Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes

Gynecologic and Obstetric Investigation

Volumn 63, Issue 4, 2007, Pages 209-213

  Zusterzeel, Petra L M ^a   Peters, Wilbert H M ^a   Burton, Graham J ^b   Visser, Willy ^c   Roelofs, Hennie M J ^a   Steegers, Eric A P ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Biotransformation enzymes; Genetic polymorphisms; Pre eclampsia

Indexed keywords

CYTOCHROME P450 1A1; ENZYME; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1;

ADULT; ARTICLE; BIOTRANSFORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DETOXIFICATION; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HELLP SYNDROME; HUMAN; MAJOR CLINICAL STUDY; PREECLAMPSIA; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL ANALYSIS;

ADULT; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A1; ENZYMES; EPOXIDE HYDROLASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE TRANSFERASE; HUMANS; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY;

EID: 34248365116     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000097987     Document Type: Article

References (22)

1. Merviel P, Carbillon L, Challier JC, Rabreau M, Beaufils M, Uzan S: Pathophysiology of preeclampsia: links with implantation disorders. Eur J Obstet Gynecol Repr Biol 2004;115:134-147.
2. Roberts JM, Cooper DW: Pathogenesis and genetics of preeclampsia. Lancet 2001;357:53-56.
3. Thornton JG, Onwude JL: Preeclampsia: discordance among identical twins. Br Med J 1991;303:1241-1242.
4. Rodgers GM, Taylor RN, Roberts JM: Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am J Obstet Gynecol 1988;159:908-914.
5. Tsukimori K, Maeda H, Shingu M, Koyanagi T, Nobunaga M, Nakano H: The possible role of endothelial cells in hypertensive disorders during pregnancy. Obstet Gynecol 1992;80:229-233.
6. Parkinson A: Biotransformation of xenobiotics; in Klaassen CD (ed): Toxicology: The Basic Science of Poisons, ed 5. New York, McGraw-Hill, 1996, pp 113-185.
7. Zusterzeel PLM, Visser W, Peters WHM, Merkus HMWM, Nelen WLDM, Steegers EAP: Polymorphisms in the glutathione Stransferase P1 gene and risk for preeclampsia. Obstet Gynecol 2000;95:50-54.
8. Zusterzeel PLM, Peters WHM, Visser W, Hermsen KJM, Roelofs HMJ, Steegers EAP: A polymorphism in the gene of microsomal epoxide hydrolase and the risk for preeclampsia. J Med Genet 2001;38:234-237.
9. Brockmoller J, Kerb R, Drakoulis N, Nitz M, Roots I: Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controls. Cancer Res 1993;53:1004-1011.
10. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB: Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 1994;300:271-276.
11. Shields PG, Bowman ED, Harrington AM, Doan VT, Weston A: Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes. Cancer Res 1993;53:3486-3492.
12. Harries LW, Stubbins MJ, Forman D, Howard GC, Wolf CR: Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 1997;18:641-644.
13. Redman CWG, Sargent IL: Placental debris, oxidative stress and pre-eclampsia. Placenta 2000;21:597-602.
14. Walsh SW, Vaughan JE, Wang Y, Roberts LJ: Placental isoprostane is significantly increased in preeclampsia. FASEB J 2000;14:1289-1296.
15. Zusterzeel PLM, Rutten H, Roelofs HMJ, Peters WHM, Steegers EAP: Protein carbonyls in decidua and placenta of pre-eclamptic women as markers of oxidative stress. Placenta 2001;22:213-219.
16. Wang Y, Walsh SW: Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in preeclampsia. Placenta 2001;22:206-212.
17. Sikkema JM, van Rijn BB, Franx A, Bruinse HW, de Roos R, Stroes ESG, van Faassen EE: Placental superoxide is increased in pre-eclampsia. Placenta 2001;22:304-308.
18. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, Van Assche FA: A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynaecol 1994;101:669-674.
19. Jauniaux E, Watson AL, Hempstock J, Bao Y-P, Skepper JN, Burton GJ: Onset of maternal arterial blood flow and placental oxidative stress; a possible factor in human early pregnancy failure. Am J Pathol 2000;157:2111-2122.
20. Hung TH, Skepper JN, Burton GJ: In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol 2001;159:1031-1043.
21. Martin CB, McGaughey HS, Kaiser IH, Donner MW, Ramsey EM: Intermittent functioning of the uteroplacental arteries. Am J Obstet Gynecol 1964;90:819-823.
22. Hafner E, Metzenbauer M, Hofinger D, Munkel M, Gassner R, Schuchter K, Dillinger-Paller B, Philipp K: Placental growth from the first to the second trimester of pregnancy in SGA-foetuses and pre-eclamptic pregnancies compared to normal foetuses. Placenta 2003;24:336-342.