnancies complicated with preeclampsia and in newborns. Am. J. Perinatol. 2006, 23:31-35.
7. Bdolah Y., Palomaki G.E., Yaron Y., Bdolah-Abram T., Goldman M., Levine R.J., Sachs B.P., Haddow J.E., Karumanchi S.A. Circulating angiogenic proteins in trisomy 13. Am. J. Obstet. Gynecol. 2006, 194:239-245.
8. Berends A.L., Bertoli-Avella A.M., de Groot C.J., van Duijn C.M., Oostra B.A., Steegers E.A. STOX1 gene in pre-eclampsia and intrauterine growth restriction. BJOG. 2007, 114:1163-1167.
9. Boyd P.A., Lindenbaum R.H., Redman C. Pre-eclampsia and trisomy 13: a possible association. Lancet 1987, 2:425-427.
10. Brandenburg H., Los F.J. P. in 't Veld, Clinical significance of placenta-confined nonmosaic trisomy 16. Am. J. Obstet. Gynecol. 1996, 174:1663-1664.
11. Brosens I.A., Robertson W.B., Dixon H.G. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet. Gynecol. Annu. 1972, 1:177-191.
12. Castrillon D.H., Sun D., Weremowicz S., Fisher R.A., Crum C.P., Genest D.R. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am. J. Surg. Pathol. 2001, 25:1225-1230.
13. Caughey A.B., Stotland N.E., Washington A.E., Escobar G.J. Maternal ethnicity, paternal ethnicity, and parental ethnic discordance: predictors of preeclampsia. Obstet. Gynecol. 2005, 106:156-161.
14. Chappell L.C., Seed P.T., Briley A.L., Kelly F.J., Lee R., Hunt B.J., Parmar K., Bewley S.J., Shennan A.H., Steer P.J., Poston L. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999, 354:810-816.
15. Chappell S., Morgan L. Searching for genetic clues to the causes of pre-eclampsia. Clin. Sci. (Lond.) 2006, 110:443-458.
16. Chen Q., Stone P., Ching L.M., Chamley L. A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J. Pathol. 2009, 217:122-130.
17. Chesley L.C., Cooper D.W. Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br. J. Obstet. Gynaecol. 1986, 93:898-908.
18. Cindrova-Davies T. Gabor Than Award Lecture 2008: pre-eclampsia - from placental oxidative stress to maternal endothelial dysfunction. Placenta 2009, 30(Suppl. A).
19. Cnattingius S., Reilly M., Pawitan Y., Lichtenstein P. Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. Am. J. Med. Genet. A 2004, 130A:365-371.
20. Conde-Agudelo A., Romero R., Kusanovic J.P., Hassan S.S. Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis. Am. J. Obstet. Gynecol. 2011, 204:503-512.
21. Cooper D.W., Liston W.A. Genetic control of severe pre-eclampsia. J. Med. Genet. 1979, 16:409-416.
22. Dekker G., Robillard P.Y., Roberts C. The etiology of preeclampsia: the role of the father. J. Reprod. Immunol. 2011, 89:126-132.
23. Delles C., McBride M.W., Graham D., Padmanabhan S., Dominiczak A.F. Genetics of hypertension: from experimental animals to humans. Biochim. Biophys. Acta 2010, 1802:1299-1308.
24. den Boer M.E., Ijlst L., Wijburg F.A., Oostheim W., van Werkhoven M.A., van Pampus M.G., Heymans H.S., Wanders R.J. Heterozygosity for the common LCHAD mutation (1528g>C) is not a major cause of HELLP syndrome and the prevalence of the mutation in the Dutch population is low. Pediatr. Res. 2000, 48:151-154.
25. Duckitt K., Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 2005, 330:565.
26. Falcao S., Bisotto S., Gutkowska J., Lavoie J.L. Hyperhomocysteinemia is not sufficient to cause preeclampsia in an animal model: the importance of folate intake. Am. J. Obstet. Gynecol. 2009, 200. 198.e.1-5.
27. Falcao S., Stoyanova E., Cloutier G., Maurice R.L., Gutkowska J., Lavoie J.L. Mice overexpressing both human angiotensinogen and human renin as a model of superimposed preeclampsia on chronic hypertension. Hypertension 2009, 54:1401-1407.
28. Founds S.A., Conley Y.P., Lyons-Weiler J.F., Jeyabalan A., Hogge W.A., Conrad K.P. Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta 2009, 30:15-24.
29. Founds S.A., Terhorst L.A., Conrad K.P., Hogge W.A., Jeyabalan A., Conley Y.P. Gene expression in first trimester preeclampsia placenta. Biol. Res. Nurs. 2011, 13:134-139.
30. Ganzevoort W., Rep A., Bonsel G.J., de Vries J.I., Wolf H. Dynamics and incidence patterns of maternal complications in early-onset hypertension of pregnancy. BJOG. 2007, 114:741-750.
31. Gerber H.P., Condorelli F., Park J., Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 1997, 272:23659-23667.
32. Girardi G., Prohászka Z., Bulla R., Tedesco F., Scherjon S. Complement activation in animal and human pregnancies as a model for immunological recognition. Mol. Immunol. 2011, 48:1621-1630.
33. Heydanus R., Defoort P., Dhont M. Pre-eclampsia and trisomy 13. Eur. J. Obstet. Gynecol. Reprod. Biol. 1995, 60:201-202.
34. Hiby S.E., Walker J.J., O'shaughnessy K.M., Redman C.W., Carrington M., Trowsdale J., Moffett A. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J. Exp. Med. 2004, 200:957-965.
35. Hill L.D., York T.P., Kusanovic J.P., Gomez R., Eaves L.J., Romero R., Strauss J.F. Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. PLoS One 2011, 6:e16681.
36. Ibdah J.A., Bennett M.J., Rinaldo P., Zhao Y., Gibson B., Sims H.F., Strauss A.W. A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N. Engl. J. Med. 1999, 340:1723-1731.
37. Iglesias-Platas I., Monk D., Jebbink J., Buimer M., Boer K., van der Hills F., Apostolidou S., Ris-Stalpers C., Stanier P., Moore G.E. STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nat. Genet. 2007, 39:279-280.
38. James J.L., Whitley G.S., Cartwright J.E. Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces. J. Pathol. 2010, 221:363-378.
39. Jebbink J., Keijser R., Veenboer G., van der Post J., Ris-Stalpers C., Afink G. Expression of placental FLT1 transcript variants relates to both gestational hypertensive disease and fetal growth. Hypertension 2011, 58:70-76.
40. Kaitu'u-Lino T.J., Palmer K.R., Whitehead C.L., Williams E., Lappas M., Tong S. MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin. Am. J. Pathol. 2012, 180:888-894.
41. Kalousek D.K. Pathogenesis of chromosomal mosaicism and its effect on early human development. Am. J. Med. Genet. 2000, 91:39-45.
42. Kalousek D.K., Langlois S., Barrett I., Yam I., Wilson D.R., Howard-Peebles P.N., Johnson M.P., Giorgiutti E. Uniparental disomy for chromosome 16 in humans. Am. J. Hum. Genet. 1993, 52:8-16.
43. Kanasaki K., Palmsten K., Sugimoto H., Ahmad S., Hamano Y., Xie L., Parry S., Augustin H.G., Gattone V.H., Folkman J., Strauss J.F., Kalluri R. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 2008, 453:1117-1121.
44. Kanayama N., Takahashi K., Matsuura T., Sugimura M., Kobayashi T., Moniwa N., Tomita M., Nakayama K. Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice. Mol. Hum. Reprod. 2002, 8:1129-1135.
45. Kassab S.E., Abu-Hijleh M.F., Al-Shaikh H.B., Nagalla D.S. Hyperhomocysteinemia in pregnant rats: effects on arterial pressure, kidneys and fetal growth. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005, 122:177-181.
46. Kendall R.L., Thomas K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:10705-10709.
47. Kho E.M., McCowan L.M., North R.A., Roberts C.T., Chan E., Black M.A., Taylor R.S., Dekker G.A. Duration of sexual relationship and its effect on preeclampsia and small for gestational age perinatal outcome. J. Reprod. Immunol. 2009, 82:66-73.
48. Kilpatrick D.C., Liston W.A., Gibson F., Livingstone J. Association between susceptibility to pre-eclampsia within families and HLA DR4. Lancet 1989, 2:1063-1065.
49. Kivinen K., Peterson H., Hiltunen L., Laivuori H., Heino S., Tiala I., Knuutila S., Rasi V., Kere J. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007, 15:494-497.
50. Koster M.P., Stoutenbeek P., Visser G.H., Schielen P.C. Trisomy 18 and 13 screening: consequences for the Dutch Down syndrome screening programme. Prenat. Diagn. 2010, 30:287-289.
51. Kruglyak L., Daly M.J., Reeve-Daly M.P., Lander E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 1996, 58:1347-1363.
52. Kumasawa K., Ikawa M., Kidoya H., Hasuwa H., Saito-Fujita T., Morioka Y., Takakura N., Kimura T., Okabe M. Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:1451-1455.
53. Lachmeijer A.M., Arngrímsson R., Bastiaans E.J., Frigge M.L., Pals G., Sigurõardóttir S., Stefánsson H., Pálsson B., Nicolae D., Kong A., Aarnoudse J.G., Gulcher J.R., Dekker G.A., ten Kate L.P., Stefánsson K. A genome-wide scan for preeclampsia in the Netherlands. Eur. J. Hum. Genet. 2001, 9:758-764.
54. Larroque B., Bréart G., Kaminski M., Dehan M., André M., Burguet A., Grandjean H., Ledésert B., Lévêque C., Maillard F., Matis J., Rozé J.C., Truffert P. Survival of very preterm infants: Epipage, a population based cohort study. Arch. Dis. Child. Fetal Neonatal Ed. 2004, 89:F139-F144.
55. Lee M.H., Reynisdottir I., Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995, 9:639-649.
56. Levine R.J., Lam C., Qian C., Yu K.F., Maynard S.E., Sachs B.P., Sibai B.M., Epstein F.H., Romero R., Thadhani R., Karumanchi S.A. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med. 2006, 355:992-1005.
57. Lim J.H., Kim S.Y., Kim d.J., Park S.Y., Han H.W., Han J.Y., Lee S.W., Yang J.H., Ryu H.M. Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17alpha in preeclampsia. Pharmacogenet. Genomics 2010, 20:605-610.
58. Liston W.A., Kilpatrick D.C. Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus?. Br. J. Obstet. Gynaecol. 1991, 98:1079-1086.
59. Maruotti G., Del B.A., Amato A.N., Lombardi L., Fulgeri A.M., Pietropaolo F. Preeclampsia and high serum levels of homocysteine. Minerva Ginecol. 2005, 57:165-170.
60. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., Libermann T.A., Morgan J.P., Sellke F.W., Stillman I.E., Epstein F.H., Sukhatme V.P., Karumanchi S.A. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2003, 111:649-658.
61. Moffett A., Hiby S.E. How Does the maternal immune system contribute to the development of pre-eclampsia?. Placenta 2007, 28(Suppl. A):S51-S56.
62. Moffett A., Loke C. Immunology of placentation in eutherian mammals. Nat. Rev. Immunol. 2006, 6:584-594.
63. Moster D., Lie R.T., Markestad T. Long-term medical and social consequences of preterm birth. N. Engl. J. Med. 2008, 359:262-273.
64. Pecks U., Maass N., Neulen J. Oocyte donation: a risk factor for pregnancy-induced hypertension: a meta-analysis and case series. Dtsch. Arztebl. Int. 2011, 108:23-31.
65. Pijnenborg R., Anthony J., Davey D.A., Rees A., Tiltman A., Vercruysse L., van Assche A. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br. J. Obstet. Gynaecol. 1991, 98:648-655.
66. Rath W. Pre-eclampsia and inherited thrombophilia: a reappraisal. Semin. Thromb. Hemost. 2011, 37:118-124.
67. Redman C.W. Preeclampsia: a multi-stress disorder. Rev. Med. Interne 2011, 32(Suppl. 1):S41-S44.
68. Redman C.W., Sargent I.L. Latest advances in understanding preeclampsia. Science 2005, 308:1592-1594.
69. Redman C.W., Sargent I.L. Immunology of pre-eclampsia. Am. J. Reprod. Immunol. 2010, 63:534-543.
70. Reister F., Frank H.G., Kingdom J.C., Heyl W., Kaufmann P., Rath W., Huppertz B. Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women. Lab. Invest. 2001, 81:1143-1152.
71. Roberts J.M., Pearson G., Cutler J., Lindheimer M. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension 2003, 41:437-445.
72. Robillard P.Y., Dekker G., Chaouat G., Hulsey T.C., Saftlas A. Epidemiological studies on primipaternity and immunology in preeclampsia-a statement after twelve years of workshops. J. Reprod. Immunol. 2011, 89:104-117.
73. Robillard P.Y., Hulsey T.C. Association of pregnancy-induced-hypertension, pre-eclampsia, and eclampsia with duration of sexual cohabitation before conception. Lancet 1996, 347:619.
74. Robinson W.P., Peñaherrera M.S., Jiang R., Avila L., Sloan J., McFadden D.E., Langlois S., von Dadelszen P. Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction. Prenat. Diagn. 2010, 30:1-8.
75. Romanelli V., Belinchón A., Campos-Barros A., Heath K.E., García-Miñaur S., Martínez-Glez V., Palomo R., Mercado G., Gracia R., Lapunzina P. CDKN1C mutations in HELLP/preeclamptic mothers of Beckwith-Wiedemann Syndrome (BWS) patients. Placenta 2009, 30:551-554.
76. Roy H., Bhardwaj S., Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett. 2006, 580:2879-2887.
77. Saigal S., Doyle L.W. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008, 371:261-269.
78. Salonen R.H., Lichtenstein P., Lipworth L., Cnattingius S. Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am. J. Med. Genet. 2000, 91:256-260.
79. Sasaki T., Nishihara H., Hirakawa M., Fujimura K., Tanaka M., Kokubo N., Kimura-Yoshida C., Matsuo I., Sumiyama K., Saitou N., Shimogori T., Okada N. Possible involvement of SINEs in mammalian-specific brain formation. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:4220-4225.
80. Sela S., Itin A., Natanson-Yaron S., Greenfield C., Goldman-Wohl D., Yagel S., Keshet E. A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia. Circ. Res. 2008, 102:1566-1574.
81. Serrano N.C., Casas J.P., Díaz L.A., Páez C., Mesa C.M., Cifuentes R., Monterrosa A., Bautista A., Hawe E., Hingorani A.D., Vallance P., López-Jaramillo P. Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. Hypertension 2004, 44:702-707.
82. Shenoy V., Kanasaki K., Kalluri R. Pre-eclampsia: connecting angiogenic and metabolic pathways. Trends Endocrinol. Metab. 2010, 21:529-536.
83. Silasi M., Cohen B., Karumanchi S.A., Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet. Gynecol. Clin. North Am. 2010, 37:239-253.
84. Silva L.M., Coolman M., Steegers E.A., Jaddoe V.W., Moll H.A., Hofman A., Mackenbach J.P., Raat H. Low socioeconomic status is a risk factor for preeclampsia: the Generation R Study. J. Hypertens. 2008, 26:1200-1208.
85. Skjaerven R., Vatten L.J., Wilcox A.J., Rønning T., Irgens L.M., Lie R.T. Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ 2005, 331:877.
86. Steegers E.A., von Dadelszen P., Duvekot J.J., Pijnenborg R. Pre-eclampsia. Lancet 2010, 376:631-644.
87. Tammela T., Enholm B., Alitalo K., Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 2005, 65:550-563.
88. Thomas C.P., Andrews J.I., Raikwar N.S., Kelley E.A., Herse F., Dechend R., Golos T.G., Liu K.Z. A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia. J. Clin. Endocrinol. Metab. 2009, 94:2524-2530.
89. Thomas P.D., Kejariwal A., Campbell M.J., Mi H., Diemer K., Guo N., Ladunga I., Ulitsky-Lazareva B., Muruganujan A., Rabkin S., Vandergriff J.A., Doremieux O. PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res. 2003, 31:334-341.
90. Toutain J., Labeau-Gaüzere C., Barnetche T., Horovitz J., Saura R. Confined placental mosaicism and pregnancy outcome: a distinction needs to be made between types 2 and 3. Prenat. Diagn. 2010, 30:1155-1164.
91. Treloar S.A., Cooper D.W., Brennecke S.P., Grehan M.M., Martin N.G. An Australian twin study of the genetic basis of preeclampsia and eclampsia. Am. J. Obstet. Gynecol. 2001, 184:374-381.
92. Tuohy J.F., James D.K. Pre-eclampsia and trisomy 13. Br. J. Obstet. Gynaecol. 1992, 99:891-894.
93. van der Hoorn M.L., Lashley E.E., Bianchi D.W., Claas F.H., Schonkeren C.M., Scherjon S.A. Clinical and immunologic aspects of egg donation pregnancies: a systematic review. Hum. Reprod. Update 2010, 16:704-712.
94. van der Post J.A., Lok C.A., Boer K., Sturk A., Sargent I.L., Nieuwland R. The functions of microparticles in pre-eclampsia. Semin. Thromb. Hemost. 2011, 37:146-152.
95. van Dijk M., Mulders J., Poutsma A., Konst A.A., Lachmeijer A.M., Dekker G.A., Blankenstein M.A., Oudejans C.B. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005, 37:514-519.
96. Venkatesha S., Toporsian M., Lam C., Hanai J., Mammoto T., Kim Y.M., Bdolah Y., Lim K.H., Yuan H.T., Libermann T.A., Stillman I.E., Roberts D., D'Amore P.A., Epstein F.H., Sellke F.W., Romero R., Sukhatme V.P., Letarte M., Karumanchi S.A. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat. Med. 2006, 12:642-649.
97. Vollebregt K.C., Wolf H., Boer K., van der Wal M.F., Vrijkotte T.G., Bonsel G.J. Does physical activity in leisure time early in pregnancy reduce the incidence of preeclampsia or gestational hypertension?. Acta Obstet. Gynecol. Scand. 2010, 89:261-267.
98. Wang K., Zhou Q., He Q., Tong G., Zhao Z., Duan T. The possible role of AhR in the protective effects of cigarette smoke on preeclampsia. Med. Hypotheses 2011, 77:872-874.
99. Wilcken B., Leung K.C., Hammond J., Kamath R., Leonard J.V. Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency. Lancet 1993, 341:407-408.
100. Wright A., Zhou Y., Weier J.F., Caceres E., Kapidzic M., Tabata T., Kahn M., Nash C., Fisher S.J. Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am. J. Med. Genet. A 2004, 130A:354-364.
101. Xie C., Yao M.Z., Liu J.B., Xiong L.K. A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia. Cytokine 2011, 56(3):550-559.
102. Xu H., Perez-Cuevas R., Xiong X., Reyes H., Roy C., Julien P., Smith G., von Dadelszen P., Leduc L., Audibert F., Moutquin J.M., Piedboeuf B., Shatenstein B., Parra-Cabrera S., Choquette P., Winsor S., Wood S., Benjamin A., Walker M., Helewa M., Dube J., Tawagi G., Seaward G., Ohlsson A., Magee L.A., Olatunbosun F., Gratton R., Shear R., Demianczuk N., Collet J.P., Wei S., Fraser W.D. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am. J. Obstet. Gynecol. 2010, 202:239.
103. Yong P.J., Langlois S., von Dadelszen P., Robinson W. The association between preeclampsia and placental trisomy 16 mosaicism. Prenat. Diagn. 2006, 26:956-961.
104. Zhou Y., McMaster M., Woo K., Janatpour M., Perry J., Karpanen T., Alitalo K., Damsky C., Fisher S.J. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am. J. Pathol. 2002, 160:1405-1423.
105. Zusterzeel P.L., Peters W.H., Burton G.J., Visser W., Roelofs H.M., Steegers E.A. Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. Gynecol. Obstet. Invest. 2007, 63:209-213.