Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1451-1455

  Kumasawa, Keiichi ^a,b   Ikawa, Masahito ^a   Kidoya, Hiroyasu ^c   Hasuwa, Hidetoshi ^a   Saito Fujita, Tomoko ^a,d   Morioka, Yuka ^a,e   Takakura, Nobuyuki ^c   Kimura, Tadashi ^b   Okabe, Masaru ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

3 hydroxy 3 methyl glutaryl CoA; Hemolytic anemia, elevated liver enzymes, and low platelet count; Trophoblast

Indexed keywords

ALBUMIN; ATORVASTATIN; CREATININE; LENTIVIRUS VECTOR; PLACENTAL GROWTH FACTOR; PRAVASTATIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; FETUS; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; HYPERTENSION; INTRAUTERINE GROWTH RETARDATION; LOW DRUG DOSE; NONHUMAN; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEINURIA;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; HEK293 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, INTRAPERITONEAL; LENTIVIRUS; MALE; MICE; MICE, TRANSGENIC; PLACENTA; PRAVASTATIN; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY PROTEINS; TRANSDUCTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

MURINAE; MUS;

EID: 79952145885     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011293108     Document Type: Article

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